About Natalie Wolkow, MD, PhD

Departments, Centers, & Programs:

Clinical Interests:

Treats:

Locations

Mass Eye and Ear at Longwood
800 Huntington Ave.
Boston, MA 02115
Phone: 617-936-6156

Mass Eye and Ear
243 Charles St.
Boston, MA 02114
Phone: 617-523-7900

Medical Education

  • MD, Raymond & Ruth Perelman School of Med. at the University of Pennsylvania
  • Residency, Massachusetts Eye and Ear
  • Fellowship, Massachusetts Eye and Ear

American Board Certifications

  • Ophthalmology, American Board of Ophthalmology

Research

Dr. Wolkow has a strong laboratory research background, with PhD training in cell and molecular biology and fellowship training in ophthalmic pathology. She combines this background with her clinical interests in ophthalmic plastic surgery to engage in research that strives to improve patient care and develop novel treatments for patients with orbital, eyelid and lacrimal diseases.

Dr. Wolkow has several current research interests and ongoing projects, including research into orbital and periorbital malignancies. Recently, she published on the expression of PD-L1 and PD-L2 in ocular adnexal sebaceous carcinoma, squamous carcinoma and adenoid cystic carcinoma. She is recognized for her expertise in the histopathology of periocular foreign materials, such as cosmetic facial fillers and orbital implants, and has several publications on the subject. Dr. Wolkow has ongoing collaborations studying the periocular microbiome and periorbital infections, and she contributes to the international thyroid eye disease biobank. She has a strong commitment to improving resident and fellow surgical training, and is invested in the continued surgical growth of established surgeons and surgical innovation. She has developed a wet lab based surgical curriculum in Oculoplastics for the Mass Eye and Ear ophthalmology residents and is evaluating its effect on resident and fellow surgical performance.

Publications

  • 1. Wai KM, Wolkow N, Freitag SK. Orbital Fat Herniation Through the Superior Orbital Fissure in Thyroid Eye Disease. Ophthalmic Plast Reconstr Surg. 2020 Jul 30. 

    2. Wolkow N, Jakobiec FA, Afrogheh AH, Pai SI, Faquin WC. High Expression of PD-L1 and PD-L2 in Ophthalmic Sebaceous Carcinoma: The Case for a Clinical Trial of Checkpoint Inhibitors. Am J Ophthalmol. 2020 Jul 27. 

    3. Chiou C, Wolkow N, Freitag SK. Eyelid Keratoacanthoma in an 86-Year-Old Man: Clinical and Histopathologic Features. Ophthalmic Plast Reconstr Surg. 2020 Jul 23. 

    4. Zhou C, Singh A, Qian G, Wolkow N, Dohlman CH, Vavvas DG, Chodosh J, Paschalis EI. Microporous Drug Delivery System for Sustained Anti-VEGF Delivery to the Eye. Transl Vis Sci Technol. 2020 Jul; 9(8):5.

    5. Wai KM, Wolkow N, Yoon MK. Displaced bone fragment simulating an orbital foreign body. Orbit. 2020 Jun 11; 1-2.

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Reviews: Comments and Ratings

4.8out of 5(263 Ratings, 91 Comments)

May 2025

Excellent service


April 2025

Dr. Natalie Wolkow is knowledgeable perceptive, helpful, and kind. her analysis of the status of my Ptosis seems very logical to me.


April 2025

This is my first visit and I truly felt comfortable and informed I was seen early which was great Everyone was pleasant


April 2025

Much better experience this time. I did not have a good experience seeing Dr. [redacted] and her office never got back to me about insurance glitch. This was a completely different experience.


April 2025

Very thorough and easy to understand.


April 2025

Very professional.


April 2025

Thorough and detailed. Reassuring and a delivered good news.


April 2025

Dr. Wolkow is a smart, engaging person who communicates very clearly. All interactions with her were excellent. [redacted]


April 2025

Very thorough, patient, caring,competent.


March 2025

Dr. Wolkow was very professional, and friendly at the same time. She examined my eyelids thoroughly, took measurements, and provided information. She clearly took various factors into consideration when answering my questions -- even things that didn't even occur to me before she said it. As an example, when she suggested one of the three types of ... Read More

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