About Raghu Chivukula, MD, PhD

Dr. Chivukula studied cellular and molecular neuroscience at Johns Hopkins University prior to MD and PhD training in human genetics and molecular biology at Johns Hopkins University School of Medicine. He completed residency training in internal medicine at Massachusetts General Hospital, clinical fellowships in pulmonary disease and critical care medicine at Harvard Medical School, and postdoctoral research training at the Whitehead Institute for Biomedical Research.

As an Assistant Professor of Medicine and Surgery at Harvard Medical School, an attending physician at Massachusetts General Hospital, and an Associate Member of the Broad Institute of MITT and Harvard, Dr. Chivukula is actively involved in clinical care, research, and teaching. Dr. Chivukula’s clinical interests include critical care medicine and genetic forms of lung disease. His research interests center on the function and dysfunction of specialized subcellular organelles, particularly in rare pulmonary disorders. As an educator, Dr. Chivukula participates in teaching medical students, graduate students, residents, and fellows in didactic and clinical settings.

Departments, Centers, & Programs:

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Locations

Boston: Massachusetts General Hospital

Massachusetts General Hospital
55 Fruit St.
Boston, MA 02114
Phone: 617-726-2000

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Medical Education

  • MD, Johns Hopkins University School of Medicine
  • Residency, Massachusetts General Hospital
  • Fellowship, Massachusetts General Hospital

American Board Certifications

  • Critical Care Medicine, American Board of Internal Medicine
  • Internal Medicine, American Board of Internal Medicine
  • Pulmonary Disease, American Board of Internal Medicine

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Research

The Chivukula Laboratory is housed within the Center for Genomic Medicine at Massachusetts General Hospital and Harvard Medical School. Dr. Chivukula's prior work has elucidated novel in vivo roles for microRNAs in mammalian tissue regeneration and cancer and has revealed the basis for a previously undescribed form of human lung disease caused by short airway cilia. The lab is currently focused on understanding how these and Mendelian genetic disorders dysregulate subcellular compartments to cause disease.

Dr. Chivukula's research has been recognized with the Michael A. Shanoff Award, selection to Forbes Magazine ?30 Under 30?, selection as a fellow of the Parker B. Francis Foundation, the Burroughs Wellcome Career Award for Medical Scientists, and the ASCI Young Physician-Scientist Award.

Publications

  • Chivukula RR*, [?] Alkuraya FS*, Sabatini DM. A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance. Nature Medicine. 26(2), 244-251 (2020). *corresponding

    Chivukula RR, Maley JH, Dudzinski DM, Hibbert, KA, Hardin, CC. Evidence-based management of the critically ill adult with SARS-CoV-2 infection. Journal of Intensive Care Medicine. 10.1177/0885066620969132 (2020).

    Taylor MS*, Chivukula RR*, [...] Kradin RL. Delayed alveolar epithelialization: a distinct pathology in diffuse acute lung injury. Am. J. Respir. Crit. Care Med. 197, 522?524

    (2018). *equal contribution

    Chivukula RR*, Shi G*, [...] Mendell JT. An essential mesenchymal function for miR-143/145 in intestinal epithelial regeneration. Cell 157, 1104-16 (2014). *equal contribution

    Kota J, Chivukula RR, [...] Mendell JT. Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 137, 1005?1017 (2009).

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