Heart-healthy lifestyles linked to lower risk of future cancers

BOSTON – In addition to lowering risk of heart disease, maintaining a heart-healthy lifestyle may pay off in lower risk for developing cancer, researchers from Massachusetts General Hospital (MGH) and other centers in the United States and the Netherlands have found.

Looking at the potential link between cardiovascular disease (CVD) and cancer among participants in two large population-based health studies, Emily S. Lau, MD, and Jennifer E. Ho, MD, from the division of Cardiology at MGH and their co-authors found that traditional risk factors for CVD, including older age, male sex, and current or former smoking were all independently associated with increased risk of the development of cancer.

In addition, they found increased levels of natriuretic peptides – markers of stress on the heart – also predicted higher cancer risk among study participants.

Although participants who already had a history of heart disease before the study or experienced a cardiovascular event such as heart attack or heart failure after joining the study were not found to be at increased risk of developing cancers, those who had ideal cardiovascular health at study entry had lower risk of future cancers, the investigators reported in JACC: CardioOncology.

“We found an association between a heart-healthy lifestyle and a lower risk of cancer, and the opposite is true: that a less heart-healthy lifestyle is also associated with higher risk of cancer, but we can’t prove that there is causation in this epidemiologic study,” says Lau.

Lau and colleagues evaluated data from 20,305 participants in two large community-based, long-term health studies: the Framingham Heart Study and the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study. The participants were free of cancer at study entry.

The data included information on laboratory-proven cancers that occurred during the course of the study, CVD risk factors at study entry (including obesity, diabetes, high cholesterol and  high blood pressure), cardiovascular risk as measured by the 10-year atherosclerotic (ASCVD) risk score, established diagnostic markers for CVD such as the naturally occurring substances natriuretic peptides and cardiac troponins, CVD at study entry, and the American Heart Association (AHA) Life’s Simple 7 cardiovascular health score, a patient-reported measure of heart-healthy lifestyles.

The researchers found that traditional CVD risk factors such as age, sex, and smoking status were each associated with cancer. In addition, each 5% increase in the estimated 10-year ASCVD risk score was associated with a 16% increase in risk for cancer, and participants who were in the highest third of natriuretic peptide levels had a 40% greater risk of developing cancer than those in the lowest third.

Although participants with CVD at baseline and those who had a cardiovascular event such as a heart attack or stroke during the study were not at higher risk of subsequent cancer, those who most closely adhered to the AHA recommendations at study entry (manage blood pressure, control cholesterol, reduce blood sugar, get active, eat better, lose weight, stop smoking) had lower risk of future cancers.

Co-authors of the study are Samantha M. Paniagua, MPH, Elizabeth Liu, BS, Shawn X. Li, MD, Katherine Takvorian, and James L. Januzzi, Jr., MD (all MGH); Manol Jovani, MD, MPH (Johns Hopkins University); Navin Suthahar, MD, MSc and Rudolf A. de Boer, MD, PhD (University of Groningen, the Netherlands); Susan Cheng, MD (Cedars Sinai Medical Center, Los Angeles); Greta L. Splansky, MA, Ramachandran S. Vasan, MD, Martin G. Larson, ScD, and Daniel Levy, MD (Framingham Heart Study); Thomas J. Wang, MD (U. Texas Southwestern Medical Center, Dallas); Bernard Kreger, MD (Boston University School of Public Health).

About the Massachusetts General Hospital
Massachusetts General Hospital, founded in 1811, is the original and largest teaching hospital of Harvard Medical School. The Mass General Research Institute conducts the largest hospital-based research program in the nation, with annual research operations of more than $1 billion and comprises more than 9,500 researchers working across more than 30 institutes, centers and departments. In August 2020, Mass General was named #6 in the U.S. News & World Report list of "America’s Best Hospitals."