Publications from the Center for Engineering in Medicine & Surgery
A listing of recent publications from the investigators at the Center for Engineering in Medicine & Surgery at Massachusetts General Hospital.
Vidula N, Dubash T, Lawrence MS, Simoneau A, Niemierko A, Blouch E, Nagy B, Roh W, Chirn B, Reeves BA, Malvarosa G, Lennerz J, Isakoff SJ, Juric D, Micalizzi D, Wander S, Spring L, Moy B, Shannon K, Younger J, Lanman R, Toner M, Iafrate AJ, Getz G, Zou L, Ellisen LW, Maheswaran S, Haber DA, Bardia A. Identification of Somatically Acquired BRCA1/2 Mutations by cfDNA Analysis in Patients with Metastatic Breast Cancer. Clin Cancer Res. 2020;26(18):4852-62. Epub 2020/06/24. doi: 10.1158/1078-0432.Ccr-20-0638. PubMed PMID: 32571788; PMCID: PMC7501190.
Mert S, Bulutoglu B, Chu C, Dylewski M, Lin FM, Yu YM, Yarmush ML, Sheridan RL, Uygun K. Multi-organ metabolomics and lipidomics provide new insights into fat infiltration in the liver, muscle wasting and liver-muscle crosstalk following burn injury. J Burn Care Res. 2020. Epub 2020/09/03. doi: 10.1093/jbcr/iraa145. PubMed PMID: 32877506.
Drain PK, Bardon AR, Simoni JM, Cressey TR, Anderson P, Sevenler D, Olanrewaju AO, Gandhi M, Celum C. Point-of-care and Near Real-time Testing for Antiretroviral Adherence Monitoring to HIV Treatment and Prevention. Curr HIV/AIDS Rep. 2020;17(5):487-98. Epub 2020/07/07. doi: 10.1007/s11904-020-00512-3. PubMed PMID: 32627120; PMCID: PMC7492442.
Bashyam A, Frangieh CJ, Raigani S, Sogo J, Bronson RT, Uygun K, Yeh H, Ausiello DA, Cima MJ. A portable single-sided magnetic-resonance sensor for the grading of liver steatosis and fibrosis. Nat Biomed Eng. 2020. Epub 2020/12/02. doi: 10.1038/s41551-020-00638-0. PubMed PMID: 33257853.
Hong X, Roh W, Sullivan RJ, Wong KHK, Wittner BS, Guo H, Dubash TD, Sade-Feldman M, Wesley B, Horwitz E, Boland GM, Marvin DL, Bonesteel T, Lu C, Aguet F, Burr R, Freeman SS, Parida L, Calhoun K, Jewett MK, Nieman LT, Hacohen N, Näär AM, Ting DT, Toner M, Stott SL, Getz G, Maheswaran S, Haber DA. The lipogenic regulator SREBF2 induces Transferrin in circulating melanoma cells and suppresses ferroptosis. Cancer Discov. 2020. Epub 2020/11/19. doi: 10.1158/2159-8290.Cd-19-1500. PubMed PMID: 33203734.
Clark IC, Delley CL, Sun C, Thakur R, Stott SL, Thaploo S, Li Z, Quintana FJ, Abate AR. Targeted Single-Cell RNA and DNA Sequencing With Fluorescence-Activated Droplet Merger. Anal Chem. 2020;92(21):14616-23. Epub 2020/10/14. doi: 10.1021/acs.analchem.0c03059. PubMed PMID: 33049138.
Raigani S, De Vries RJ, Carroll C, Chen YW, Chang DC, Shroff SG, Uygun K, Yeh H. Viability testing of discarded livers with normothermic machine perfusion: Alleviating the organ shortage outweighs the cost. Clin Transplant. 2020;34(11):e14069. Epub 2020/08/30. doi: 10.1111/ctr.14069. PubMed PMID: 32860634.
Spencer RKW, Saeidi N, Ha BY. Nematic ordering of worm-like polymers near an interface. J Chem Phys. 2020;152(20):204907. Epub 2020/06/04. doi: 10.1063/1.5132928. PubMed PMID: 32486695; PMCID: PMC7261236.
Luther J, Khan S, Gala MK, Kedrin D, Sridharan G, Goodman RP, Garber JJ, Masia R, Diagacomo E, Adams D, King KR, Piaker S, Reinecker HC, Yarmush ML, Argemi J, Bataller R, Dienstag JL, Chung RT, Patel SJ. Hepatic gap junctions amplify alcohol liver injury by propagating cGAS-mediated IRF3 activation. Proc Natl Acad Sci U S A. 2020;117(21):11667-73. Epub 2020/05/13. doi: 10.1073/pnas.1911870117. PubMed PMID: 32393626; PMCID: PMC7261084.
Hopke A, Scherer A, Kreuzburg S, Abers MS, Zerbe CS, Dinauer MC, Mansour MK, Irimia D. Publisher Correction: Neutrophil swarming delays the growth of clusters of pathogenic fungi. Nat Commun. 2020;11(1):2492. Epub 2020/05/16. doi: 10.1038/s41467-020-16446-8. PubMed PMID: 32409681; PMCID: PMC7224198.
Wang X, Hossain M, Bogoslowski A, Kubes P, Irimia D. Chemotaxing neutrophils enter alternate branches at capillary bifurcations. Nat Commun. 2020;11(1):2385. Epub 2020/05/15. doi: 10.1038/s41467-020-15476-6. PubMed PMID: 32404937; PMCID: PMC7220926.
Mutlu BR, Dubash T, Dietsche C, Mishra A, Ozbey A, Keim K, Edd JF, Haber DA, Maheswaran S, Toner M. In-flow measurement of cell-cell adhesion using oscillatory inertial microfluidics. Lab Chip. 2020;20(9):1612-20. Epub 2020/04/18. doi: 10.1039/d0lc00089b. PubMed PMID: 32301448; PMCID: PMC7495683.
Bulutoglu B, Devalliere J, Deng SL, Acun A, Kelangi SS, Uygun BE, Yarmush ML. Tissue scaffolds functionalized with therapeutic elastin-like biopolymer particles. Biotechnol Bioeng. 2020;117(5):1575-83. Epub 2020/01/21. doi: 10.1002/bit.27283. PubMed PMID: 31956985; PMCID: PMC7148187.
Frydman GH, Tessier SN, Wong KHK, Vanderburg CR, Fox JG, Toner M, Tompkins RG, Irimia D. Megakaryocytes contain extranuclear histones and may be a source of platelet-associated histones during sepsis. Sci Rep. 2020;10(1):4621. Epub 2020/03/14. doi: 10.1038/s41598-020-61309-3. PubMed PMID: 32165642; PMCID: PMC7067782.
Zhang W, Das P, Kelangi S, Bei M. Potassium channels as potential drug targets for limb wound repair and regeneration. Precis Clin Med. 2020;3(1):22-33. Epub 2020/04/08. doi: 10.1093/pcmedi/pbz029. PubMed PMID: 32257531; PMCID: PMC7093894.
Zhang A, Carroll C, Raigani S, Karimian N, Huang V, Nagpal S, Beijert I, Porte RJ, Yarmush M, Uygun K, Yeh H. Tryptophan Metabolism via the Kynurenine Pathway: Implications for Graft Optimization during Machine Perfusion. J Clin Med. 2020;9(6). Epub 2020/06/19. doi: 10.3390/jcm9061864. PubMed PMID: 32549246; PMCID: PMC7355886.
de Vries RJ, Tessier SN, Banik PD, Nagpal S, Cronin SEJ, Ozer S, Hafiz EOA, van Gulik TM, Yarmush ML, Markmann JF, Toner M, Yeh H, Uygun K. Subzero non-frozen preservation of human livers in the supercooled state. Nat Protoc. 2020;15(6):2024-40. Epub 2020/05/21. doi: 10.1038/s41596-020-0319-3. PubMed PMID: 32433625.
Mishra A, Dubash TD, Edd JF, Jewett MK, Garre SG, Karabacak NM, Rabe DC, Mutlu BR, Walsh JR, Kapur R, Stott SL, Maheswaran S, Haber DA, Toner M. Ultrahigh-throughput magnetic sorting of large blood volumes for epitope-agnostic isolation of circulating tumor cells. Proc Natl Acad Sci U S A. 2020;117(29):16839-47. Epub 2020/07/10. doi: 10.1073/pnas.2006388117. PubMed PMID: 32641515; PMCID: PMC7382214.
Jaskiewicz JJ, Sevenler D, Swei AA, Widmer G, Toner M, Tzipori S, Sandlin RD. Cryopreservation of infectious Cryptosporidium parvum oocysts achieved through vitrification using high aspect ratio specimen containers. Sci Rep. 2020;10(1):11711. Epub 2020/07/18. doi: 10.1038/s41598-020-68643-6. PubMed PMID: 32678171; PMCID: PMC7366687.
de Vries RJ, Pendexter CA, Cronin SEJ, Marques B, Hafiz EOA, Muzikansky A, van Gulik TM, Markmann JF, Stott SL, Yeh H, Toner M, Uygun K, Tessier SN. Cell release during perfusion reflects cold ischemic injury in rat livers. Sci Rep. 2020;10(1):1102. Epub 2020/01/26. doi: 10.1038/s41598-020-57589-4. PubMed PMID: 31980677; PMCID: PMC6981218.
Huang V, Karimian N, Detelich D, Raigani S, Geerts S, Beijert I, Fontan FM, Aburawi MM, Ozer S, Banik P, Lin F, Karabacak M, Hafiz EOA, Porte RJ, Uygun K, Markmann JF, Yeh H. Split-Liver Ex Situ Machine Perfusion: A Novel Technique for Studying Organ Preservation and Therapeutic Interventions. J Clin Med. 2020;9(1). Epub 2020/01/23. doi: 10.3390/jcm9010269. PubMed PMID: 31963739; PMCID: PMC7019984.
Mahboub P, Aburawi M, Karimian N, Lin F, Karabacak M, Fontan F, Tessier SN, Markmann J, Yeh H, Uygun K. The efficacy of HBOC-201 in ex situ gradual rewarming kidney perfusion in a rat model. Artif Organs. 2020;44(1):81-90. Epub 2019/08/02. doi: 10.1111/aor.13534. PubMed PMID: 31368159; PMCID: PMC6916591.
Edd JF, Mishra A, Dubash TD, Herrera S, Mohammad R, Williams EK, Hong X, Mutlu BR, Walsh JR, Machado de Carvalho F, Aldikacti B, Nieman LT, Stott SL, Kapur R, Maheswaran S, Haber DA, Toner M. Microfluidic concentration and separation of circulating tumor cell clusters from large blood volumes. Lab Chip. 2020;20(3):558-67. Epub 2020/01/15. doi: 10.1039/c9lc01122f. PubMed PMID: 31934715; PMCID: PMC7469923.
Huang H, Rey-Bedón C, Yarmush ML, Usta OB. Deep-supercooling for extended preservation of adipose-derived stem cells. Cryobiology. 2020;92:67-75. Epub 2019/11/22. doi: 10.1016/j.cryobiol.2019.11.004. PubMed PMID: 31751557; PMCID: PMC7195234.
Raigani S, De Vries RJ, Uygun K, Yeh H. Pumping new life into old ideas: Preservation and rehabilitation of the liver using ex situ machine perfusion. Artif Organs. 2020;44(2):123-8. Epub 2019/11/07. doi: 10.1111/aor.13579. PubMed PMID: 31691326.
Yonker LM, Neilan AM, Bartsch Y, Patel AB, Regan J, Arya P, Gootkind E, Park G, Hardcastle M, St John A, Appleman L, Chiu ML, Fialkowski A, De la Flor D, Lima R, Bordt EA, Yockey LJ, D'Avino P, Fischinger S, Shui JE, Lerou PH, Bonventre JV, Yu XG, Ryan ET, Bassett IV, Irimia D, Edlow AG, Alter G, Li JZ, Fasano A. Pediatric Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Clinical Presentation, Infectivity, and Immune Responses. J Pediatr. 2020;227:45-52.e5. Epub 2020/08/23. doi: 10.1016/j.jpeds.2020.08.037. PubMed PMID: 32827525; PMCID: PMC7438214.
Wu CW, Tessier SN, Storey KB. Dehydration stress alters the mitogen-activated-protein kinase signaling and chaperone stress response in Xenopus laevis. Comp Biochem Physiol B Biochem Mol Biol. 2020;246-247:110461. Epub 2020/06/05. doi: 10.1016/j.cbpb.2020.110461. PubMed PMID: 32497588.
Hafiz EOA, Bulutoglu B, Mansy SS, Chen Y, Abu-Taleb H, Soliman SAM, El-Hindawi AAF, Yarmush ML, Uygun BE. Development of liver microtissues with functional biliary ductular network. Biotechnol Bioeng. 2020. Epub 2020/08/29. doi: 10.1002/bit.27546. PubMed PMID: 32856740.
Frydman GH, Olaleye D, Annamalai D, Layne K, Yang I, Kaafarani HMA, Fox JG. Manuka honey microneedles for enhanced wound healing and the prevention and/or treatment of Methicillin-resistant Staphylococcus aureus (MRSA) surgical site infection. Sci Rep. 2020;10(1):13229. Epub 2020/08/09. doi: 10.1038/s41598-020-70186-9. PubMed PMID: 32764604; PMCID: PMC7414039.
Hopke A, Scherer A, Kreuzburg S, Abers MS, Zerbe CS, Dinauer MC, Mansour MK, Irimia D. Neutrophil swarming delays the growth of clusters of pathogenic fungi. Nat Commun. 2020;11(1):2031. Epub 2020/04/29. doi: 10.1038/s41467-020-15834-4. PubMed PMID: 32341348; PMCID: PMC7184738.
Olanrewaju AO, Sullivan BP, Zhang JY, Bender AT, Sevenler D, Lo TJ, Fernandez-Suarez M, Drain PK, Posner JD. Enzymatic Assay for Rapid Measurement of Antiretroviral Drug Levels. ACS Sens. 2020;5(4):952-9. Epub 2020/04/07. doi: 10.1021/acssensors.9b02198. PubMed PMID: 32248685; PMCID: PMC7183420.
Ruspita I, Das P, Xia Y, Kelangi S, Miyoshi K, Noma T, Snead ML, D'Souza RN, Bei M. An Msx2-Sp6-Follistatin Pathway Operates During Late Stages of Tooth Development to Control Amelogenesis. Front Physiol. 2020;11:582610. Epub 2020/11/17. doi: 10.3389/fphys.2020.582610. PubMed PMID: 33192593; PMCID: PMC7649293.
Raigani S, Karimian N, Huang V, Zhang AM, Beijert I, Geerts S, Nagpal S, Hafiz EOA, Fontan FM, Aburawi MM, Mahboub P, Markmann JF, Porte RJ, Uygun K, Yarmush M, Yeh H. Metabolic and lipidomic profiling of steatotic human livers during ex situ normothermic machine perfusion guides resuscitation strategies. PLoS One. 2020;15(1):e0228011. Epub 2020/01/25. doi: 10.1371/journal.pone.0228011. PubMed PMID: 31978172; PMCID: PMC6980574.
Raigani S, Carroll C, Griffith S, Pendexter C, Rosales I, Deirawan H, Beydoun R, Yarmush M, Uygun K, Yeh H. Improvement of steatotic rat liver function with a defatting cocktail during ex situ normothermic machine perfusion is not directly related to liver fat content. PLoS One. 2020;15(5):e0232886. Epub 2020/05/13. doi: 10.1371/journal.pone.0232886. PubMed PMID: 32396553; PMCID: PMC7217452.
Kalinich M, Kwan TT, Toner M, Haber DA, Maheswaran S. Quantitative Analysis of Circulating Tumor Cells Using RNA-Based Digital Scoring. Recent Results Cancer Res. 2020;215:77-88. Epub 2019/10/13. doi: 10.1007/978-3-030-26439-0_4. PubMed PMID: 31605224.
Hopke A, Irimia D. Ex Vivo Human Neutrophil Swarming Against Live Microbial Targets. Methods Mol Biol. 2020;2087:107-16. Epub 2019/11/16. doi: 10.1007/978-1-0716-0154-9_8. PubMed PMID: 31728986.
Bulutoglu B, Rey-Bedón C, Mert S, Tian L, Jang YY, Yarmush ML, Usta OB. A comparison of hepato-cellular in vitro platforms to study CYP3A4 induction. PLoS One. 2020;15(2):e0229106. Epub 2020/02/28. doi: 10.1371/journal.pone.0229106. PubMed PMID: 32106230; PMCID: PMC7046200.
Babatunde KA, Yesodha Subramanian B, Ahouidi AD, Martinez Murillo P, Walch M, Mantel PY. Role of Extracellular Vesicles in Cellular Cross Talk in Malaria. Front Immunol. 2020;11:22. Epub 2020/02/23. doi: 10.3389/fimmu.2020.00022. PubMed PMID: 32082312; PMCID: PMC7005784.
Sevenler, D., Bardon, A., Fernandez Suarez, M., Marshall, L., Toner, M., Drain, P. K., & Sandlin, R. D. (2020). Immunoassay for HIV Drug Metabolites Tenofovir and Tenofovir Diphosphate. ACS infectious diseases, 10.1021/acsinfecdis.0c00010. Advance online publication.
de Vries, R. J., Tessier, S. N., Banik, P. D., Nagpal, S., Cronin, S., Ozer, S., Hafiz, E., van Gulik, T. M., Yarmush, M. L., Markmann, J. F., Toner, M., Yeh, H., & Uygun, K. (2020). Subzero non-frozen preservation of human livers in the supercooled state. Nature protocols, 10.1038/s41596-020-0319-3. Advance online publication.
Wang, X., Hossain, M., Bogoslowski, A., Kubes, P., & Irimia, D. (2020). Chemotaxing neutrophils enter alternate branches at capillary bifurcations. Nature communications, 11(1), 2385.
Raigani, S., Carroll, C., Griffith, S., Pendexter, C., Rosales, I., Deirawan, H., Beydoun, R., Yarmush, M., Uygun, K., & Yeh, H. (2020). Improvement of steatotic rat liver function with a defatting cocktail during ex situ normothermic machine perfusion is not directly related to liver fat content. PloS one, 15(5), e0232886.
Bulutoglu, B., Rey-Bedón, C., Mert, S., Tian, L., Jang, Y. Y., Yarmush, M. L., & Usta, O. B. (2020). A comparison of hepato-cellular in vitro platforms to study CYP3A4 induction. PloS one, 15(2), e0229106.
Huang H, Bedon CR, Yarmush ML, Usta OB. Deep-supercooling for extended preservation of adipose-derived stem cells. Cryobiology. 2019 Nov 18. pii: S0011-2240(19)30205-6. doi: 10.1016/j.cryobiol.2019.11.004. [Epub ahead of print] PMID: 31751557
Rubin AE, Usta OB, Schloss R, Yarmush M, Golberg A. Selective Inactivation of Pseudomonas aeruginosa and Staphylococcus epidermidis with Pulsed Electric Fields and Antibiotics. Adv Wound Care (New Rochelle). 2019 Apr 1;8(4):136-148. doi: 10.1089/wound.2018.0819. Epub 2019 Apr 3. PMID: 31737412
Kang YBA, Eo J, Bulutoglu B, Yarmush ML, Berk Usta O. Progressive Hypoxia-on-a-Chip: An In Vitro Oxygen Gradient Model for Capturing the Effects of Hypoxia on Primary Hepatocytes in Health and Disease. Biotechnol Bioeng. 2019 Nov 18. doi: 10.1002/bit.27225. [Epub ahead of print] PMID: 31736056
Hopke A, Irimia D. Ex Vivo Human Neutrophil Swarming Against Live Microbial Targets. Methods Mol Biol. 2020;2087:107-116. doi: 10.1007/978-1-0716-0154-9_8. PMID: 31728986
Gokduman K. Sensitization of cisplatin-resistant ovarian cancer cells by magnetite iron oxide nanoparticles: an in vitro study. Nanomedicine (Lond). 2019 Nov 14. doi: 10.2217/nnm-2019-0126. [Epub ahead of print] PMID: 31724481
de Vries RJ, Banik PD, Nagpal S, Weng L, Ozer S, van Gulik TM, Toner M, Tessier SN, Uygun K. Bulk Droplet Vitrification for Primary Hepatocyte Preservation. J Vis Exp. 2019 Oct 25;(152). doi: 10.3791/60250. PMID: 31710044
Raigani S, De Vries RJ, Uygun K, Yeh H. Rapid maturation of the hepatic cell line Huh7 via CDK inhibition for PXR dependent CYP450 metabolism and induction. Artif Organs. 2019 Nov 5. doi: 10.1111/aor.13579. [Epub ahead of print] PMID: 31691326
Bulutoglu B, Mert S, Rey-Bedón C, Deng SL, Yarmush ML, Usta OB. Rapid maturation of the hepatic cell line Huh7 via CDK inhibition for PXR dependent CYP450 metabolism and induction. Sci Rep. 2019 Nov 1;9(1):15848. doi: 10.1038/s41598-019-52174-w. PMID: 31676845
Karimian N, Raigani S, Huang V, Nagpal S, Hafiz EOA, Beijert I, Mahboub P, Porte RJ, Uygun K, Yarmush M, Yeh H. Subnormothermic Machine Perfusion of Steatotic Livers Results in Increased Energy Charge at the Cost of Anti-Oxidant Capacity Compared to Normothermic Perfusion. Metabolites. 2019 Oct 24;9(11). pii: E246. doi: 10.3390/metabo9110246. PMID: 31652927
Park J, Baik SH, Mook-Jung I, Irimia D, Cho H. Mimicry of Central-Peripheral Immunity in Alzheimer's Disease and Discovery of Neurodegenerative Roles in Neutrophil. Front Immunol. 2019 Sep 25;10:2231. doi: 10.3389/fimmu.2019.02231. eCollection 2019.PMID: 31611872
Tessier SN, Weng L, Moyo WD, Au SH, Wong KHK, Angpraseuth C, Stoddard AE, Lu C, Nieman LT, Sandlin RD, Uygun K, Stott SL, Toner M. Effect of Ice Nucleation and Cryoprotectants during High Subzero-Preservation in Endothelialized Microchannels. ACS Biomater Sci Eng. 2018 Aug 13;4(8):3006-3015. doi: 10.1021/acsbiomaterials.8b00648. Epub 2018 Jun 26. PMID: 31544149
Childers CL, Tessier SN, Storey KB. The heart of a hibernator: EGFR and MAPK signaling in cardiac muscle during the hibernation of thirteen-lined ground squirrels, Ictidomys tridecemlineatus. PeerJ. 2019 Sep 5;7:e7587. doi: 10.7717/peerj.7587. eCollection 2019. PMID: 31534849
de Vries RJ, Tessier SN, Banik PD, Nagpal S, Cronin SEJ, Ozer S, Hafiz EOA, van Gulik TM, Yarmush ML, Markmann JF, Toner M, Yeh H, Uygun K. Supercooling extends preservation time of human livers. Nat Biotechnol. 2019 Oct;37(10):1131-1136. doi: 10.1038/s41587-019-0223-y. Epub 2019 Sep 9. PMID: 31501557 [PubMed - in process]
Cavalcante LDS, Toner M, Uygun K, Tessier SN. Leveraging the zebrafish to model organ transplantation. Curr Opin Organ Transplant. 2019 Oct;24(5):613-619. doi: 10.1097/MOT.0000000000000696. PMID: 31483338
Bulutoglu B, Rey-Bedón C, Kang YBA, Mert S, Yarmush ML, Usta OB. A microfluidic patterned model of non-alcoholic fatty liver disease: applications to disease progression and zonation. Lab Chip. 2019 Sep 10;19(18):3022-3031. doi: 10.1039/c9lc00354a.
de Vries RJ, Yarmush M, Uygun K. Systems engineering the organ preservation process for transplantation. Curr Opin Biotechnol. 2019 Aug;58:192-201. doi: 10.1016/j.copbio.2019.05.015. Epub 2019 Jul 4. Review. PMID: 31280087
Li L, Gokduman K, Gokaltun A, Yarmush ML, Usta OB. A microfluidic 3D hepatocyte chip for hepatotoxicity testing of nanoparticles. Nanomedicine (Lond). 2019 Aug;14(16):2209-2226. doi: 10.2217/nnm-2019-0086. Epub 2019 Jun 10. PMID:31179822
Mahboub P, Aburawi M, Karimian N, Lin F, Karabacak M, Fontan F, Tessier SN, Markmann J, Yeh H, Uygun K. The efficacy of HBOC-201 in ex situ gradual rewarming kidney perfusion in a rat model. Artif Organs. 2019 Jul 10. doi: 10.1111/aor.13534. [Epub ahead of print]
Yeh H, Uygun K. Increasing Donor Liver Utilization Through Machine Perfusion. Hepatology. 2019 Jul;70(1):431-433. doi: 10.1002/hep.30523. Epub 2019 Mar 18. No abstract available. PMID: 30681724
Geerts S, Ozer S, Chu C, Fuchs BC, Tanabe KK, Yeh H, Uygun K. Exploring donor demographics effects on hepatocyte yield and viability: Results of whole human liver isolation from one center. PMID: 31414037 [PubMed] Free PMC Article
Chen Y, Devalliere J, Bulutoglu B, Yarmush ML, Uygun BE. Repopulation of intrahepatic bile ducts in engineered rat liver grafts. Technology (Singap World Sci). 2019 Mar-Jun;7(1-2):46-55. doi: 10.1142/S2339547819500043. Epub 2019 Jun 28. PMID: 31388515 [PubMed] Free PMC Article
Ligorio M, Sil S, Malagon-Lopez J, Nieman LT, Misale S, Di Pilato M, Ebright RY, Karabacak MN, Kulkarni AS, Liu A, Vincent Jordan N, Franses JW, Philipp J, Kreuzer J, Desai N, Arora KS, Rajurkar M, Horwitz E, Neyaz A, Tai E, Magnus NKC, Vo KD, Yashaswini CN, Marangoni F, Boukhali M, Fatherree JP, Damon LJ, Xega K, Desai R, Choz M, Bersani F, Langenbucher A, Thapar V, Morris R, Wellner UF, Schilling O, Lawrence MS, Liss AS, Rivera MN, Deshpande V, Benes CH, Maheswaran S, Haber DA, Fernandez-Del-Castillo C, Ferrone CR, Haas W, Aryee MJ, Ting DT. Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer. Cell. 2019 Jun 27;178(1):160-175.e27. doi: 10.1016/j.cell.2019.05.012. Epub 2019 May 30. PMID: 31155233
Yan C, Brunson DC, Tang Q, Do D, Iftimia NA, Moore JC, Hayes MN, Welker AM, Garcia EG, Dubash TD, Hong X, Drapkin BJ, Myers DT, Phat S, Volorio A, Marvin DL, Ligorio M, Dershowitz L, McCarthy KM, Karabacak MN, Fletcher JA, Sgroi DC, Iafrate JA, Maheswaran S, Dyson NJ, Haber DA, Rawls JF, Langenau DM. Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish.. Cell. 2019 Jun 13;177(7):1903-1914.e14. doi: 10.1016/j.cell.2019.04.004. Epub 2019 Apr 25. PMID: 31031007
Ellett F, Jalali F, Marand AL, Jorgensen J, Mutlu BR, Lee J, Raff AB, Irimia D. Microfluidic arenas for war games between neutrophils and microbes. Lab Chip. 2019 Mar 27;19(7):1205-1216. doi: 10.1039/c8lc01263f. PMID: 30865740 [PubMed - indexed for MEDLINE]
Jones CN, Ellett F, Robertson AL, Forrest KM, Judice K, Balkovec JM, Springer M, Markmann JF, Vyas JM, Warren HS, Irimia D. Bifunctional Small Molecules Enhance Neutrophil Activities Against Aspergillus fumigatus in vivo and in vitro. Front Immunol. 2019 Apr 9;10:644. doi: 10.3389/fimmu.2019.00644. eCollection 2019. PMID: 31024528 [PubMed - in process] Free PMC Article
Mead BE, Karp JM. All models are wrong, but some organoids may be useful. Genome Biol. 2019 Mar 27;20(1):66. doi: 10.1186/s13059-019-1677-4. No abstract available. PMID: 30917855 [PubMed - in process] Free Article
Irimia D, Wang X. Inflammation-on-a-Chip: Probing the Immune System Ex Vivo. Trends Biotechnol. 2018 Sep;36(9):923-937. doi: 10.1016/j.tibtech.2018.03.011. Epub 2018 May 1. Review. PMID: 29728272
Kumar S, Tan Y, Yarmush ML, Dash BC, Hsia HC, Berthiaume F. Mouse Model of Pressure Ulcers After Spinal Cord Injury. J Vis Exp. 2019 Mar 9;(145). doi:10.3791/58188. PubMed PMID: 30907872.
Ellett F, Jalali F, Marand AL, Jorgensen J, Mutlu BR, Lee J, Raff AB, Irimia D. Microfluidic arenas for war games between neutrophils and microbes. Lab Chip. 2019 Mar 27;19(7):1205-1216. doi: 10.1039/c8lc01263f. PubMed PMID: 30865740.
Fuchs BB, Eatemadpour S, Martel-Foley JM, Stott S, Toner M, Mylonakis E. Rapid Isolation and Concentration of Pathogenic Fungi Using Inertial Focusing on a Chip-Based Platform. Front Cell Infect Microbiol. 2019 Feb 12;9:27. doi: 10.3389/fcimb.2019.00027. eCollection 2019. PubMed PMID: 30809512; PubMed Central PMCID: PMC6379272.
Sevenler D, Trueb J, Ünlü MS. Beating the reaction limits of biosensor sensitivity with dynamic tracking of single binding events. Proc Natl Acad Sci U S A. 2019 Feb 19. pii: 201815329. doi: 10.1073/pnas.1815329116. [Epub ahead of print] PubMed PMID: 30782809.
Tessier SN, Wu CW, Storey KB. Molecular control of protein synthesis, glucose metabolism, and apoptosis in the brain of hibernating thirteen-lined ground squirrels. Biochem Cell Biol. 2019 Feb 14. doi: 10.1139/bcb-2018-0256. [Epub ahead of print] PubMed PMID: 30763120.
de Haan L, van der Lely SJ, Warps AK, Hofsink Q, Olthof PB, de Keijzer MJ, Lionarons DA, Mendes-Dias L, Bruinsma BG, Uygun K, Jaeschke H, Farrell GC, Teoh N, van Golen RF, Li T, Heger M. Post-hepatectomy liver regeneration in the context of bile acid homeostasis and the gut-liver signaling axis. J Clin Transl Res. 2018 May 28;4(1):1-46. doi: 10.18053/jctres.04.201801.001. Epub 2018 Feb 16. PubMed PMID: 30761355; PubMed Central PMCID: PMC6370335.
Rubin AE, Levkov K, Usta OB, Yarmush M, Golberg A. IGBT-Based Pulsed Electric Fields Generator for Disinfection: Design and In Vitro Studies on Pseudomonas aeruginosa. Ann Biomed Eng. 2019 Feb 6. doi: 10.1007/s10439-019-02225-0. [Epub ahead of print] PubMed PMID: 30726513.
Wu S, Li X, Meng S, Fung T, Chan AT, Liang G, Giovannucci E, De Vivo I, Lee JH, Nan H. Fruit and vegetable consumption, cigarette smoke, and leukocyte mitochondrial DNA copy number. Am J Clin Nutr. 2019 Feb 1;109(2):424-432. doi:10.1093/ajcn/nqy286. PubMed PMID: 30721920; PubMed Central PMCID: PMC6367969.
Yeh H, Uygun K. Increasing Donor Liver Utilization Through Machine Perfusion. Hepatology. 2019 Jan 25. doi: 10.1002/hep.30523. [Epub ahead of print] PubMed PMID: 30681724.
Poster J, Chu C, Weber JM, Lydon M, Dylewski M, Uygun K, Sheridan RL. Specific Patterns of Postoperative Temperature Elevations Predict Blood Infection in Pediatric Burn Patients. J Burn Care Res. 2019 Feb 20;40(2):220-227. doi:10.1093/jbcr/irz002. PubMed PMID: 30668737; PubMed Central PMCID: PMC6382406.
Weng L, Stott SL, Toner M. Exploring Dynamics and Structure of Biomolecules, Cryoprotectants, and Water Using Molecular Dynamics Simulations: Implications for Biostabilization and Biopreservation. Annu Rev Biomed Eng. 2018 Dec 10. doi: 10.1146/annurev-bioeng-060418-052130. [Epub ahead of print] PubMed PMID: 30525930.
Lee S, Greenstein T, Shi L, Maguire T, Schloss R, Yarmush M. Tri-culture system for pro-hapten sensitizer identification and potency classification. Technology (Singap World Sci). 2018 Jun;6(2):67-74. doi: 10.1142/S233954781850005X. Epub 2018 Jun 29. PubMed PMID: 30519598; PubMed Central PMCID: PMC6276108.
LeValley PJ, Tibbitt MW, Noren B, Kharkar P, Kloxin AM, Anseth KS, Toner M, Oakey J.Immunofunctional photodegradable poly(ethylene glycol) hydrogel surfaces for the capture and release of rare cells. Colloids Surf B Biointerfaces. 2019 Feb 1;174:483-492. doi: 10.1016/j.colsurfb.2018.11.049. Epub 2018 Nov 20. PubMed PMID: 30497010.
Weng L, Lee GY, Liu J, Kapur R, Toth TL, Toner M. On-chip oocyte denudation from cumulus-oocyte complexes for assisted reproductive therapy. Lab Chip. 2018 Dec 4;18(24):3892-3902. doi: 10.1039/c8lc01075g. PubMed PMID: 30465050; PubMed Central PMCID: PMC6335650.
Otawara M, Roushan M, Wang X, Ellett F, Yu YM, Irimia D. Microfluidic Assay Measures Increased Neutrophil Extracellular Traps Circulating in Blood after Burn Injuries. Sci Rep. 2018 Nov 19;8(1):16983. doi: 10.1038/s41598-018-34952-0. PubMed PMID: 30451882; PubMed Central PMCID: PMC6242863.
Martins PN, Berendsen TA, Yeh H, Bruinsma BG, Izamis ML, Op den Dries S, Gillooly AR, Porte R, Yarmush ML, Uygun K, Markmann JF. Oxygenated UW Solution Decreases ATP Decay and Improves Survival After Transplantation of DCD Liver Grafts. Transplantation. 2019 Feb;103(2):363-370. doi: 10.1097/TP.0000000000002530. PubMed PMID: 30422952.
Li X, Saeidi N, Villiger M, Albadawi H, Jones JD, Quinn KP, Austin WG Jr, Golberg A, Yarmush ML. Rejuvenation of aged rat skin with pulsed electric fields. J Tissue Eng Regen Med. 2018 Dec;12(12):2309-2318. doi: 10.1002/term.2763. Epub 2018 Nov 22. PubMed PMID: 30353675.
Ellett F, Jorgensen J, Marand AL, Liu YM, Martinez MM, Sein V, Butler KL, Lee J, Irimia D. Diagnosis of sepsis from a drop of blood by measurement of spontaneous neutrophil motility in a microfluidic assay. Nat Biomed Eng. 2018 Apr;2(4):207-214. doi: 10.1038/s41551-018-0208-z. Epub 2018 Mar 19. PubMed PMID: 30283724; PubMed Central PMCID: PMC6166236.
Bhan I, Mosesso K, Goyal L, Philipp J, Kalinich M, Franses JW, Choz M, Oklu R, Toner M, Maheswaran S, Haber DA, Zhu AX, Chung RT, Aryee M, Ting DT. Detection and Analysis of Circulating Epithelial Cells in Liquid Biopsies From Patients With Liver Disease. Gastroenterology. 2018 Dec;155(6):2016-2018.e11. doi:10.1053/j.gastro.2018.09.020. Epub 2018 Sep 13. PubMed PMID: 30218669; PubMed Central PMCID: PMC6347478.
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