Effective Therapy Identified for Improving Bone Density in Adolescent Girls with Anorexia Nervosa
A new study demonstrated for the first time an effective method of increasing bone mineral density in girls with anorexia nervosa.
About Madhusmita Misra, MD, MPH
Dr. Misra completed her fellowship in Pediatric Endocrinology at Mass General Hospital (MGH) and Masters in Public Health at the Harvard School of Public Health. She is Chief of the Division of Pediatric Endocrinology at MGfC, Associate Director of the Harvard Catalyst Translational and Clinical Research Center (MGH) and Director of the Pediatric Endocrine-Sports Endocrine-Neuroendocrine Lab (MGH). Dr. Misra has chaired the Drugs and Therapeutics Committee, the Fellow Spring Retreat, and the Research Affairs Council of the Pediatric Endocrine Society (PES). She is an ex-Director and Past President of the PES, and on the Subboard of Endocrinology for the ABP. Dr. Misra has received the William Silen Lifetime Achievement in Mentoring Award (HMS), the Outstanding Mentor Award (PES), the John Haddad Young Investigator Award (AIMM-ASBMR), the Janet W. McArthur Award (Women in Endocrinology), the Claflin Distinguished Scholar Award (MGH) and the Rita M. Kelley, MD, Fellowship (MGH).
Dr. Misra specializes in neuroendocrine and bone disorders. She is internationally known for her work on neuroendocrine, metabolic and bone complications in anorexia nervosa, exercise induced amenorrhea, obesity, and autism spectrum disorders, and her work has led to major strides in the clinical management of these conditions. Dr. Misra has a special clinical interest in pituitary disorders, and her panel includes children with some of the most complex pituitary tumors. She is associated with the multidisciplinary Neuroendocrine Clinical Center at MGH, and is often asked to provide second opinions on complex pituitary cases. In addition, Dr. Misra sees children with growth and puberty disorders, reproductive, adrenal and thyroid disorders, and children with diabetes.
Clinical Interests:
- Adolescent gynecology
- Cushing's syndrome
- Diabetes
- Diabetes Mellitus Type 1
- Disorders of calcium and bone
- Disorders of sexual differentiation
- Endocrinology
- Female athlete triad
- Growth and nutritional disorders
- Neuroendocrinology
- Pediatric endocrinology
- Pituitary disease
- Pituitary disorders
- Pubertal disorders
- Thyroid and adrenal disorders
Treats:
- Pediatrics
Languages:
- Hindi, Oriya
Locations
Mass General for Children: Pediatric Endocrine Program and Diabetes Center
55 Fruit St.
Boston, MA 02114
Phone: 617-726-2909
Medical Education
- MBBS, SCB Medical College
- Residency, Maimonides Medical Center
- Fellowship, Massachusetts General Hospital
American Board Certifications
- Pediatric Endocrinology, American Board of Pediatrics
- Pediatrics, American Board of Pediatrics
Accepted Insurance Plans
- Aetna
- Beech Street
- Blue Cross Blue Shield
- Blue Cross Blue Shield Medicare
- Cigna
- Commonwealth Care Alliance
- Coventry
- Fallon Health
- Harvard Pilgrim Health Care
- Humana
- Maine Community Health Options
- Mass General Brigham Health Plan
- MassHealth
- Medicaid CT
- Medicaid ME
- Medicaid NH
- Medicaid NY
- Medicaid RI
- Medicaid VT
- Medicare
- Medicare ACO
- Multiplan
- Railroad Medicare
- Senior Whole Health
- TriCare
- Tufts Health Plan
- United Health Care
- Wellpoint
- WellSense
- WellSense NH
Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.
Research
Research within the Pediatric Endocrine-Neuroendocrine-Sports Endocrine Lab aims to further knowledge about endocrine, metabolic, bone, neurocognitive and neuropsychiatric outcomes in girls with low-weight eating disorders, athletes, teenagers and young adults undergoing bariatric surgery or receiving obesity pharmacotherapy, children with diabetes and those with autism spectrum disorders.
Ongoing studies include the following:
- The Role of Estrogen in the Neurobiology of Eating Disorders: A Study of Cognitive Flexibility and Reward in Eating Disorders
- Bone Metabolism in Adolescents Undergoing Bariatric Surgery
- Determinants of bone microarchitectural compromise in youth with type 1 diabetes
- Oxytocin as a neuroendocrine therapy for obesity in youth
Learn more about research at the Pediatric Endocrine Program and Diabetes Center.
Pediatric Endocrine-Neuroendocrine-Sports Endocrine Laboratory
Publications
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Selected Original Articles (from over 190)
1. Misra M, Katzman DK, Miller KK, Mendes N, Snelgrove D, Russell M, Goldstein MA, Ebrahimi S, Clauss L, Weigel T, Mickley D, Schoenfeld D, Herzog DB, Klibanski A. Physiologic Estrogen Replacement Increases Bone Density in Adolescent Girls with Anorexia Nervosa. J Bone Miner Res 2011;26:2430-8
2. Ackerman KE, Singhal V, Baskaran C, Slattery M, Campoverde Reyes K, Toth A, Eddy KT, Bouxsein ML, Lee H, Klibanski A, Misra M. Oestrogen Replacement Improves Bone Mineral Density in Oligo-amenorrheic Athletes: A Randomized Clinical Trial. Br J Sports Med 2019;53(4):229-236.
3. Singhal V, Ackerman KE, Bose A, Torre Flores LP, Lee H, Misra M. Impact of Route of Estrogen Administration on Bone Turnover Markers in Oligoamenorrheic Athletes and Its Mediators. J Clin Endocrinol Metab 2019 May 1;104(5):1449-1458.
4. Bredella MA, Singhal V, Karzar NH, Animashaun A, Bose A, Stanford FC, Carmine B, Misra M. Effects of sleeve gastrectomy on bone marrow adipose tissue in adolescents with severe obesity. J Clin Endocrinol Metab 2020 Nov 1;105(11):e3961-70.
Selected Reviews (from ~100 reviews and position statements)
1. Misra M, Pacaud D, Petryk A, Collett-Solberg P, Kappy M. Vitamin D Deficiency in Children and its Management: Review of Current Knowledge and Recommendations. Pediatrics 2008; 122: 398-417.
2. Misra M. Effects of Hypogonadism on Bone Metabolism in Adolescent and Young Adult Women. Nat Rev Endocrinol 2012;8(7):395-404
3. Misra M, Klibanski A. Endocrine Consequences of Anorexia Nervosa. Lancet Diab Endocrinol 2014;2(7):581-92.