Eichler Lab: Florian Eichler, MD

Overview

The Eichler lab is exploring the relationship of mutant genes to specific biochemical defects and their contribution to neurodegeneration. Clinical research studies have defined disease progression in adrenoleukodystrophy, metachromatic leukodystrophy and Tay Sachs Disease. Read more on Dr. Eichler's website.

Research Projects

Hereditary Sensory Autonomic Neuropathy, Type1 (HSAN1)

Current research is focused on a novel treatment for the disorder with the amino acid L-serine. Clinical trials indicate that L-serine, taken three times a day, can drastically lower the neurotoxic lipids that are the hallmark of HSAN1. Read more >

 X-linked Adrenoleukodystrophy (X-ALD)

Our lab studies the ABCD1 gene that is responsible for X-ALD to better understand potential mechanisms of disease onset. Read more >.

GM2 Gangliosidoses (Tay Sachs)

Our lab is defining the pace and rate of clinical decline in GM2 gangliosidosis in preparation for a first gene therapy trial for this disorder. Read more >.

Research Positions

Read about and apply for residency, fellowship and observership programs in neurology.

All applicants should register with the Mass General Careers Web site.

Publications

NCBI PubMed Publications - Eichler, FS

NCBI PubMed Publications - Eichler, F