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Personalized ALS Patient Care & Research

Our dedicated, multidisciplinary team is experienced in navigating the complexities of ALS, providing integrative, personalized ALS treatment options through our ALS care center, virtual visits, house calls, access to cutting-edge clinical trials, and expanded access to ALS clinical care programs.

As there is currently no cure for ALS, or amyotrophic lateral sclerosis, also known as Lou Gehrig’s disease, the main approach to treatment is to manage the symptoms that come with this disease. This may include physical, occupational, speech, respiratory, and nutritional therapies. There are currently few FDA therapies approved for treating ALS—riluzole, edaravone (IV and oral formulation), Relyvrio, and Nuedexta to name a few.

Our ALS Clinic offers many community resources to help support patients with ALS and their loved ones.

Researchers are conducting studies to increase their understanding of genes that may cause the disease, mechanisms that can trigger motor neurons to degenerate in ALS, and approaches to stop the progress leading to cell death.

Browse our ALS Clinic welcome packet (PDF)

Expanded Clinical Care: Meeting the Needs of our Patients with ALS

We provide personalized care for people with ALS, offering access to experimental therapies through clinical trials and expanded access programs. Through partnerships with our patients, we have steadily diversified and expanded our multidisciplinary care team, developed TelePALS (a video telehealth program), and launched the ALS House Call Program. Each program is designed to deliver the best possible ALS care directly to our patients, meeting the unique needs of those with ALS on their own terms.

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Personalized Research: ALS Care Plans Tailored to You

The impact of ALS varies for each person. At the Healey & AMG Center for ALS, we know that that understanding the distinctive needs of each individual with ALS is crucial to overcoming the disease. We embrace this uniqueness as a tool for pioneering ALS research and clinical trials to unlock the mysteries of the disease and develop effective treatments.

See our latest ALS clinical trials and research

The thoughtfulness, carefulness and caring that Sarah Luppino, NP showed meant a lot to both myself and my wife who was also in with me. She's professional, smart and very caring.

– Patient at the ALS Multidisciplinary Clinic

Frequently Asked Questions About ALS

What is ALS?

ALS, or amyotrophic lateral sclerosis, also known as Lou Gehrig’s disease, is a neuromuscular disorder affecting motor neurons. These are the nerves responsible for controlling voluntary muscles used for actions such as chewing, talking, and moving your arms and legs. Over time, ALS leads to muscle weakness, eventually impacting breathing, talking, and swallowing.

Effective ALS treatment involves a combination of therapies and medications designed to manage symptoms and slow down the progression of the disease.

How common is ALS?

ALS is the most prevalent adult-onset progressive motor neuron disease, affecting approximately 30,000 people in the U.S. and an estimated 500,000 people worldwide.

What are the early symptoms of ALS?

Early symptoms may include muscle weakness, twitching, and difficulty with speech or swallowing.

Learn more about ALS symptoms

How is ALS diagnosed?

Diagnosis involves clinical examinations, electromyography (EMG), and various imaging tests to rule out other conditions.

Learn more about ALS is diagnosed

Is there a cure for ALS?

Currently, there is no cure for ALS, but various treatments and therapies aim to manage symptoms and improve quality of life. Treatment focuses on symptom management, including medications, physical therapy, and assistive devices to enhance quality of life.

Are there risk factors for ALS?

While the exact cause is unknown, certain genetic and environmental factors may contribute to ALS risk.

Can ALS be inherited?

In some cases, ALS has a genetic component. Both sporadic and familial forms exist.

What research is being done for ALS?

Ongoing research explores potential treatments, genetic factors, and understanding the underlying causes of ALS.

Explore ALS research at Mass General

How does ALS progress?

ALS progression varies, but it typically involves the gradual degeneration of motor neurons, leading to increased muscle weakness and functional impairment.

What is the life expectancy for someone with ALS?

Life expectancy varies, but the average survival is around 3-5 years after diagnosis. However, some individuals may live longer.

Diagnosing ALS

Diagnosing ALS

We offer neuromuscular diagnostic services including, MRI, lab tests and electromyography.

Patient & Family Education

Patient & Family Education

Explore resources that are designed to help patients and families living with ALS.

Managing ALS Symptoms

Managing ALS Symptoms

Learn how identifying and managing symptoms can make living with ALS easier.

ALS PACT

ALS PACT

PACT, or Parenting At a Challenging Time, helps families cope with an ALS diagnosis.

Find an ALS Clinical Trial

Find an ALS Clinical Trial

Join us at the leading edge of ALS research.

Common Questions About Radicava

Common Questions About Radicava

Radicava (edaravone) is a relatively new drug that can slow the progression of ALS.

House Calls Program

House Calls Program

Patients can have ALS clinicians visit them at home.

TeleHealth

TeleHealth

TeleHealth helps bring the ALS clinic to your home.

ALS News

ALS News

Get the latest news from the Healey Center.

Frequently Asked Questions About ALS Care

Frequently Asked Questions About ALS Care

Explore answers to common questions about ALS care at Mass General.