Robert Manguso, PhD of Krantz Family Center for Cancer Research Awarded GCTI 2023 Spark Grant

Congratulations to Robert Manguso, PhD, principal investigator in the Krantz Family Center for Cancer Research, for being awarded a 2023 Spark Grant by the Mass General Brigham Gene and Cell Therapy Institute (GCTI). One of six inaugural winners, Dr. Manguso will receive $250,000 to fund his work in rapid identification of nanobody chimeric antigen receptors using nanomice.

“I’m thrilled to receive this generous award for my lab’s work in the rapid development of novel nanobody-based CARs,” says Dr. Manguso. “With this funding, we hope to accelerate the development of CAR T cells targeting emerging solid tumor antigens so that these live-saving therapies can reach the clinic as quickly as possible.”

The Manguso Lab, based at the Krantz Center and the Broad Institute, endeavors to improve the treatment of cancer using immunotherapy, employing a range of approaches including mouse models, cellular immunology, functional genomics, and single cell profiling to understand how cancers evade the immune system and to identify new targets to enhance immune responses to tumors.

Learn more about Dr. Manguso’s groundbreaking research and the other 2023 Spark Grant Awardees here.