Potential cholera vaccine target discovered
Findings from a team led by investigators at Massachusetts General Hospital may help scientists develop a more effective vaccine for cholera.
Edward T. Ryan, M.D. is the Director of Global Infectious Diseases, Massachusetts General Hospital, Boston, MA, Professor of Medicine, Harvard Medical School, and Professor of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health. Dr. Ryan received his Bachelor's degree in Biochemical Sciences from Princeton University, and a Doctorate in Medicine from Harvard University. He performed medical residency and fellowship training in infectious diseases at the Massachusetts General Hospital. Dr. Ryan received additional training in tropical medicine and infectious diseases at the London School of Hygiene & Tropical Medicine, was a Fellow in Human Rights & Medicine, Columbia University, and was an International Fellow, International Centre for Diarrhoeal Disease Research (ICDDR, B), Dhaka, Bangladesh.
Dr. Ryan has served on expert and advisory committees for the Institute of Medicine-National Academy of Sciences, U.S. Centers for Disease Control & Prevention, chaired the Clinical Research and Field Studies of Infectious Diseases Study section of the US NIH from 2006-2008, currently chairs the Standards and Treatment Guidelines Committee of the American Society of Tropical Medicine & Hygiene (ASTMH), and served as ASTMH President from 2009-2010. Dr. Ryan has been elected to Fellowship of the American College of Physicians, the Infectious Diseases Society of America, the American Society of Tropical Medicine and Hygiene, and the American Academy of Microbiology. Dr Ryan has published over 350 peer-reviewed journal articles and book chapters on global infectious diseases, enteric infections, vaccines, and tropical medicine. Dr. Ryan is a Senior Editor of Hunter's Tropical Medicine, and a Medical Editor of the Centers for Disease Control and Prevention Yellow Book.
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Dr. Ryan's research focuses on clinical studies of illnesses associated with residing in, immigrating from, or traveling through resource-limited settings. His research is funded by the U.S. National Institute of Allergy and Infectious Diseases (NIAID) and the U.S. Centers for Disease Control & Prevention (CDC). Dr. Ryan is the principal investigator on research projects focusing on enteric vaccine and diagnostic development and host-pathogen studies on V. cholerae (the cause of cholera), Salmonella enterica serovar Typhi (the cause of typhoid fever), and Shigella spp. (a cause of bacillary dysentery). Particular areas of focus include the application of high throughput genomic, proteomic, immunoproteomic, and web-based platform technologies to these illnesses. Dr. Ryan is also the Director of Global TravEpiNet (GTEN), a CDC-sponsored national consortium focusing on global infectious diseases and evaluating vaccination strategies and use among global international travelers, as well as the acquisition of highly drug resistant bacteria during travel. He is the principal investigator and program director for a Fogarty International Center, National Institutes of Health (NIH)-sponsored Training Program in Vaccine Development and Public Health between Harvard-MGH and the ICDDR,B in Dhaka, Bangladesh. Dr. Ryan teaches tropical medicine and infectious diseases in the core curricula at Harvard Medical School, Harvard School of Public Health, and Harvard College, teaches students, residents and fellows at the MGH, and teaches in a number of post-graduate courses at Harvard Medical School and internationally.
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Findings from a team led by investigators at Massachusetts General Hospital may help scientists develop a more effective vaccine for cholera.
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