Does nerve damage contribute to “long-COVID” symptoms?
Almost all post-COVID neuropathy appears due to infection-triggered immune dysfunction that is potentially treatable.
Associate Professor of Neurology,
Harvard Medical School
Associate in Neurology,
Massachusetts General Hospital
Assistant in Pathology (Neuropathology),
Massachusetts General Hospital
Dr. Oaklander is Associate Professor of Neurology at Harvard Medical School and Assistant in Pathology (Neuropathology) at the Massachusetts General Hospital. She received a B.S. in Neuroscience from Cornell University and M.D. and Ph.D. degrees from the Albert Einstein College of Medicine. After neurology residency at UMDNJ, she undertook postdoctoral training at Johns Hopkins and joined their Neurosurgery faculty until moving to MGH, where she attends for the neurology service and directs the neurodiagnostic skin-biopsy laboratory that diagnoses small-fiber polyneuropathy. Dr. Oaklander directs the Nerve Unit, an NIH, DoD, and foundation-funded laboratory that studies peripheral nerve problems. She is known for discoveries on complications of shingles, Complex Regional Pain Syndrome and small-fiber polyneuropathy. She has more than 100 publications and serves on the editorial board of several journals. She is a Fellow of the American Neurological Association and the American Academy of Neurology. She serves on advisory and review panels for the NIH, the VA, and the Institute of Medicine.
Visit her Neuropathy Commons website.
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Mass General Neurology
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Selected Publications
Faignart N, Nguyen KH, Soroken C, Poloni C, Downs HM, Laubscher B, Korff C, Oaklander AL*, Roulet Perez E* (2020). Acute monophasic erythromelalgia in five children diagnosed as small-fiber neuropathy. Eur J Pediatric Neurology.
Kelley M, Oaklander AL Association of small-fiber polyneuropathy with 3 previously unassociated rare missense SCN9A variants. Can J Pain, 2020;4:19-29, DOI: 10.1080/24740527.2020.1712652
Oaklander AL, Sharma S, Kessler K, Price BH. Persistent Genital Arousal Disorder: A special sense neuropathy. PAIN Reports, 2020.
Fridman V, Suriyanarayanan S, Novak P, David WS, Macklin E, McKenna-Yasek D, Walsh K, Aziz-Bose R, Oaklander AL, Brown RH, Hornemann T, Eichler F. Randomized Trial of L-Serine in Patients with Hereditary Sensory and Autonomic Neuropathy Type 1. Neurology, 2019;92:e1-e12. PMID: 30626650
Liu X#, Treister R#, Lang M#, Oaklander AL. IVIg for apparently autoimmune small-fiber polyneuropathy: First analysis of efficacy and safety. Therapeutic Advances in Neurological Disorders 2018;11:1-12. PMID: 29403541
* indicates shared first or last authorship, # indicates a formally mentored co-author
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Almost all post-COVID neuropathy appears due to infection-triggered immune dysfunction that is potentially treatable.
Results from a new study by investigators at Massachusetts General Hospital indicate that persistent genital arousal disorder can be caused by altered firing of nerves that carry sensations from the genitalia or by damage to the lowest parts of the spinal cord.
An analysis of the medical records of patients treated at Massachusetts General Hospital for an often-mysterious condition involving damage to small nerve fibers supports the hypothesis that some cases are caused by autoimmune disease and also identifies the first effective treatment option.