Nicholas Dyson, PhD MGH Research Scholar Profile
MGH Research Scholar Nicholas Dyson, PhD, is studying the role of the retinoblastoma tumor suppressor, which is expressed in most cell types and enables them to stop dividing.
Understanding the Function of the Retinoblastoma Protein—A Key Tumor Suppressor
James and Shirley Curvey MGH Research Scholar 2012-2017
Investigator, Center for Cancer Research, Massachusetts General Hospital
Professor of Medicine, Mary B. Saltonstall Chair in Oncology, Harvard Medical School
The Dyson laboratory studies the role of the retinoblastoma tumor suppressor (pRB). pRB is expressed in most cell types and its functions enable cells to stop dividing.
pRB is inactivated in many types of cancer; a change that is thought to be an important step in tumor progression.
The Dyson lab has three main goals:
- To understand the molecular details how how pRB acts
- To know how the inactivation of pRB changes the cell
- To use these insights to target tumor cells