About Natalie Wolkow, MD, PhD

Departments, Centers, & Programs:

Clinical Interests:

Treats:

Locations

Mass Eye and Ear at Longwood
800 Huntington Ave.
Boston, MA 02115
Phone: 617-936-6156

Mass Eye and Ear
243 Charles St.
Boston, MA 02114
Phone: 617-523-7900

Medical Education

  • MD, Raymond & Ruth Perelman School of Med. at the University of Pennsylvania
  • Residency, Massachusetts Eye and Ear
  • Fellowship, Massachusetts Eye and Ear

American Board Certifications

  • Ophthalmology, American Board of Ophthalmology

Research

Dr. Wolkow has a strong laboratory research background, with PhD training in cell and molecular biology and fellowship training in ophthalmic pathology. She combines this background with her clinical interests in ophthalmic plastic surgery to engage in research that strives to improve patient care and develop novel treatments for patients with orbital, eyelid and lacrimal diseases.

Dr. Wolkow has several current research interests and ongoing projects, including research into orbital and periorbital malignancies. Recently, she published on the expression of PD-L1 and PD-L2 in ocular adnexal sebaceous carcinoma, squamous carcinoma and adenoid cystic carcinoma. She is recognized for her expertise in the histopathology of periocular foreign materials, such as cosmetic facial fillers and orbital implants, and has several publications on the subject. Dr. Wolkow has ongoing collaborations studying the periocular microbiome and periorbital infections, and she contributes to the international thyroid eye disease biobank. She has a strong commitment to improving resident and fellow surgical training, and is invested in the continued surgical growth of established surgeons and surgical innovation. She has developed a wet lab based surgical curriculum in Oculoplastics for the Mass Eye and Ear ophthalmology residents and is evaluating its effect on resident and fellow surgical performance.

Publications

  • 1. Wai KM, Wolkow N, Freitag SK. Orbital Fat Herniation Through the Superior Orbital Fissure in Thyroid Eye Disease. Ophthalmic Plast Reconstr Surg. 2020 Jul 30. 

    2. Wolkow N, Jakobiec FA, Afrogheh AH, Pai SI, Faquin WC. High Expression of PD-L1 and PD-L2 in Ophthalmic Sebaceous Carcinoma: The Case for a Clinical Trial of Checkpoint Inhibitors. Am J Ophthalmol. 2020 Jul 27. 

    3. Chiou C, Wolkow N, Freitag SK. Eyelid Keratoacanthoma in an 86-Year-Old Man: Clinical and Histopathologic Features. Ophthalmic Plast Reconstr Surg. 2020 Jul 23. 

    4. Zhou C, Singh A, Qian G, Wolkow N, Dohlman CH, Vavvas DG, Chodosh J, Paschalis EI. Microporous Drug Delivery System for Sustained Anti-VEGF Delivery to the Eye. Transl Vis Sci Technol. 2020 Jul; 9(8):5.

    5. Wai KM, Wolkow N, Yoon MK. Displaced bone fragment simulating an orbital foreign body. Orbit. 2020 Jun 11; 1-2.

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Reviews: Comments and Ratings

4.8out of 5(253 Ratings, 95 Comments)

February 2025

Very professional and great doctor!


February 2025

Excellent, caring


February 2025

Hello, Natalie was terrific. I've already recommended her to my family members. I've been on a very long road trying to get something done about this eye. She was professional, she was fast, she was thorough, and I couldn't ask for anybody better. [redacted] Thank you. Bye.


February 2025

Dr Wolkow diagnosed me immediately and I've been in treatment with her [redacted] for about 2 years now. [redacted] I trust Dr Wolkow 100% everytime with this procedure. Her and [redacted], her secretary are the absolute best. I will never go to another Dr for this blepharospasm procedure, only Dr Wolkow. [redacted]


February 2025

I was very nervous to have this procedure as I had done this procedure in another facility with much pain and little relief. Dr. Wolkow and her nurse, [redacted], really took their time to explain everything and talk through all options. They also took an additional 20 or so minutes to make sure that I was fully numb. I am very happy with my care ... Read More


February 2025

Hi, thank you so much. My name is Nicole Lyons. I was recently seen by Dr. Wolkow and her staff. Her and her staff were so amazing. They were able to explain everything to me and they were super caring and understanding. I really recommend her as a provider and her staff is just a really great experience.


February 2025

Natalie is a fantastic doctor. Absolutely no complaints at all. Very, very good.


February 2025

Dr. Wolkow was thorough and extremely knowledgeable about my eye condition. She explained what was going on and how to fix it. I was completely satisfied and more importantly felt comfortable with her as my doctor.


January 2025

The provider and other staff were very professional, knowledgeable and kind.


January 2025

I am thankful to have the opportunity to receive this top medical care from Dr. Wolkow and her staff.

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