Dr. Filbin's interest focuses on early identification, characterization, and management of infection and sepsis. Dr. Filbin was site investigator and co-author on a practice-changing interventional trial in sepsis that aimed to validate protocolized goal-directed therapy with and without invasive monitoring versus standard of care (Protocolized Care for Early Septic Shock – Process ). This trial focused global attention on early sepsis detection as the potential key to making a difference in sepsis outcomes. Dr. Filbin was instrumental in conducting two related NIH-funded studies that both sought to characterize circulating serum protein profiles associated with short- and long-term outcomes (Endothelial Cell Signaling and Microcirculation in Sepsis and Protocolized Goal-directed Resuscitation of Septic Shock to Prevent Acute Kidney Injury - ProGReSS-AKI). Dr. Filbin recently co-authored a large multicenter trial investigating the role of procalcitonin in reducing antibiotic utilization in respiratory infections, and led MGH as the top enroller (Procalcitonin Antibiotic Consensus Trial – ProACT). Dr. Filbin currently coordinates enrollment at MGH in the Emergency Department for the PETAL Network trials (Prevention and Early Treatment of Acute Lung Injury).