Parkinson's disease is a progressive neurological disorder that causes tremors, movement difficulties, and balance problems. Doctors typically diagnose it through a careful review of symptoms and a neurological exam, with additional tests sometimes ordered to help with the diagnosis. While there is no cure, Parkinson's treatments can help manage symptoms and maintain a good quality of life for as long as possible.

How Is Parkinson's Diagnosed?

There's no definitive test to diagnose Parkinson's disease (PD). Diagnosis is typically made by a neurologist who will evaluate your Parkinson's disease symptoms, medical history, and family history. They'll also perform physical and neurological exams and may order other tests to rule out other conditions. In some cases, a special brain imaging study that looks at dopamine activity can be helpful.

Learn about Parkinson's Symptoms & Causes

Sometimes, doctors use Parkinson's medications as a diagnostic tool—if your symptoms improve during a trial period, it can indicate that you may have Parkinson's.

Physicians at the Mass General Parkinson's Disease Center of Excellence are highly trained in the diagnosis and treatment of Parkinson’s disease. Learn more by requesting an appointment.

Is There a Blood Test for Parkinson's Disease?

Currently, there are no blood tests that can detect Parkinson's disease. However, your care team may perform blood tests to rule out other conditions with similar symptoms.

Can Parkinson’s Be Diagnosed with MRI or CT Scans?

Like blood tests, MRI and CT scans aren’t useful in diagnosing Parkinson's directly. However, they may be used to rule out other potential causes of your symptoms, leading to a diagnosis by exclusion.

What Is a DaTscan?

Parkinson's symptoms are caused by decreased levels of dopamine in the brain. The DaT test for Parkinson's involved injecting a medicinal dye to measure the activity of dopamine-producing brain cells. While it can't provide a definitive Parkinson’s diagnosis, it may help support one.

How Is Parkinson’s Treated?

While there are no medications to slow the progression of Parkinson’s, effective treatments are available to help manage symptoms and improve quality of life.

Parkinson's Disease Medications

Medications for Parkinson's work by increasing dopamine levels in the brain or mimicking its effects.The most effective Parkinson's medication is carbidopa-levodopa. Levodopa, a natural chemical, that converts into dopamine in the brain, while carbidopa helps it reach the brain more effectively and reduces side effects like nausea. Typically, your care team will start you on a low dose of levodopa to minimize side effects, with the possibility of increasing the dose over time as needed.

Other Parkinson's disease medications include:

  • Dopamine agonists: These drugs stimulate dopamine production. Although less effective than levodopa, they can help manage symptoms. However, they may cause more side effects, including strange or compulsive behaviors. Speak with your doctor if you notice any unusual behaviors while taking these.
  • A2A receptor antagonists: These medications block the activity of a different brain chemical called adenosine, and can help improve Parkinson’s symptoms.
  • Enzyme inhibitors: Enzymes in the brain break down dopamine or levodopa. Enzyme inhibitors, such as COMT (catechol-O-methyl transferase) and MAO-B (monoamine oxidase B) inhibitors, slow this process, helping the medication last longer in the system.
  • Anticholinergics: These drugs block acetylcholine, another neurotransmitter, to help control tremors. Due to their side effects, they are used less frequently today.
  • Amantadine: This medication can help manage involuntary movements (dyskinesias) caused by Parkinson’s or PD medications. It is often used as the disease progresses.

Parkinson's Disease Surgery

While there is no surgery to cure Parkinson's disease, a technique called deep brain stimulation (DBS) can help when medications no longer control symptoms effectively. In this procedure, surgeons implant electrodes into the brain areas affected by Parkinson's and connect them to a stimulator implanted under the skin near the collarbone. These electrodes send electrical pulses to stimulate the brain, which can reduce symptoms.

What New Treatments Are Being Developed for Parkinson's Disease?

There are exciting new developments in Parkinson's disease treatment, including:

  • Stem cell treatment: Experimental treatments aimed at replacing damaged dopamine-producing neurons with stem cells.
  • Neuronal repair: An experimental approach to repair damaged neurons or stimulate the brain to build new ones.
  • Gene therapy: Since some Parkinson's cases are hereditary, gene therapy aims to target and correct the genetic mutations responsible for the disease.

FAQs About Parkinson's Disease Treatment

Can Parkinson's disease be cured?

Unfortunately, there is no known cure for Parkinson's disease. Treatment can help you manage your symptoms and live independently for longer, but it can't slow or stop the overall progression of the disease.

What are effective strategies for Parkinson's disease self-care?

Receiving a Parkinson's diagnosis can be devastating news. Taking care of yourself and promoting your brain health can help you navigate life with Parkinson's and help keep the disease from progressing faster than necessary. Self-care habits for Parkinson's disease include:

  • Exercise: Getting enough physical activity can help maintain your motor abilities. Studies show that exercise can help slow the progression of Parkinson’s diseases symptoms. Focus on getting a mix of aerobic activity, resistance training, flexibility/stretching, and balance practice to counteract the symptoms of Parkinson's disease. Current guidelines suggest trying to do 2 ½ hours of moderate to vigorous exercise per week.
  • Diet: A healthy diet can help slow the progression of Parkinson's. Focus on fresh produce, non-fried fish, nuts and seeds, fresh herbs, and healthy oils like olive and coconut oil.
  • Support: Depression and feelings of isolation are common among people with Parkinson's. It can help to join a support group, talk to friends and family, or see a therapist.
  • Hydration: Getting enough water is essential for your brain health. Dehydration can worsen Parkinson's symptoms like stiffness or slow movement.
  • Stress management: Stress is known to worsen Parkinson's symptoms. Learning to manage stress through meditation, deep breathing, yoga, and similar methods can help. Tai chi, a traditional Chinese exercise focusing on slow, controlled movement, is helpful in managing stress, depression, and anxiety and is also effective in helping you maintain your balance.
What is the first thing to do if you have Parkinson's disease?

Proper care is crucial. Seek care with a neurologist who you will work with to monitor and treat your symptoms. Speak to your doctor or neurologist about lifestyle changes that can help and ask about when it's appropriate for you to start treatment with levodopa. If your symptoms are mild and don't interfere with daily life, you may decide to wait.

What is the life expectancy with Parkinson's disease?

Despite the difficulties that Parkinson's symptoms cause in daily life, PD is rarely a cause of death. Most people with Parkinson's live as long as the general population, though they may need assistance with daily activities as the condition worsens.

What lifestyle changes should I make?

Parkinson's is a progressive disease, so it will get worse with time. Lifestyle factors can help you manage your symptoms and improve your quality of life. You can improve your life by:

What foods should people with Parkinson's avoid?

There is not a specific Parkinson’s diet, but it is best to keep a healthy, balanced diet. A Mediterranean diet is rich in nutrients that help brain health, and may be helpful for people with Parkinson’s and other brain conditions.

Is coffee good for Parkinson's disease?

Some studies show that caffeine may delay the onset of PD.

Is there a natural cure for Parkinson's disease?

There is no known cure for Parkinson's disease. The primary treatment for PD symptoms uses medicines to help your brain make more dopamine.

What can mimic Parkinson's disease?

A number of other conditions present similar symptoms to Parkinson's disease, including:

  • Corticobasal syndrome: Like Parkinson's, corticobasal syndrome can cause issues with balance, movement, and swallowing.
  • Dementia with Lewy bodies: Lewy bodies are found in the brain cells of people with both Parkinson’s and dementia with Lewy bodies. Lewy bodies are abnormal clumps of alpha-synuclein, a protein in the brain. In dementia with Lewy bodies, cognitive problems start around the same time as motor symptoms, whereas in Parkinson’s, dementia usually develops later.
  • Multiple system atrophy (MSA): MSA shares symptoms that resemble Parkinson's, including tremor, stiffness, and problems with coordination. It can also affect the autonomic nervous system, leading to problems with blood pressure, urination, and sexual function.
  • Progressive supranuclear palsy (PSP): PSP shares many of the same symptoms as Parkinson's but typically progresses faster and causes issues with eye movements and early falls, which are less common in Parkinson's.
  • Essential tremor: Essential tremor is not a form of Parkinsonism. Essential tremor causes rhythmic shaking, often in the hands, head, legs, or voice. Shaking in essential tremor is usually more pronounced when using the hands, unlike Parkinson’s where the tremor is often worse when the hand or leg is at rest.
  • Huntington's Disease: Huntington’s can cause chorea, a movement disorder that causes involuntary movements. Chorea causes bigger, less rhythmic movements than Parkinson’s.
  • Normal pressure hydrocephalus (NPH): Caused by excessive cerebrospinal fluid in the brain, NPH can mimic symptoms of multiple neurological conditions, including dementia and difficulty walking, similar to Parkinson’s disease.