About Alessio Fasano, MD

Clinical Interests:

Treats:

Languages:

Locations

Mass General for Children: Pediatric Gastroenterology & Nutrition Program
55 Fruit St.
Yawkey Center for Outpatient Care
Suite 6B
Boston, MA 02114
Phone: 617-726-8705

Medical Education

  • MD, University of Naples School of Medicine
  • Residency, University of Naples School of Medicine

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.


Research

Dr. Fasano is director of the Mucosal Immunology and Biology Research Center at Mass General for Children. Dr. Fasano's research established that celiac disease affects approximately 1 percent of the U.S. population, a significantly higher number than previously believed, and helped define gluten sensitivity as a condition on the spectrum of gluten-related disorders. His research also uncovered the role that impairment of the tight junctions between intestinal enterocytes plays in the development of celiac disease.

During research designed to develop a cholera vaccine, Dr. Fasano uncovered a toxin, zonula occludens, which causes diarrhea by loosening the tight junctions and allowing intestinal permeability. Subsequently, he identified the protein zonulin, which controls this process. He has since established the role of zonulin in the pathogenesis of a number of autoimmune diseases, including celiac disease, type 1 diabetes, and certain cancers and diseases of the nervous system.

Publications

Reviews: Comments and Ratings

4.9out of 5(38 Ratings, 14 Comments)

January 2025

I'm so thankful Dr. Fasano is in Boston--I had really struggled with my severe gluten allergy and his expertise has really helped me


October 2024

Good listener.


September 2024

I am grateful that I have access to a world renowned expert on celiac disease for my care. Dr. Fasano is always attentive, thoughtful and kind.


August 2024

Dr. Fasano is just the best there is. I mean, what can one say? He's an expert. He's affable, informative, very kind, has a great memory, and the people that work with him are also outstanding. Can't say enough good things about him.


August 2024

He is wonderful, caring and so smart!


August 2024

Dr. Fasano was compassionate, professional and seemed to really want to help me.


August 2024

Dr. Fasano is the most extraordinary doctor. He's off-the-charts brilliant and incredibly kind. He always takes the time necessary to explain things, and he responds promptly to messages on the patient portal. I don't know how he does all that he does, but I'm so grateful for his care and compassion. He saved my life, and he continues to help me ... Read More


July 2024

Looking forward for follow up


July 2024

Fantastic experience! Very impressed.


June 2024

Congratulations. He's an excellent doctor.

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