Dr. Paganoni is an Associate Professor at Harvard Medical School and works as a physician scientist at the Healey Center for ALS at Massachusetts General Hospital and at Spaulding Rehabilitation Hospital.Her research focuses on clinical trials and therapy development for ALS. She has served as PI of several ALS clinical trials and has been using novel trial designs, novel endpoints and digital technology tools to innovate the way investigational products are tested in ALS. She is the co-PI of the HEALEY ALS Platform Trial, the first platform trial for ALS in the world. She recently reported the positive results of the CENTAUR trial and is the co-Chair of the global PHOENIX trial.She is also working with people with Primary Lateral Sclerosis (PLS), a rare form of Motor Neuron Disease, and Hereditary Spastic Paraplegia (HSP). She co-chairs the PLS Task Force and the PLS registry of the Northeast ALS Consortium (NEALS). She is working with other Harvard researchers on developing new assistive technology devices that can improve function and quality of life for people with ALS and other forms of Motor Neuron Disease. Dr. Paganoni published >100 peer-reviewed papers. She is an editorial board member for Muscle and Nerve and the American Journal of PM&R where she is also Associate Editor for the Section Evidence-Based Physiatry/Cochrane Corner. Her research has been funded by the NIH, foundations, and industry. She received several awards for her work including the NIH Rehabilitation Medicine Scientist Training Program Award (2012), the American Academy of Neurology / ALS Association Three-Year Career Development Award in ALS (2017), the American Association of Neuromuscular & Electrodiagnostic Medicine Scientific Impact Award (2019), the Top 10 Clinical Research Achievement Award (2021), and the Martin Prize for Excellence in Clinical Research Award (2021).Dr. Paganoni holds 3 Board Certifications (Physical Medicine and Rehabilitation, Neuromuscular Medicine, and Electrodiagnostic Medicine). She is a member of the Association of Academic Physiatrists (AAP), American Academy of Neurology (AAN), and American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM).
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Sean M. Healey and AMG Center for ALS
55 Fruit Street
Wang Ambulatory Care Center
8th Floor
Boston, MA 02114
Phone: 617-724-3914
Medical Education
American Board Certifications
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Dr. Paganoni and the Team always do a wonderful job. They are professional, empathetic, listen & explain things well. In addition, they discuss the plan of care so we are all aligned. I rate them 10/10. Thank you!
Every person we were in contact with were very professional
Impressively well organized.
My ALS care team is phenomenal.
I think Dr. Paganoni has been wonderfully straightforward and clear in our discussions. I'm very grateful for her approach and for her even-handedness and for her thoughtfulness. And so I have great trust in what she has to say and I'm looking forward to continuing to work with her. So once again, I just appreciate what she's doing for me.
This was the first time that we had gone to MGH and met any of the neurology staff. Everyone was thoughtful and thorough. They asked good questions and listened to the answers. As the visit was part of the ALS Clinic, we met a variety of different providers, but Dr. Paganoni was the primary focus of our visit. We were very pleased with the entire ... Read More
She is amazingly kind and supportive. Very thorough.
I did try to get a sooner appointment but none were available
Dr. Paganoni has been fantastic to deal with since diagnosis in 2020. I can't say enough about her and her team
Dr Paganoni is wonderful!