Irit Adini, PhD
Center for Engineering in Medicine & Surgery
51 Blossom St.
Boston,
MA
02114
Phone: 617-726-3474
Fax: 617-573-9471
Email: iadini@mgh.harvard.edu
About Dr. Adini
Brief Biography
Irit Adini, Ph., received her MSc in Biochemistry and PhD in Microbiology and Molecular Genetics from the Hebrew University, Jerusalem, Israel, with specialization in immunogenetics of parasite and drug discovery. She joined Beth Israel Deaconess Medical Center as a postdoctoral fellow, and later became and Instructor at Harvard Medical School and Children’s Hospital Boston. Dr. Adini joined the Center of Engineering in Medicine & Surgery at Massachusetts General Hospital in 2017 and was promoted to Assistant Professor in Surgery at Harvard Medical School in 2018. As an instructor at Boston Children’s Hospital, she studied the effects of pigmentation on ocular angiogenesis. This work led to the investigation of a novel pigment-dependent angiogenesis mechanism, in which melanocytes secrete the proangiogenic factor fibromodulin (FMOD), which negatively regulated by melanin levels. This work demonstrates a fundamental role for melanocytes in regulating the local angiogenic balance and an inflammatory factor in tissues such as the eye and skin.
Research Summary
Dr. Adini’s research focuses on the role of the melanocytic microenvironment in tissue neovascularization-dependent disorders and inflammatory skin disorders, such as Age-Related Macular Degeneration (ARMD), Cancer and Connective Tissue Diseases. The Adini lab integrates the multidisciplinary fields of cell and molecular biology, immunometabolism, vascular biology, and tissue engineering. Specifically, her group aims to uncover molecular basis of differences in the incidence of angiogenesis-dependent diseases among individuals of different skin colors. More specifically, her research concentrates on understanding melanocyte-mediated micro-environment via fibromodulin (FMOD) interaction during neovascularization and immunometabolism.
Education
- MSc, Biochemistry, Hebrew University, Jerusalem, Israel
- PhD, Microbiology and Molecular Genetics, Hebrew University, Jerusalem, Israel
Research Thrusts
Publications
Center for Engineering in Medicine & Surgery
A place where scientific rigor and creativity are matched by a sense of community, the Center for Engineering in Medicine & Surgery is a relatively young and vibrant enterprise that draws strength from its diversity and collective spirit, and from its affiliations with surrounding biomedical research institutions, including Massachusetts General Hospital, the Shriners Hospitals for Children and the Massachusetts Institute of Technology.