Common cause of heart attacks in younger adults linked to gene variants
Mutations in genes that direct the production of fibrillar collagens, essential components of blood vessel walls, appear to predispose individuals to SCAD.
Dr. Pradeep Natarajan is the Director of Preventive Cardiology and the Paul and Phyllis Fireman Endowed Chair in Vascular Medicine at Massachusetts General Hospital, Associate Professor of Medicine at Harvard Medical School, Associate Member of the Broad Institute of Harvard and MIT.
He received his BA in molecular biology with Honors and Phi Beta Kappa in 2004 from the University of California, Berkeley. He received his MD with Alpha Omega Alpha in 2008 from the University of California, San Francisco. He received his MMSc in biomedical informatics in 2015 from Harvard Medical School. Dr. Natarajan completed his internship and residency in internal medicine at the Brigham and Women’s Hospital in 2011. He completed his clinical and research fellowship in cardiovascular medicine at the Massachusetts General Hospital in 2015.
Dr. Natarajan uses germline and somatic genetic variation to uncover new biology and enable enhanced clinical care for cardiovascular disease. He leads several consortia to use genetic epidemiology, large-scale sequencing studies, genotype-driven human investigation, and genetic testing implementation. Among his scientific contributions, he has pioneered ‘human knockout’ discovery and investigation to prioritize therapeutic targets, monogenic and polygenic characterization of heritable traits through whole genome sequencing, and the novel concept of somatic mutations contributing to cardiovascular disease.
In tandem his research efforts, Dr. Natarajan oversees clinical and training programs on the prevention of cardiometabolic diseases leading the MGH Cardiovascular Disease Prevention Center.
To learn more about Dr. Natarajan's research, please visit http://natarajanlab.mgh.harvard.edu.
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Mass General Heart Center
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http://natarajanlab.mgh.harvard.edu
https://www.ncbi.nlm.nih.gov/myncbi/pradeep.natarajan.1/bibliography/public/
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Mutations in genes that direct the production of fibrillar collagens, essential components of blood vessel walls, appear to predispose individuals to SCAD.
Una nueva investigación dirigida por investigadores de Mass General revela que las mujeres con menopausia prematura a menudo presentan ciertos cambios en las células sanguíneas que elevan el riesgo de desarrollar enfermedad arterial coronaria.
A new study reveals reveals women with premature menopause often exhibit certain blood cell changes that elevate their risk of developing coronary artery disease.
新研究表明,过早绝经的女性往往会出现某些血细胞变化,从而增加她们罹患心血管疾病的风险。
在本次问答中,医学博士及心脏病学研究员 Jay Khambhati、注册护士及临床研究护士 Tinamarie Desmarais、注册护士、理科硕士、美国心血管和肺康复协会 (AACVPR)成员及联合主席Kathleen C. Traynor,以及医学博士、医学硕士、心血管疾病预防中心联合主席 Pradeep Natarajan 将会介绍存在心血管疾病风险的患者应如何在新型冠状病毒大流行期间保持健康。
Elevated levels of a little-known lipoprotein in the blood that may put people at high risk of cardiovascular disease can be as accurately detected by genetic testing as by conventional laboratory measurement.