About Natalie Wolkow, MD, PhD

Departments, Centers, & Programs:

Clinical Interests:

Treats:

Locations

Mass Eye and Ear at Longwood
800 Huntington Ave.
Boston, MA 02115
Phone: 617-936-6156

Mass Eye and Ear
243 Charles St.
Boston, MA 02114
Phone: 617-523-7900

Medical Education

  • MD, Raymond & Ruth Perelman School of Med. at the University of Pennsylvania
  • Residency, Massachusetts Eye and Ear
  • Fellowship, Massachusetts Eye and Ear

American Board Certifications

  • Ophthalmology, American Board of Ophthalmology

Research

Dr. Wolkow has a strong laboratory research background, with PhD training in cell and molecular biology and fellowship training in ophthalmic pathology. She combines this background with her clinical interests in ophthalmic plastic surgery to engage in research that strives to improve patient care and develop novel treatments for patients with orbital, eyelid and lacrimal diseases.

Dr. Wolkow has several current research interests and ongoing projects, including research into orbital and periorbital malignancies. Recently, she published on the expression of PD-L1 and PD-L2 in ocular adnexal sebaceous carcinoma, squamous carcinoma and adenoid cystic carcinoma. She is recognized for her expertise in the histopathology of periocular foreign materials, such as cosmetic facial fillers and orbital implants, and has several publications on the subject. Dr. Wolkow has ongoing collaborations studying the periocular microbiome and periorbital infections, and she contributes to the international thyroid eye disease biobank. She has a strong commitment to improving resident and fellow surgical training, and is invested in the continued surgical growth of established surgeons and surgical innovation. She has developed a wet lab based surgical curriculum in Oculoplastics for the Mass Eye and Ear ophthalmology residents and is evaluating its effect on resident and fellow surgical performance.

Publications

  • 1. Wai KM, Wolkow N, Freitag SK. Orbital Fat Herniation Through the Superior Orbital Fissure in Thyroid Eye Disease. Ophthalmic Plast Reconstr Surg. 2020 Jul 30. 

    2. Wolkow N, Jakobiec FA, Afrogheh AH, Pai SI, Faquin WC. High Expression of PD-L1 and PD-L2 in Ophthalmic Sebaceous Carcinoma: The Case for a Clinical Trial of Checkpoint Inhibitors. Am J Ophthalmol. 2020 Jul 27. 

    3. Chiou C, Wolkow N, Freitag SK. Eyelid Keratoacanthoma in an 86-Year-Old Man: Clinical and Histopathologic Features. Ophthalmic Plast Reconstr Surg. 2020 Jul 23. 

    4. Zhou C, Singh A, Qian G, Wolkow N, Dohlman CH, Vavvas DG, Chodosh J, Paschalis EI. Microporous Drug Delivery System for Sustained Anti-VEGF Delivery to the Eye. Transl Vis Sci Technol. 2020 Jul; 9(8):5.

    5. Wai KM, Wolkow N, Yoon MK. Displaced bone fragment simulating an orbital foreign body. Orbit. 2020 Jun 11; 1-2.

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Reviews: Comments and Ratings

4.8out of 5(269 Ratings, 91 Comments)

April 2025

Very thorough, patient, caring,competent.


March 2025

My surgeon, she was very competent and she knew what she was doing. I would recommend her to anyone.


March 2025

[redacted] I got a call from the office in advance of coming in that she was in emergency surgery earlier in the day and that my appointment would be late. That was in fact the case. Everything else about the appointment was exactly as I hoped and I was not at all disappointed to be seen later in the day. [redacted]


March 2025

Dr. Wolkow is very professional, kind and extremely knowledgeable. I would highly recommend her.


March 2025

Excellent manner and very professional


March 2025

Dr Wolkow was extremely knowledgeable and understanding of my condition, and the questions I had.


March 2025

And the professionals have treated me well every time I've visited, that's all there is to it. They've treated me well and very well the last time I went, which was just this month.


March 2025

Top notch service!


March 2025

Explanations of procedures, objectives, limitations after surgery, stages of recovery, results anticipated as to increased field of vision, potential sight improvement ,


March 2025

I went with my sister to the consultation and I am very happy because they showed me a lot of respect. They were very patient and they explained to me what they had to explain very respectfully, and I am very happy. I also recommend my friends and family to go because they are respectful.

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