Interdisciplinary Brain Center (IBC)
Interdisciplinary Brain Center
About the Center
Our center is dedicated to enhancing brain health through a holistic approach that encompasses emotional well-being and considers social and environmental factors. Our interdisciplinary team consists of neurologists, psychiatrists, geriatricians, gerontologists, social workers, AI/machine learning specialists, computer scientists, engineers, and data scientists. This diverse expertise enables us to adopt interdisciplinary approaches to our work.
Our Research
Our research encompasses the discovery, development, and implementation of promising therapeutics, biomarkers and associated diagnostics for individuals with complex brain and other disorders that affect cognition, behavior, emotion, sensory and physiological functioning. We conduct proof-of-concept studies, Phase 1b through Phase 4 clinical trials, and biomarker-intensive treatment trials. Our innovative clinical trial designs address the heterogeneity of neurocognitive disorders of aging, including non-pharmacological trials.
View select publications
- Dodge HH, Yu K, Wu CY, Pruitt PJ, Asgari M, Kaye JA, Hampstead BM, Struble L, Potempa K, Lichtenberg P, Croff R, Albin RL, Silbert LC; I-CONECT team. Internet-based Conversational Engagement Randomized Controlled Clinical Trial (I-CONECT) Among Socially Isolated Adults 75+ Years Old with Normal Cognition or MCI: Topline Results. Gerontologist. 2023 Nov 3:gnad147. doi: 10.1093/geront/gnad147. PMID: 37935416.
- Hollunder, B., Ostrem, J.L., Sahin, I.A. et al. Mapping Dysfunctional Circuits in the Frontal Cortex Using Deep Brain Stimulation. Nat Neurosci 27, 573–586 (2024).
- Meher R. Juttukonda, Binyin Li, Randa Almaktoum, Kimberly A. Stephens, Kathryn M. Yochim, Essa Yacoub, Randy L. Buckner, David H. Salat. Characterizing Cerebral Hemodynamics Across the Adult Lifespan with Arterial Spin Labeling MRI Data from the Human Connectome Project-Aging. NeuroImage, Volume 230, 2021, 117807, ISSN 1053-8119.
- Schwab N, Wu CY, Galler J, DeRamus T, Ford A, Gerber J, Kitchen R, Rashid B, Riley M, Sather L, Wang X, Young C, Yang L, Dodge HH, Arnold SE. Feasibility of Common, Enjoyable Game Play for Assessing Daily Cognitive Functioning in Older Adults. Front Neurol. 2023 Oct 12;14:1258216. doi: 10.3389/fneur.2023.1258216. PMID: 37900599; PMCID: PMC10602782.
- Touroutoglou A, Katsumi Y, Brickhouse M, Zaitsev A, Eckbo R, Aisen P, Beckett L, Dage JL, Eloyan A, Foroud T, Ghetti B, Griffin P, Hammers D, Jack CR Jr, Kramer JH, Iaccarino L, Joie R, Mundada NS, Koeppe R, Kukull WA, Murray ME, Nudelman K, Polsinelli AJ, Rumbaugh M, Soleimani-Meigooni DN, Toga A, Vemuri P, Atri A, Day GS, Duara R, Graff-Radford NR, Honig LS, Jones DT, Masdeu JC, Mendez MF, Musiek E, Onyike CU, Riddle M, Rogalski E, Salloway S, Sha S, Turner RS, Wingo TS, Wolk DA, Womack K, Carrillo MC, Rabinovici GD, Apostolova LG, Dickerson BC; LEADS Consortium. The Sporadic Early-onset Alzheimer's Disease Signature of Atrophy: Preliminary Findings from the Longitudinal Early-onset Alzheimer's Disease Study (LEADS) Cohort. Alzheimers Dement. 2023 Nov;19(Suppl 9):S74-S88. doi: 10.1002/alz.13466. Epub 2023 Oct 18. PMID: 37850549; PMCID: PMC10829523.
- Trombetta BA, Wu CY, Kuo E, de Geus MB, Dodge HH, Carlyle BC, Kivisäkk P, Arnold SE. Cerebrospinal Fluid Biomarker Profiling of Diverse Pathophysiological Domains in Alzheimer's Disease. Alzheimers Dement (NY). 2024 Jan 24;10(1):e12440. doi: 10.1002/trc2.12440. PMID: 38356471; PMCID: PMC10865489.
- Wang J, Jalali Motlagh N, Wang C, Wojtkiewicz GR, Schmidt S, Chau C, Narsimhan R, Kullenberg EG, Zhu C, Linnoila J, Yao Z, Chen JW. D-mannose Suppresses Oxidative Response and Blocks Phagocytosis in Experimental Neuroinflammation. Proc Natl Acad Sci USA. 2021 Nov 2;118(44):e2107663118. doi: 10.1073/pnas.2107663118. PMID: 34702739; PMCID: PMC8673064.
- Wu CY, Mattek N, Wild K, Miller LM, Kaye JA, Silbert LC, Dodge HH. Can Changes in Social Contact (Frequency and Mode) Mitigate Low Mood Before and During the COVID-19 Pandemic? The I-CONECT Project. J Am Geriatr Soc. 2022 Mar;70(3):669-676. doi: 10.1111/jgs.17607. Dec 13. PMID: 34881436; PMCID: PMC8904274.
Our Clinical Trial Core Center
Clinical & Translational Research Unit (CTRU): The CTRU research team develops and deploys novel therapeutics and diagnostics to improve the care of patients with complex brain disorders that impact cognitive, behavioral, emotional, sensory, and motor functioning.
