CORE Areas of Research

Principle Investigator: Anne Kirchhoff, PhD
Funding Source: National Cancer Institute
Description: The goal of this study is to develop and test a health insurance navigation program for adolescent and young adults undergoing cancer treatment.

Principal Investigator: Giselle Perez, PhD
Funding Source: National Cancer Institute
Description: The goal of this study is to develop and test a health insurance navigation program for adolescent and young adults undergoing cancer treatment.

Principle Investigator: Jamie Jacobs, PhD
Funding source: American Cancer Society Institutional Research Grant (ACS IRG)
Description: This is a two phase study that endeavors to develop a intervention to help young adult survivors and their caregivers manage the challenges of cancer treatment.

Principle Investigator: Areej El-Jawahri, MD
Description:A prospective longitudinal study of 200 patients to assess QOL, physical and psychological symptoms, perceptions of prognosis, and coping strategies among patients newly diagnosed with indolent hematologic malignancies.

Principle Investigator: Jamie Jacobs, PhD
Description: A double-blinded, randomized, controlled, adaptive trial to compare the relative effectiveness of two digital software medical devices (attune and cerena) as interventions for physical and emotional health in adjunctive oncology treatment, in order to determine the respective impact on anxiety and depressive symptoms in stage I-III breast cancer and stage I-III non-small cell lung cancer participants after 10 weeks of use.

Principle Investigator: Areej El-Jawahri, MD
Funding Source: National Palliative Care Research Center
NAVIGATE is a Randomized Study of a Psychological Intervention Mobile Application (app) “DreAMLand” to Promote Coping in Patients with Acute Myeloid Leukemia (AML). This study assesses the feasibility and preliminary efficacy of the DreAMLand app for patients with a new diagnosis of AML, aiming to assess the ability of the app to help patients cope and provide pertinent information about their diagnosis amid their new hospitalization.

Principle Investigator: Elizabeth K. O’Donnell, MD
Funding Source: Kully Family Foundation
Description: MM QOL is a multi-center study that aims to assess changes in quality of life, psychological distress, and prognostic understanding among multiple myeloma patients receiving treatment as well as their caregivers. Previous research has found that multiple myeloma patients have lower health-related quality of life compared to other cancer survivors. This study examines the emotional and physical effects of a multiple myeloma diagnosis and associated therapies among 180 patients and 180 caregivers. The principal investigator for this study is Dr. Elizabeth K. O’Donnell, with Dr. Areej El-Jawahri serving as a sub-investigator at Massachusetts General Hospital. Dr. Omar Nadeem is the site principal investigator at Dana-Farber Cancer Institute.

Principle Investigator(s): Elyse Park, PhD, MPH Jennifer Haas, MD, Nancy Rigotti, MD
Funding Source: National Institutes of Health, R01
Description: Screen ASSIST is a randomized factorial design trial that tests the effectiveness of three evidence-based tobacco treatment modalities (4 vs. 8 counseling sessions, 2 vs. 8 weeks of NRT, and referral/non-referral to a community resource) among current smokers undergoing lung cancer screening. The study will evaluate the reach, adoption and implementation of the trial across 7 lung cancer screening sites within Mass General Brigham Healthcare System. The trial began enrolling patients in April 2019 and aims to accrue 720 patients.

Principle Investigator: Areej El-Jawahri, MD
Description: A cross-sectional study to develop and validate the Prognostic Awareness Impact Scale (PAIS) in Patients with Incurable Cancer.

Principle Investigator: Elyse Park, Ph.D; Jamie Ostroff, Ph.D.
Funding Source: NIH, NCI
Description: The Smoke Free Support Study 2.0, or SSS2, is designed to examine the effectiveness and implementation of a virtually-delivered, evidence-based tobacco treatment, into cancer care for patients in community oncology settings. SSS2 is designed to compare the effectiveness and implementation of an Enhanced Usual Care (EUC; control group) versus a Virtual Intervention Treatment (VIT; intervention group) for tobacco cessation in newly diagnosed cancer patients who smoke. Trial findings will establish the effectiveness and cost of utilizing a virtual strategy to deliver evidence-based tobacco treatment in community oncology settings and provide detailed initial data on implementation processes that will inform subsequent testing of multi-level implementation strategies for broad national dissemination into community cancer care settings.

Principle Investigator: Elyse Park, Ph.D; Nancy Rigotti, MD; Jennifer Haas, MD
Funding Source: NIH / NCI R01
Description: The trial offers tobacco cessation treatment to smokers having a lung cancer screening test. It is designed to help us meet the U.S. Preventive Services Task Force recommendation to offer smoking cessation as part of lung cancer screening. Screen ASSIST will identify current smokers who schedule a lung cancer screening test and offer them participation in a smoking cessation study. All study participants will receive evidence-based cessation treatment at no cost. The goal is to identify the most effective combination of (1) tobacco cessation counseling (4 vs. 8 sessions); (2) nicotine replacement (2 vs. 8 weeks); and referral to a community-based resource to address social stresses that make quitting difficult (referral vs. no referral). Smoking status (primary outcome) will be measured at 6-month follow-up.

Principle Investigator: Elyse Park, Ph.D; Giselle Perez Lougee Ph.D.
Funding Source: American Cancer Society
Description: Dr. Park and her colleagues published findings in the Journal of Clinical Oncology demonstrating that CCSS survivors, compared to siblings, were significantly more likely to be uninsured and to have difficulties obtaining health insurance. Given the current insurance landscape and the additional insurance burden that childhood cancer survivors face, the present study seeks to develop and pilot a health insurance navigation program targeted at feasibility and acceptability with survivors and improving health insurance literacy and ameliorating financial distress related to medical costs. The proposed health insurance navigation will involve 4 navigator-led health insurance navigation sessions. The study investigators propose that, compared to the control arm (who will receive a health insurance information guide, but will not receive the navigation intervention), participants in the intervention arm will have improved health insurance literacy and decreased financial distress related to medical costs.

Principle Investigator: Elyse Park, Ph.D; Giselle Perez Lougee Ph.D.
Description: This trial aims to assess the feasibility and acceptability of colorectal survivors approached and engaged in HINT and aims to assess the preliminary efficacy of HINT to improve 1) health insurance literacy and 2) financial burden related to medical cost concerns colorectal survivors. The study investigators propose that, compared to the control arm (who will receive a health insurance information guide, but will not receive the navigation intervention), participants in the HINT intervention arm will have improved health insurance literacy and decreased financial distress related to medical costs.

Principle Investigator: Elyse Park, Ph.D
Funding Source: U.S. Health Resources and Services Administration (HRSA)
Description: The prolonged strain of the COVID-19 pandemic has taken an emotional toll on healthcare workers who continuously face resource-constraints, perpetual uncertainty about the overall impact and duration of the pandemic, changes in clinical knowledge and guidelines, and the high rates of patient mortality and morbidity. The goals of this project are to (1) identify and implement evidence-based informed programs that promote resilience, wellness, and mental health among the health center workforce serving in rural and medically underserved areas of Massachusetts and (2) to enhance organizational cultures at these health centers to move towards a sustainable model for enhancing employee mental health and wellness.

Principal Investigator: Tejaswini More Dhawale, MD
Description: This study examines patients’ and their caregivers’ experiences with talking to their oncologist about the risks and benefits of CAR T-cell therapy and explore what patients and their caregivers understand from these conversations and what they feel is missing from these discussions.

Principal Investigator: Areej El-Jawahri, MD
Description: A multi-site trial to assess the effectiveness of a home-based ACP video for optimizing EOL care for patients with life-limiting illness.

Principal Investigator: Laura Petrillo, MD
Funding Source: N/A
Description: IO is a mixed methods study to elucidate how patients with metastatic melanoma or non-small cell lung cancer (NSCLC), their caregivers, and oncology clinicians currently communicate about the risks, benefits, and goals of treatment with immunotherapy, and understand what makes such communication challenging from the perspective of patients, caregivers, and oncology clinicians. Immunotherapy, specifically a class of drugs called immune checkpoint inhibitors, has demonstrated impressive survival benefits in both of these diseases for a minority of patients who receive them. However, the range of possible outcomes with immunotherapy makes understanding the goal of treatment difficult for patients, especially given the potential for indefinite, long-term responses. This study will inform the development of a supportive care intervention tailored to patients with metastatic melanoma or NSCLC and their caregivers.

Principal Investigator: Nneka N. Ufere, MD
Description: A study assessing the prognostic capabilities of the Surprise Question in inpatients with end-stage liver disease.

Principal Investigator: Areej El-Jawahri, MD
Funding Source: Internal Funding
Description: TRANSITIONS is a 45-participant qualitative study that addresses a gap in the literature about discharge decision-making and posthospital transitions of care among older adults with advanced cancer. The goal of the study is to identify components of the discharge decision-making process for patients hospitalized with advanced cancer in order to inform future interventions to improve their quality of end-of-life care and reduce burdensome transitions of care at the end-of-life. We aim to 1) explore clinicians’ perceptions of the factors relevant to making discharge decisions for hospitalized patients with advanced cancer, 2) explore patients’ and caregivers’ perceptions of the factors relevant to making discharge decisions; and 3) assess patients’ and caregivers’ perceptions of post-discharge care after hospitalization.

Principle Investigator: Laura Petrillo, MD
Funding Source: Conquer Cancer, The ASCO Foundation
Description: UPLIFT is a randomized controlled trial of an educational intervention to improve patient and caregiver understanding of what to expect from treatment with an immune checkpoint inhibitor for lung cancer or melanoma. This study assesses the feasibility and preliminary efficacy of the educational intervention in improving patient and caregiver knowledge, enhancing patient-clinician communication, and reducing anxiety.

Principle Investigator: Tejaswini More Dhawale, MD
Description: A study to describe how serious illness conversations and advanced care planning (SIC/ACP) occurred during digital health encounters for patients with metastatic lung and gastrointestinal cancers during the COVID-19 pandemic in Massachusetts.

Principal Investigator: Kelly Irwin, MD
Funding Source: National Cancer Institute
Description: The BRIDGE Trial: Proactive Psychiatry Consultation and Case Management for Patients with Cancer is a randomized controlled trial assessing the impact of proactive psychiatry consultation and person-centered collaborative case management for patients who have both a serious mental illness and a recent cancer diagnosis. The trial examines the impact of proactive psychiatric consultations and social work consultations on cancer care, as well as on patient and caregiver-reported outcomes. BRIDGE also aims to determine and address barriers and facilitators to implementing and disseminating a proactive psychiatry and social work intervention. To learn more, please email the study contact, Maura Barry.

Clinical Trials page

Principle Investigator: Jamie Jacobs, PhD
Description: Develop and refine a brief, individualized, culturally-competent nurse-led intervention using qualitative data from semi-structured interviews with breast cancer survivors to promote hormonal therapy medication initiation.

Principal Investigator: Areej El-Jawahri, MD
Funding Source: Leukemia and Lymphoma Society
Description: CAR T PRO is a Longitudinal Study of Quality of Life and Psychological Distress in Patients Receiving CAR T Therapy and Their Caregivers. This study examines the experience of CAR T therapy on patients along with their prognostic understanding with receiving their CAR T therapy. Since this is a new type of cancer therapy, our goal is to better understand this experience so that we may better assist them and their caregivers through this process in the future. This study also involves a neurocognitive assessment to better understand the potential cognitive effects of CAR T over the course of their treatment. We have an accrual goal of 100 patients.

Principal Investigator: Areej El-Jawahri, MD
Funding Source: Leukemia and Lymphoma Society
Description: CREATE is a Randomized Controlled Trial of an Educational Video Tool for Patients Receiving CAR T-Cell Therapy. This study is assessing the feasibility, efficacy, and acceptability of this educational video tool on these patients, and we are attempting to determine its impact on preferences and knowledge of CAR T Therapy. We have an accrual goal of 60 patients.

Principal Investigator: Areej El-Jawahri, MD
Funding Source: Internal Funding
Description: ENVISION 2.0 is a 600-patient cross-sectional study that seeks to refine and further develop an instrument to assess the multi-dimensional aspects of prognostic awareness. Our group has previously developed the Perception of Treatment and Prognosis Questionnaire (PTPQ) to assess patients’ overall perception of their prognosis and treatment goals. Studies utilizing the PTPQ have shown that patients with cancer have substantial misperceptions about their prognosis and overall goals of their treatment. However, we have noted important limitations of the PTPQ in assessing important domains of prognostic awareness including the cognitive acknowledgement of having a life limiting illness, how patients cope with their prognostic awareness, and their distress from prognostic uncertainty. The goal of this study is to conduct further scale development and evaluation of the PTPQ by testing its psychometric properties.

Principal Investigator: Tejaswini More Dhawale, MD
Description: A sequential mixed methods study that describe unmet palliative care needs in patients with newly diagnosed aggressive hematologic malignancies and to explore patient attitudes towards early palliative care integration with standard oncology care for hematologic malignancies.

Principal Investigator: Nneka N. Ufere, MD
Description: A single arm pilot study of early integrated palliative care in patients with end-stage liver disease.

Principal Investigator: Areej El-Jawahri, MD
Description: A pilot study to assess the feasibility of a hospital-at-home EOL care model for patients with hematologic malignancies.

Principal Investigator: Nneka N. Ufere, MD
Funding Source: GI Innovations Award
Description: PALCare is a prospective longitudinal survey study of patients with end-stage liver disease (ESLD) and their caregivers to generate a comprehensive assessment of their experiences. This study aims to assess the quality of life, symptom burden, and perception of illness and prognosis for patients with ESLD as well as assessing the quality of care received by these patients at end of life. Additionally, the study aims to assess the burden and distress for caregivers of patients with end-stage liver disease. The results of this project will be used to develop palliative care interventions that address the specific needs of ESLD patients and their caregivers over the course of their illness trajectory both pre- and post-transplant and at end of life."

Principal Investigator: Areej El-Jawahri, MD
Funding Source: Internal Funding
Description: PROTECT is a multisite, randomized control trial of inpatient palliative care integrated with transplant care versus transplant care alone in patients with hematologic malignancies undergoing hematopoietic stem cell transplantation. The primary goal of this study is to test the efficacy of inpatient palliative care integrated with transplant care for improving patient-and caregiver-reported outcomes. Additionally, we will assess participants’ long-term quality of life and psychological outcomes. There are three sites participating in the study – MGH, Duke Cancer Center, and Fred Hutchinson Cancer Center.

Principal Investigators: Jennifer Temel, MD
Description: A cluster randomized comparative effectiveness trial of primary palliative care (PC) versus specialty PC in 1150 patients with acute myeloid leukemia (AML) and their caregivers.

Principal Investigators: Jennifer Temel, MD and Joseph Greer, PhD
Funding Source: Patient-Centered Outcomes Research Institute
Description: REACH PC is a multisite study of 1250 patients that compares the effectiveness of early integrated palliative care versus in-person palliative care for patients with advanced lung cancer. Early and longitudinal involvement of palliative care in the outpatient management of patients with advanced cancer has been shown to improve patient-reported and end-of-life care outcomes. Many cancer care settings, however, have insufficient outpatient palliative care services and patients who receive care in remote, resource-poor, and rural settings may have no access to these services. By using secure video-conferencing technology, it is possible to overcome these barriers and increase patients' access to palliative care services in a patient-centered manner. The primary goal of this study is to determine if telehealth palliative care is just as effective as in-person palliative care for improving quality of life, mood, symptoms, and satisfaction with care for patients with advanced lung cancer and their caregivers.

Principal Investigator: Areej El-Jawahri, MD
Funding Source: Massachusetts General Hospital Executive Committee on Research
Description: SPRINT is a multi-site randomized controlled trial of collaborative palliative and leukemia care versus standard leukemia care alone in patients with AML and high-risk MDS receiving non-intensive chemotherapy. The intervention entails longitudinal inpatient and outpatient palliative care visits for this population focusing on symptom management, illness understanding, treatment decision-making, EOL care planning, and patients’ coping. This research will benefit the field of oncology by demonstrating improvements in the quality of care and resource utilization through timely integration of palliative care for patients with AML and high-risk MDS receiving palliative chemotherapy. 

Principal Investigator: Jennifer Temel, MD
Funding Source: National Institutes of Health (R01 CA215188)
Description: STEP is a randomized controlled trial designed to determine whether a stepped palliative care model is non-inferior to an early integrated palliative care model for patients with advanced lung cancer. In the stepped care group, patients meet with a palliative care clinician only at clinically relevant times, unless their quality of life worsens a great deal and then they “step up” to monthly visits. Patients assigned to the early integrated palliative care intervention maintain monthly visits with a palliative care clinician. The primary outcome is patient-reported quality of life, and secondary outcomes include quality of end of life care, palliative care resource utilization, and cost-effectiveness.

Principal Investigator: Areej El-Jawahri, MD
Description: Prospective cohort study assessing the quality of life trajectory, treatment toxicity, and healthcare utilization of older adults undergoing treatment for aggressive non-Hodgkin lymphomas.

Principal Investigator: Ryan Nipp, MD, MPH
Funding Source: National Institutes of Health
Description: Cancer disproportionately affects older adults, and older adults with advanced cancer often possess a distinct set of medical and psychosocial issues that makes caring for the geriatric oncology population challenging. Due to the existence of a critical knowledge gap regarding how to best deliver comprehensive cancer care targeting the unique geriatric and palliative care needs of these individuals, this study proposes the creation of a geriatric oncology collaborative care intervention to improve supportive care outcomes for older adults with advanced cancer. The intervention will entail visits with a specially trained clinician in the cancer center to address patients' unique needs, who will meet regularly with a supervising team of geriatric, palliative care, social work, and pharmacy clinicians for feedback and iterative reevaluation of the care plan.

Principal Investigator: Giselle Perez, PhD
Funding Source: National Cancer Institute
Description: Bounce Back is a pilot randomized control trial examining the preliminary feasibility and acceptability of a virtual group stress management and resiliency program for adolescent and young adult (AYA) cancer survivors. The program consists of eight 90-minute sessions led by an experienced MGH clinician during which participants will learn tailored stress management skills and discuss survivor-specific topics (i.e. exercise, healthy eating). Survivors will be eligible if they 1) are between the ages of 16-29, 2) were diagnosed with cancer between the ages of 14-29, and 3) completed cancer treatment within the last 5 years. 

Interested participants can sign up for the study and learn more information here

Principle Investigator: Elizabeth K. O’Donnell, MD
Funding Source: Kully Family Foundation
Description: Fasting Study is a pilot study evaluating the feasibility of a 12-week prolonged nightly fasting intervention in breast cancer survivors. Effects on body size, blood biomarkers, quality of life, emotional regulation, fatigue, and levels of physical activity will be assessed. Drs. Jeffrey Peppercorn and Amy Comander serve as the sub-investigators at Massachusetts General Hospital.

Principle Investigator: Elizabeth K. O’Donnell, MD
Funding Source: Haymakers for Hope
Description: Haymakers for Hope is a pilot study examining the feasibility of a 16-week boxing-based fitness program for cancer survivors sponsored by Haymakers for Hope (H4H), a non-profit organization that raises money for cancer through charity boxing events. Participants attend weekly supervised sessions comprising strength, flexibility, and balance exercises. This intervention aims to improve cardiopulmonary fitness, muscle strength, body composition, quality of life, fatigue, and mood. 

Principle Investigator(s): Elyse Park, PhD, MPH
Funding Source: American Cancer Society
Description: The HINT (Health Insurance Navigation Tools) study seeks to develop a health insurance navigation program for survivors of childhood cancer. The present study proposes a health insurance navigation program to assist childhood survivors in understanding and utilizing their health insurance in a positive manner. The proposed navigation intervention will include 4 weekly videoconferencing-based sessions with a health insurance navigator on the following domains: 1. Learning Abut Survivorship Healthcare Needs; 2. Learning About Your Plan in Relation to Policy; 3. Navigating One's Own Plan and Overcoming Obstacles; 4. Managing Care Costs. This study aims to develop a psychoeducational health insurance navigation program (HINP), to conduct a videoconferencing-based pilot randomized trial of the HINP (n= approximately 80), and to refine the HINP program for future use. 

Principle Investigator(s): Elyse Park, PhD, MPH
Description: This trial aims to assess the feasibility and acceptability of colorectal survivors approached and engaged in HINT and aims to assess the preliminary efficacy of HINT to improve 1) health insurance literacy and 2) financial burden related to medical cost concerns for colorectal survivors.

HINT-C Clinical Trial

Principal Investigator: Areej El-Jawahri, MD
Description: Multidisciplinary Intervention to Promote Medical Adherence and Coping in Patients with Moderate to Severe Chronic Graft-versus-Host disease.

Principal Investigator: Laura Petrillo, MD
Description: An open pilot study of a palliative care intervention for patients with metastatic oncogene-driven NSCLC.

Principal Investigator: Areej El-Jawahri, MD
Funding Source: American Cancer Society, Research Scholar Grant
Description: SPARK is a randomized trial assessing the effectiveness of multimodal sexual health consults for hematopoietic stem cell transplant (HCT) survivors experiencing disruption in sexual health or intimacy following transplant. Despite the prevalence of sexual dysfunction in HCT survivors, interventions to improve sexual function are lacking, creating a critical need for comprehensive intervention. The study aims to evaluate the efficacy of clinician consult in improving patient-reported sexual function. We additionally aim to assess the impact of the intervention on patient-reported quality of life and psychological outcomes. We hope data from this project will lay the foundation for a future multi-site trial to enhance sexual function and survivorship care for HCT survivors. 

Principal Investigator: Areej El-Jawahri, MD
Funding Source: National Institute of Nursing Research
Description: SHIFT is a randomized trial assessing the effectiveness of an intervention aiming to improve sexual dysfunction in hematopoietic stem cell transplant (HCT) survivors. Despite the high prevalence of sexual dysfunction in HCT survivors, there are currently no interventions to address the disruptions in sexual health affecting this population. Additionally, to our knowledge no studies exist regarding the efficacy of a mobile app to specifically address sexual dysfunction. The goal of this study is to develop, refine, and test a self-administered, mobile sexual dysfunction intervention application (app). In addition to assessing the feasibility of the intervention in addressing sexual dysfunction in HCT survivors, we additionally plan to determine the preliminary efficacy of the intervention in improving patient-reported sexual function, quality of life, and psychological outcomes.

Principle Investigator: Elyse Park, PhD, MPH
Funding Source: National Institutes of Health, Sponsor: ECOG-ACRIN Cancer Research Group, Collaborator: National Cancer Institute (NCI)
Description: The Smoke Free Support Study 2.0 examines the effectiveness and implementation of a virtually delivered evidence-based tobacco treatment at community-based cancer centers (NCORP). This phase II trial studies how well smoking cessation treatment plans work in tobacco-dependent cancer patients in community oncology practices when delivered virtually as a part of their cancer care. Providing virtual information and counseling sessions may help cancer patients quit smoking. The study aims include assessing treatment effectiveness by comparing participants assigned to Enhanced Usual Care (EUC) and Virtual Tobacco Treatment (VIT) study arms abstinence post enrollment, assessing the potential effect of moderators (e.g. sociodemographic, medical and smoking history, cancer variables) on treatment effectiveness between the two arms, and assessing the processes of implementation and dissemination (acceptability, adoption, appropriateness, treatment fidelity, cost effectiveness, penetration/reach, and sustainability) of delivering these interventions at community oncology sites.

Principle Investigator: Lara Traeger, PhD
Funding Source: Internal Funding and Support from the Phyllis & Jerome Lyle Rappaport Foundation
Description: The Transitions Project is a feasibility randomized clinical trial testing whether the program is feasible and acceptable to patients. As patients with thoracic cancers complete treatment with curative intent, they may face heightened uncertainty about the future or other stressors during their shift to follow-up care. We have developed a supportive care program to help patients learn and practice specific skills for maintaining quality of life during this unique transition. We also will explore how the program may help patients improve different aspects of their quality of life. Findings from this study will help us to enhance the standard of care for patients with thoracic cancers.

Principle Investigator(s): Joseph Greer, PhD and Jennifer Temel, MD
Funding Source: National Institutes of Health (R01 NR016694)
Description: BREEZE is a randomized controlled trial designed to test the efficacy of a two-session behavioral intervention for improving self-reported dyspnea in patients with advanced lung cancer. This nurse-delivered intervention aims to improve patients’ dyspnea, quality of life, psychological distress, and activity level through psychoeducation, relaxation training, and behavioral symptom management techniques. The principal investigators for this study are Drs. Joseph Greer and Jennifer Temel at Massachusetts General Hospital, with Dr. Mary Cooley serving as the site principal investigator at Dana-Farber Cancer Institute.

Principle Investigator: Jennifer Temel, MD
Description: A pilot study to assess the feasibility and acceptability of the CONTINUUM intervention in patients with advanced cancer upon hospital discharge.

Principle Investigator: Jeffrey Peppercorn, MD, MPH
Funding Source: Outcomes4Me, Inc.
Description: FIONA is a single-arm pilot study of a breast cancer management smartphone app that is intended to assist patients in understanding their diagnosis and treatment options and managing their care, through symptom tracking and disease-directed information and resources. The purpose of this study is to understand how the Outcomes4Me app could be used to provide personalized support and care management for patients. This study aims to assess the feasibility of introducing use of the Outcomes4Me app within the standard care experience of breast cancer patients; evaluate the usability, satisfaction, and engagement of the app among patients.

Principal Investigator: Nneka N. Ufere, MD
Description: A cross sectional qualitative study assessing financial burden, work productivity, and quality of life in liver transplant recipients.

Principle Investigator: Jamie Jacobs, PhD
Funding Source: National Cancer Institute
Description: STRIDE is a randomized control trial examining the feasibility and acceptability of a small-group, videoconference intervention to optimize AET adherence, improve symptom management, and reduce distress for women taking adjuvant endocrine therapy (AET) after treatment for early stage, hormone receptor positive breast cancer. The primary objective of the current randomized controlled trial is to examine the feasibility and acceptability of the program. The secondary objectives are to examine changes in medication adherence, symptom distress, and overall satisfaction with AET. Findings from this study may inform survivorship care and inform next steps for improving clinical and psychological outcomes for patients taking AET. 

Principal Investigator: Ryan Nipp, MD, MPH
Funding Source: Stand Up to Cancer; Dana Farber/Harvard Cancer Center
Description: Patients receiving preoperative FOLFIRINOX often experience numerous symptoms and side effects. Frequently, these patients require hospital admissions to help address uncontrolled symptoms related to their cancer and treatment. Medically Home interventions, which entail providing medical care to patients in their homes, may provide a solution. Additionally, previous research has demonstrated that symptom monitoring interventions can enhance patient outcomes. Thus, the goal of this study is to evaluate the feasibility and acceptability of an intervention, which we call "Supportive Oncology Care at Home," that entails both remote patient monitoring (e.g. symptoms, vital signs, and body weight) and a Medically Home care model (e.g. algorithms for phone calls and visits to patients' homes to address and manage any concerning issues identified). To accomplish this, we are conducting a single-arm pilot study in patients with pancreatic cancer receiving neoadjuvant FOLFIRINOX.

Principal Investigator: Ryan Nipp, MD, MPH
Description: Randomized control trial to determine the effect of the Supportive Oncology Care at Home intervention on admission to the hospital or ED in patients receiving definitive (curative) treatment. Intervention arm involves remote monitoring of patient vital signs, scheduled IV hydration, and acute symptom management at home.

Principal Investigator: Ryan Nipp, MD, MPH
Description: Single-arm pilot study in recently hospitalized patients with advanced cancer to assess the feasibility and acceptability of Supportive Oncology Care at Home involving remote monitoring of patient vital signs, scheduled IV hydration, and acute symptom management.

Principle Investigator(s): Joseph Greer, PhD
Description: A randomized control trial of a supportive care mobile application to improve symptoms, coping, and quality of life in patients with Advanced Non-Small Cell Lung Cancer (NSCLC).