Research Spotlight: Factors Contributing to Treatment Resistance in CAR T Therapies for Solid Tumors
Researchers used a unique 3D microfluidic model of tumors to investigate the mechanisms of treatment resistance to CAR-T cells.
Hospital-Wide Research Programs
Research at Massachusetts General Hospital includes multitude of hospital-wide centers, institutes and programs as well as collaborations with other institutions.
Multi-Departmental Centers
Thematic Centers
Multi-Institutional Centers
- Athinoula A. Martinos Center for Biomedical Imaging
- Center for the Integration of Medicine and Innovative Technology (CIMIT)
- Center for Genomics, Vulnerable Populations and Health Disparities
- Center for Molecular Imaging Research (CMIR)
- Gordon Center for Medical Imaging
- Home Base Program
- MGH and BWH Center for Clinical Data Science
- Ragon Institute of MGH, Harvard and MIT
Clinical and Translational Research
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Research Spotlight: Comparing the GI Side Effects of Four Medications for Alcohol Use Disorder
Researchers found that injectable naltrexone had the fewest reported GI and liver-related side effects compared to the other drugs.
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Research Spotlight: How Microbes in the Human Gut Swap Genetic Traits
Researchers found that genetic swaps in the gut microbiome are occurring much more frequently than previously thought and detected more than 100,000 swaps that hadn’t been seen before.
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Research Spotlight: Improving Liver Cancer Outcomes Through Enhanced Immunotherapy
Dan G. Duda, DMD, PhD, is the corresponding author of a paper published in Cancer Immunology Research, “Combination CXCR4 and PD1 Blockade Enhances Intratumoral Dendritic Cell Activation and Immune Responses Against Hepatocellular Carcinoma.”
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Research Spotlight: Interplay Between Immune Cells and HPV Keeps Skin Healthy
Shadmehr (Shawn) Demehri, MD, PhD, is the corresponding author of a paper published in Cancer Cell, “Commensal papillomavirus immunity preserves the homeostasis of highly mutated normal skin.”
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Research Spotlight: Learning More About How Astrocytes Change as a Result of Alzheimer’s Disease
A deeper understanding of astrocytes’ roles is essential for developing targeted therapies to manage or prevent Alzheimer's disease.
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