About Jacob Dal-Bianco, MD

Watch a video about my work

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Locations

Mass General Heart Center
55 Fruit St.
Boston, MA 02114
Phone: 866-644-8910

Medical Education

  • MD, University of Vienna School of Medicine
  • Residency, Mayo Clinic
  • Fellowship, Cedars Sinai Medical Center
  • Fellowship, Massachusetts General Hospital

American Board Certifications

  • Cardiovascular Disease, American Board of Internal Medicine
  • Internal Medicine, American Board of Internal Medicine

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.


Research

Dr. Dal-Bianco's research aims to explore and to understand the biological mechanisms of why heart valves become diseased and dysfunctional. His aim is to develop medical therapies that prevent the development or stop the progression of heart valve disease to maintain healthy, normally functioning heart valves.

Dr. Dal-Bianco explores the adaptive mechanisms of the mitral valve following a heart attack and his research suggests that mitral valve leaflets actively grow and adapt, but also become scarred (=fibrosed), stiff and thick. This novel  observation contradicts the notion of mitral valve leaflets being merely passive tissue flaps.  Understanding the mechanisms of  mitral valve adaptation could lead to new therapeutic opportunities with the goal to prevent leaflet fibrosis to maintain leaflet flexibility and thus preserve a good leaflet seal (coaptation).  Developing such therapies will reduce the amount of mitral regurgitation and improve heart failure symptoms. This multidisciplinary research project is in collaboration with Dr. Robert Levine, Dr. Elena Aikawa and Dr. Joyce Bischoff.

A new research direction will now  investigate prevention of rheumatic heart valve disease progression.

Publications