About Paul Huang, MD, PhD

Clinical Interests:

Treats:

Languages:

Locations

Mass General Concierge Medicine
50 Staniford St.
10th Floor
Boston, MA 02114
Phone: 617-643-2132

Medical Education

  • PhD, Harvard Medical School
  • Residency, Massachusetts General Hospital

American Board Certifications

  • Cardiovascular Disease, American Board of Internal Medicine
  • Internal Medicine, American Board of Internal Medicine

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.


Research

Dr. Paul Huang's research focuses on the roles of nitric oxide (NO) in cardiovascular disease and metabolism, using techniques ranging from molecular biology, physiology, and genetically altered mouse models, to human translational studies and induced pluripotent stem (iPS) cell approaches. His research laboratory is studying how the metabolic abnormalities seen in diabetes and obesity affect vascular function and predispose to cardiovascular disease, including stroke and heart attack. His most recent work shows the importance of eNOS phosphorylation to atherosclerosis, stroke, and insulin resistance. Clinically, Dr. Huang leads the Cardiac Metabolic Syndrome Program in the MGH Cardiovascular Disease Prevention Center. He is PI of the translational research CAMP MGH Study (MGH Cardiology and Metabolic Patient Cohort), the first and largest cohort derived from MGH Heart Center patients with detailed phenotyping, genotyping, and physiologic characterization of glucose tolerance and vascular dysfunction. As a member of the Harvard Stem Cell Institute, Dr. Huang is deriving iPS cells from subjects carrying genetic variants that increase risk for type 2 diabetes to test beta cell function, and from subjects with chemotherapy induced cardiomyopathy to test cardiac myocytes contractility.

Publications

  • Select Publications:

    •  Huang PL. Creating a comprehensive definition for metabolic syndrome. Dis Models Mech 2009; 2: 231-7.
    •  Huang PL. eNOS, metabolic syndrome, and cardiovascular disease. Trends Endocrinol Metab 2009; 20: 295-302.
    • Schleicher M, Yu J, Murata T, Derakhshan B, Atochin D, Qian L, Kashiwagi S, Di Lorenzo AD, Harrison KD, Huang PL* and Sessa WC*. The Akt1-eNOS axis illustrates the specificity of kinase/substrate relationships in vivo. Science Signaling 2009, 2: ra41.
    • Rask-Madsen C, Li, Q, Freund B, Feather D, Abramov R, Wu IH, Chen K, Yamamoto-Hiraoka J, Goldenbogen J, Sotiropoulos KB, Clermont A, Geraldes P, Dal'Osso C, Wagers AJ, Huang PL, Rekhter M, Scalia R, Kahn CR and King GL. Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. Cell Metabolism 2010; 11: 379-89.
    • Huang PL. HDAC5: Going with the flow. Blood 2010; 115: 2728-9.
    • Atochin DN, Yuzawa I, Li Q, Rauwerdkin K, Malhotra R, Brouckaert P, Ayata C, Moskowitz MA, Bloch KD, Huang PL*, Buys ES*. Soluble guanylate cyclase alpha 1 beta 1 limits stroke size and attenuates neurological injury. Stroke 2010; 41: 1815-9.
    • Ling Y, Pong T, Vassiliou CC, Huang PL, Cima MJ. Implantable magnetic sensors measure cumulative exposure to cardiac biomarkers. Nature Biotechnol 2011, in press.

Reviews: Comments and Ratings

5.0out of 5(81 Ratings, 36 Comments)

November 2024

He is the best!!!


November 2024

The care I receive at MGH is second to none.


November 2024

Dr huang is very helpful, provides excellent care and I have 100% confidence in his advice and care


October 2024

I am very happy with Dr. Huang....He leaves no stone unturned!!


October 2024

Great!


October 2024

Very responsive, great job addressing my needs.


October 2024

Dr Haung is the best doctor I've had in 20 years!


October 2024

I have complete respect for and trust in Dr. Huang. He saved my life at my annual physical in 2019 with his early diagnosis of a protein issue which led to the discovery of my multiple myeloma. He is always there when I need him, and he answers my questions and calms my concerns. There is no finer concierge doctor than Dr. Huang. None.


September 2024

Always look forward to seeing Dr. Huang


September 2024

Dr. Huang is excellent and I feel like it is a health partnership. He listens very carefully and is very responsive to any concerns I have. I appreciate the time he spends with me.

View More
Ratings and Comments Powered by NRC Health