Many patients with severe COVID-19 recover consciousness, but recovery can take days or even weeks
Researchers find that low blood oxygen levels are linked with a longer time to regain consciousness.
Using fMRI, EEG, neurophysiologic recordings, microdialysis methods, and mathematical modeling, my laboratory collaborates with investigators from MGH, Harvard, MIT, and Boston University to use a systems neuroscience approach in studying how the state of general anesthesia is induced and maintained. The long-term goal of this research is to establish a neurophysiological definition of anesthesia; safer, site-specific anesthetic drugs; and to develop better neurophysiologically-based methods for measuring depth of anesthesia.
Recent technological and experimental advances in the capabilities to record signals from neural systems have led to an unprecedented increase in the types and volume of data collected in neuroscience experiments and hence, in the need for appropriate techniques to analyze them. Therefore, using combinations of likelihood, Bayesian, state space, time-series and point process approaches, a primary focus of the research in my laboratory is the development of statistical methods and signal-processing algorithms for neuroscience data analysis.
We have used our methods to:
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Researchers find that low blood oxygen levels are linked with a longer time to regain consciousness.
Although treatment for those infected with SARS-CoV-2 has improved, concerns about neurological complications from COVID-19 continue to proliferate. Neurological symptoms such as loss of smell, confusion and headaches have been reported over the course of the pandemic.
Aunque los investigadores están empezando a comprender los síntomas que subyacen a las secuelas neurológicas de la infección por el SARS-CoV-2, los efectos directos e indirectos del SARS-CoV-2 en el cerebro siguen sin estar claros.