Research labs at the Center for Immunology and Inflammatory Diseases at Massachusetts General Hospital.

Principal Investigators

Robert Anthony, PhD

Robert Anthony, PhD

The Anthony Laboratory investigates the role and regulation of immunoglobulin glycosylation.

Lloyd Bod, PhD

The Bod laboratory focuses on deciphering the landscape of phenotypic and functional B cell states within tumors.
Shannon Bromley, PhD

Shannon Bromley, PhD

The Bromley Laboratory investigates lymphocyte migration, with an emphasis on the mechanisms that regulate the accumulation of T cells within normal and inflamed non-lymphoid tissues.
Joseph El Khoury

Joseph El Khoury, MD

The El Khoury Laboratory investigates the role of the innate immune system in neurodegeneration, inflammation and host defense against infectious pathogens.
Rachel Knipe, MD

Rachel Knipe, MD

The Knipe Laboratory at Mass General focuses on defining the mechanisms by which endothelial injury and dysfunction contribute to the development of lung disease, particularly pulmonary fibrosis.
Andrew Luster, MD, PhD

Andrew D. Luster, MD, PhD

The Luster Laboratory investigates chemokines, lipid chemoattractants and their receptors in normal physiology and disease.
Benjamin Medoff, MD

Benjamin Medoff, MD

The Medoff Laboratory studies the pathogenesis of pulmonary inflammation in a number of important lung diseases such as asthma, COPD, lung transplant rejection and viral infections.
Thorsten Mempel, MD, PhD

Thorsten R. Mempel, MD, PhD

The Mempel Laboratory investigates cell migration and intercellular communication in the adaptive immune system through direct dynamic in vivo visualization of immune cell behavior using multiphoton intravital microscopy in mice.
James Moon, PhD

James Moon, PhD

The Moon Laboratory focuses on basic issues of CD4+ T cell tolerance studied by directly tracking antigen-specific populations in mouse and human models.
Sartia Patil, MD

Sarita Patil, MD

The Patil Laboratory is focused on the study of allergen-specific antibodies in allergic diseases.
Cory Perugino, DO

Cory Perugino, DO

The Perugino Laboratory, led by Corey Perugino, DO, investigates the antigens and adaptive immune cells driving autoimmune fibrotic diseases, focusing on systemic sclerosis (SSc) and IgG4-related disease (IgG4-RD).

Rod Rahimi, MD, PhD

The central focus of the Rahimi Laboratory is to define the mechanisms regulating CD4+ T cell responses to inhaled antigens in the context of health and disease.
Gary Reynolds, MBBS, PhD

Gary Reynolds, MBBS, PhD

The Reynolds Lab aims to better understand immune-mediated rheumatic diseases by applying multi-omic data methods, particularly in identifying immune-stromal interactions and mechanisms underlying tissue damage.
Deb Sen, PhD

Debattama Sen, PhD

Research topics include: regulation of T cell dysfunction, CD8+ T cells, epigenetic approaches for T cell engineering, immunology, systems biology and epigenomics
Wayne Shreffler

Wayne Shreffler, MD, PhD

The Shreffler Laboratory is interested in the mechanisms regulating both primary sensitization and the subsequent balance between immune progression or regulation that determines either clinical sensitivity or tolerance to mucosal allergens.
Caroline Sokol, MD, PhD

Caroline Sokol, MD, PhD

The Sokol Laboratory investigates the innate and adaptive immune interactions that initiate the allergic immune response.
Allen Steere, MD

Allen Steere, MD

The Steere Laboratory does translational studies using samples from patients with Lyme arthritis or rheumatoid arthritis to delineate mechanisms involved in the pathogenesis of these diseases, to identify biomarkers of disease activity and to develop diagnostic tests.
Alexandra-Chloe Villani, PhD

Alexandra-Chloe Villani, PhD

The Villani Lab is developing and implementing single-cell 'omics' strategies and systems immunology approaches to human immune response regulation as a foundation for deciphering human traits and diseases.

Associate Members

Donald Bloch, MD

Donald Bloch, MD

The Bloch Laboratory investigates the role of the bone morphogenetic protein signal transduction pathway in a broad spectrum of human diseases.
Nir Hacohen

Nir Hacohen, PhD

The Hacohen Laboratory develops new and unbiased strategies to understand basic immune processes and immune-mediated diseases.
Shiv Pillai

Shiv Pillai, MD, PhD

The Pillai Laboratory investigates the biology of the immune system and human genetics.
Leonardo V. Riella, MD, PhD

Leonardo V. Riella, MD, PhD

The Riella Laboratory investigates the fundamental mechanisms that regulate the immune system in order to better manage and treat transplantation patients.