Research Spotlight: Comparing the GI Side Effects of Four Medications for Alcohol Use Disorder
Researchers found that injectable naltrexone had the fewest reported GI and liver-related side effects compared to the other drugs.
Department of Medicine
Contact Information
165 Cambridge Street
Suite 302
Boston,
MA
02114
Phone: 617-726-7872
Fax: 617-724-1122
Email: snigwekar@mgh.harvard.edu
My primary research focus is calciphylaxis (also known as calcific uremic arteriolopathy) and it aims to develop effective treatments and diagnostic tests for patients with calciphylaxis.
Calciphylaxis, a dermal arteriolar calcification disorder, has significant mortality and morbidity. I am leading multiple research studies in calciphylaxis patients. These studies address risk factors and pathogenesis of calciphylaxis and guide development and examination of novel treatments and diagnostic modalities for this highly fatal disease. Our team is currently enrolling patients in the first ever randomized controlled trial for calciphylaxis wherein we are testing vitamin K supplementation as a potential therapy. More details regarding this trial are available at Clinicaltrials.gov.Our team also aims to apply the knowledge gained from calciphylaxis research to investigate other forms of vascular calcifications.
I am also involved in the epidemiological and translational investigations in the areas of hyponatremia, nephrolithiasis and olfaction-malnutrition.
Learn more about the Calciphylaxis Program at Mass GeneralEvery day, our clinicians and scientists chart new terrain in biomedical research to treat and prevent human disease and advance patient care.
Calciphylaxis is a serious and rare disease. Your support of the program helps us learn more about the disease through to provide the best care.
We offer innovative, high-quality medical care, trains future medical leaders, and produces research that advances science and improves care.
Researchers found that injectable naltrexone had the fewest reported GI and liver-related side effects compared to the other drugs.
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Shadmehr (Shawn) Demehri, MD, PhD, is the corresponding author of a paper published in Cancer Cell, “Commensal papillomavirus immunity preserves the homeostasis of highly mutated normal skin.”
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Researchers work to understand how cells sense and respond to nutrients.
Researchers from Mass General have found that engaging in recommended weekly amounts of physical activity—either concentrated in one to two days or spread throughout the week—may reduce the risk of a broad range of conditions.
The Division of Nephrology at Massachusetts General Hospital is a leading provider of services for patients with kidney disease, including diagnosis and management of kidney diseases and medical management of renal transplantation.