John Stone, MD, MPH
About John Stone, MD, MPH
Research: I co-founded the Vasculitis Center at Johns Hopkins University and directed a multi-center, randomized clinical trial in Wegener's granulomatosis. The results of this trial were published in The New England Journal of Medicine (2005). I am currently the Co-PI of a second multi-center clinical trial in ANCA-associated vasculitis: Rituximab in ANCA-Associated Vasculitis HRAVe). The primary results of this trial were recently published in The New England Journal of Medicine (2010).
My most current research interest pertains to an emerging disease known as IgG4-related systemic disease (IgG4-RSD). My research group at the MGH made the seminal observation that rituximab therapy leads to the targeted reduction of the IgG4 subclass of immunoglobulins in this disorder.
Teaching: I gave the Sir James Cameron Lecture at the Royal College of Physicians (Edinburgh) in 2003. I delivered the Dunlop-Dottridge Lecture at the Canadian Rheumatology Association (2007), and gave the Woodbury Lecture at Dalhousie University in 2010.
Clinical Interests:
- ANCA-associated vasculitis
- Aortitis
- Behcet's syndrome
- Cutaneous vasculitis
- Dermatomyositis
- Giant cell arteritis
- Gout and pseudogout
- IgG4-related systemic disease
- Lupus
- Rheumatoid arthritis
Treats:
- Adult
Languages:
- German, Spanish
Locations
Mass General Rheumatology
55 Fruit St.
Yawkey Center for Outpatient Care
Suite 4B
Boston, MA 02114
Phone: 617-726-7938
Medical Education
- MD, Harvard Medical School
- Residency, Johns Hopkins Hospital***
- Fellowship, UC San Francisco
Accepted Insurance Plans
- Aetna
- Beech Street
- Blue Cross Blue Shield
- Blue Cross Blue Shield Medicare
- Cigna
- Commonwealth Care Alliance
- Coventry
- Fallon Health
- Harvard Pilgrim Health Care
- Humana
- Maine Community Health Options
- Mass General Brigham Health Plan
- MassHealth
- Medicaid CT
- Medicaid ME
- Medicaid NH
- Medicaid RI
- Medicaid VT
- Medicare
- Medicare ACO
- Multiplan
- Senior Whole Health
- TriCare
- Tufts Health Plan
- United Health Care
- Wellpoint
- WellSense
- WellSense NH
Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.
Research
Research: I co-founded and directed the Vasculitis Center at Johns Hopkins University, where I directed a multi-center, randomized clinical trial in Wegener's granulomatosis. The results of this trial were published in The New England Journal of Medicine (2005). This trial, the first-ever NIH-funded randomized clinical trial in vasculitis, paved the way for subsequent trials and investigations in vasculitis on an international scale.
I am currently the Co-PI of a second multi-center clinical trial in ANCA-associated vasculitis: Rituximab in ANCA-Associated Vasculitis (RAVe). This trial, which includes 8 centers in both the United States and Europe, is sponsored by the Immune Tolerance Network (NIAID). The primary results of this trial were recently published in The New England Journal of Medicine (2010).
My most current research interest pertains to an emerging disease known as IgG4-related systemic disease (IgG4-RSD). My research group at the MGH made the seminal observation that rituximab therapy leads to the targeted reduction of the IgG4 subclass of immunoglobulins in this disorder, with maintenance of normal levels of other IgG subclasses.
Publications
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Selected Research Investigation Publications
25. The WGET Research Group (Principal Investigator and Chairman, Writing Committee: Stone JH). Etanercept Plus Standard Therapy for Wegener's Granulomatosis. N Engl J Med 2005;352(4):351-61.
Khosroshahi A, Bloch DB, Deshpande V, Stone JH. Rituximab therapy leads to swift decline of serum IgG4 levels and prompt clinical improvement in IgG4-related systemic disease. Arthritis & Rheumatism 2010; 62:1755-62.
68. Stone JH, Merkel PA, Spiera R et al. Rituximab Compared With Cyclophosphamide For Remission Induction In ANCA-Associated Vasculitis. N Engl J Med 2010; 363:221-32.
Ramos-Casals M, Stone JH, Cid MC, Bosch X. The Cryoglobulinemias. The Lancet (In press, February, 2011).