David Sykes, MD, PhD
About David Sykes, MD, PhD
David completed his undergraduate training in Biochemistry at the University of Alberta in Edmonton, Canada. He entered the Medical Scientist Training Program (M.D., Ph.D.) at the University of California San Diego and carried out his Ph.D. research with Dr. Mark Kamps where he became interested in the problems that arise during white blood cell development.
David did his internship and residency at the Massachusetts General Hospital as well as a year as a Chief Medical Resident in the Department of Internal Medicine. He was a Hematology and Oncology fellow in the combined Dana-Farber Cancer Institute, MGH Cancer Center fellowship program.
David joined the MGH Cancer Center as an attending in benign hematology. He splits his time between the laboratory (80% research) and clinic (20% direct patient care).
David has a special interest in rare hematologic conditions. In 2011 he defined a new syndrome - the TEMPI syndrome - which affects approximately 20 patients worldwide (https://www.nejm.org/doi/full/10.1056/NEJMc1106670).
David completed his post-doctoral research training in the laboratory of Dr. David Scadden, working to identify new therapies for patients with acute myeloid leukemia.
David transitioned to his own lab as an assistant professor in 2017 (http://sykeslab.com/).
He continues to see patients in clinic on Fridays and see patients in the hospital on the inpatient hematology consult service.
Clinical Interests:
- Benign hematology
- Myeloproliferative diseases
- Thrombosis and hemostasis
Treats:
- Adult
Languages:
- French
Locations
Mass General Cancer Center: Hematology Oncology
55 Fruit St.
Boston, MA 02114
Phone: 617-724-4000
Fax: 617-724-6801
Medical Education
- MD, UCSD
- Residency, Massachusetts General Hospital
- Fellowship, Dana Farber Cancer Institute
Accepted Insurance Plans
- Aetna
- Beech Street
- Blue Cross Blue Shield
- Blue Cross Blue Shield Medicare
- Cigna
- Commonwealth Care Alliance
- Coventry
- Fallon Health
- Harvard Pilgrim Health Care
- Humana
- Maine Community Health Options
- Mass General Brigham Health Plan
- MassHealth
- Medicaid ME
- Medicaid NH
- Medicaid VT
- Medicare
- Medicare ACO
- Multiplan
- Senior Whole Health
- TriCare
- Tufts Health Plan
- United Health Care
- Wellpoint
- WellSense
- WellSense NH
Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.
Research
The Sykes Lab is interested in a variety of topics, all centered around white blood cell development and how this development can be corrupted in the setting of infection, cancer or inherited disorders.
1. Acute myeloid leukemia represents a defect in white blood cell development where the white blood cells are frozen at an immature (called undifferentiated) stage of maturation. We are working to develop 'differentiation therapy' for patients with AML -- therapy designed to trick the immature leukemia cells into resuming their normal process of maturation.
2. The Barth Syndrome is a rare inherited X-linked disorder in which children do not have the enzyme tafazzin, and therefore develop both cardiomyopathy and neutropenia. We are working to understand the mechanism that links the lack of tafazzin activity to the development of neutropenia.
3. Metastatic prostate cancer almost always targets the bone and bone marrow. We are working to understand this specific relationship between prostate cancer and why it preferentially targets the bone marrow and how to stimulate the immune cells to eradicate the tumor cells.
Visit went well, Dr. made a plan for future care
Dr. David Sykes is one the most knowledgeable and available doctors I have ever had.
Dr David Sykes is incredible hemotology MD ! - Has a great way of speaking to you, very intense and likeable..almost magical - too soon to know therapy recommended - blood tests still going on - - Dr [redacted] his assistant also terrific ! Hope they can make me better !
He was professional, listened, was easy to understand, and genuine.
Dr. Sykes was very patient and explained things in easy to understand terminology. He answered all of my questions and put my mind at ease. I did not feel rushed in any way and would highly recommend him.
Dr. Sykes was so easy to talk to. He really cared about me and wanted to know all about me. He did an excellent job of explaining my blood test results. Excellent teacher. Compassionate.
Dr sykes was excellent. He explained everything in a manor which I understood. It was probably one of the best experiences I ever had in visiting a dr. Although every everyone at mass general always does a fantastic job. Thank you for that. Dr Sykes followed up with me immediately after my blood work was completed. He told me exactly what I had to ... Read More
Very professional and caring for me as a patient!
My experience with Dr. Sykes was a great experience. He was very informative and the staff was wonderful. I was very happy.
Excellent care