Jayaraj (Jay) Rajagopal, MD, was named the new incumbent of the Bernard and Mildred Kayden Endowed MGH Research Institute Chair.
The Rajagopal laboratory is interested in modern cellular and developmental biology approaches to reframing the cellular basis of lung biology. These inquiries serve as a framework to understand how the reactivation and distortion of normal developmental processes results in human lung disease.
His laboratory made the surprising discovery that a fully mature functional cell can durably dedifferentiate into a stem cell. His lab has also identified several new principles of cell communication during regeneration, as well as several new lung cell types including the initial description of pulmonary ionocytes. Current interests include establishing the functions of this new menagerie of cells and their roles in disease.
Dr. Rajagopal is an investigator in the Center for Regenerative Medicine at Massachusetts General Hospital, a professor of medicine at Harvard Medical School and a Howard Hughes Medical Institute (HHMI) Faculty Scholar. He is also an associate member at the Broad Institute and on the faculty of the Harvard Stem Cell Institute.
He directs the Stanbury Unit of the Mass General Department of Medicine that focuses on the training of young physician-scientists and he has been a Robertson Investigator of the New York Stem Cell Institute, a Kevin and Polly Maroni MGH Research Scholar and an Outstanding Investigator of the International Society for Stem Cell Research. Learn more about Dr. Rajagopal's work.
Margarita Alegría, PhD
The inaugural Harry G. Lehnert, Jr. and Lucille F. Cyr Lehnert Endowed MGH Research Institute Chair is Margarita Alegría, PhD.
Dr. Alegría joined the Mass General community as Chief of the Disparities Research Unit at the Massachusetts General Hospital and the Mongan Institute in 2015. Her career has focused on testing new models of care and interventions for improving health care and eliminating health care disparities for diverse populations.
She was Principal Investigator of the International Latino Research Partnership, which tested a model of integrated care for Latino immigrants with co-occurring substance and mental health problems in Barcelona, Madrid and Boston.
She also led an NIA/NIH-funded study examining how to successfully build collaborative research for the provision of evidence-based mental health and disability prevention treatments for racial/ethnic minority elders in community-based organizations. Dr. Alegría co-directed the National Latino and Asian American Study, the most comprehensive psychiatric epidemiology study of Latinos and Asian Americans ever conducted in the United States.Learn more about Dr. Algería's work .
The Helen T. Moerschner Endowed MGH Research Institute Chair in Women’s Health
Jill M. Goldstein, PhD, MPH
The inaugural incumbent of Helen T. Moerschner Endowed MGH Research Institute Chair in Women's Health is Jill M. Goldstein, PhD, MPH.
Dr. Goldstein, the Executive Director of the Women, Heart and Brain Global Initiative at Mass General, studies the co-occurrence of depression and heart disease, its impact on memory decline and Alzheimer's disease, and translates her research findings into sex-informed therapeutics and global policy initiatives.
"Women's health used to be primarily thought of as reproductive health," Dr. Goldstein says. "However, over the last 15-20 years, we have redefined women's health more broadly as the 'health of women,' that includes multiple organ systems and tissues, and how it differs from the health of men.
"The Helen T. Moerschner Endowed MGH Research Institute Chair in Women's Health represents the commitment of Mass General—one of the premier leading institutions in academic medicine and healthcare—to the importance of women's health and sex differences in medicine. I am honored and thrilled to be the first representative of this chair."
The Moerschner Endowed MGH Research Institute Chairs were made possible through the generous bequest from the late Marjorie D. Moerschner in honor of her parents. Learn more about Dr. Goldstein's work.
The Richard Moerschner Endowed MGH Research Institute Chair in Men's Health
Matthias Nahrendorf, MD, PhD
The Richard Moerschner Endowed MGH Research Institute Chair in Men's Health is Matthias Nahrendorf, MD, PhD.
The Nahrendorf laboratory focuses on the role of immunity in cardiovascular health and disease, specifically in atherosclerosis and heart failure. Of particular interest are the function, supply and production of leukocytes, and the signals that regulate hematopoiesis after injuries such as myocardial infarction (MI) or stroke. The Nahrendorf lab described that MI activates hematopoietic stem cells in the bone marrow, leading to an often harmful overproduction of white blood cells and a spike in systemic inflammation.
Recent discoveries include that risk factors such as chronic psychosocial stress and a sedentary life style (versus regular exercise) modulate the bone marrow stem cell niche, proliferation of myeloid progenitor cells, the leukocyte repertoire and cardiovascular inflammation. Resident heart macrophages, which are less inflammatory and do not derive from circulating cells, promote steady state functions such as cardiac conduction. Learn more about Dr. Nahrendorf's work.
Elizabeth G. Riley and Daniel E. Smith, Jr. Endowed MGH Research Institute Chair
Susan A. Slaugenhaupt, PhD
Dr. Slaugenhaupt is a human geneticist whose work focuses on two neurologic disorders, familial dysautonomia (FD) and mucolipidosis type IV (MLIV), as well as the common cardiac disorder mitral valve prolapse (MVP).
Discoveries in the Slaugenhaupt Lab have led to the successful implementation of critical population screening for FD and MLIV, the identification of genes for familial MVP, and more recently to the development of therapeutics for FD and MLIV. Dr. Slaugenhaupt also spearheads several programs and educational initiatives at Mass General, including a thriving undergraduate summer internship program.
Her Research Institute team works to promote science at Mass General by increasing interactions with industry, by fundraising for Research Institute initiatives, including partnering with individual philanthropists, their families and foundations and by promoting Mass General research to both internal and external audiences.
Since 2010 she has co-directed the Mass General Brigham Biobank at Mass General, an exciting initiative that will speed the translation of research discoveries into improved clinical care for patients.
In 2013, Dr. Slaugenhaupt was named an Elizabeth G. Riley and Daniel E. Smith, Jr. MGH Research Scholar 2013-2018. In 2016, she was honored with a prestigious Javits Neuroscience Investigator Award by the National Institute for Neurological Disorders and Stroke (NINDS), and in 2016 she was named one of the Top Ten Women to Watch in Science and Technology by the Boston Business Journal. She was elected to the Board of the American Society of Human Genetics in 2018 and she serves on the Board of Trustees at Eckerd College.
Learn more about Dr. Slaugenhaupt's work.
The Remondi Family Endowed MGH Research Institute Chair
Gary Tearney, MD, PhD
The inaugural incumbent of the Remondi Family Endowed MGH Research Institute Chair is Guillermo (Gary) Tearney, MD, PhD, of the Department of Pathology and the Wellman Center for Photomedicine.
Dr. Tearney's research is focused on developing groundbreaking new ways to take images of living cells inside the human body. His lab has developed a pill-sized device attached to a tether that can be swallowed by patients to capture high quality images of the gastrointestinal tract. Once the imaging is complete, the capsule can be removed using the tether.
The device, known as tethered capsule endoscopy, could significantly reduce the need for expensive and invasive surgical biopsies, and greatly improve the accuracy of diagnoses for Barrett's Esophagus, a precursor to esophageal cancer. Dr. Tearney is now working to translate the device into clinical practice.
"The award means a tremendous amount to me and is a highlight of my career. It is a great honor to have the Remondi Family name associated with the chair and to hold one of the first Endowed MGH Research Institute Chairs," Dr. Tearney says.
"This endowment will allow us to continually conduct high risk/high reward research that could not be supported by other funding mechanisms."Learn more about Dr. Tearney's work.
