About Gary Brenner, MD, PhD

Clinical Interests:

Treats:

Locations

Mass General Anesthesia and Pain Medicine
55 Fruit St.
Gray Bigelow Building
Suite 444
Boston, MA 02114
Phone: 617-726-8810

Medical Education

  • MD, University of Rochester, School of Medicine and Dentistry
  • Residency, Massachusetts General Hospital
  • Fellowship, Massachusetts General Hospital

American Board Certifications

  • Pain Medicine, American Board of Anesthesiology

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.


Research

Research Areas

  • Development animal models and gene therapy for the neurofibromatoses.
  • Investigation of nociceptive circuits in the brain utilizing behavioral testing and functional imaging in the context of optogenetic modulation.

Description of Research   

My laboratory currently focuses efforts on two projects.  The first involves the development of novel therapeutic strategies for the treatment of Schwann-cell derived nerve sheath tumors.  In particular, we are utilizing adenovirus associated vectors to deliver caspase-1 to tumor cells.  Delivery of this apoptosis-generating transgene both directly kills tumor cells in which it is expressed and activates anti-tumor host responses.  We are investigating the mechanisms through which our vector kills tumor and are developing the therapeutic strategy for translation into phase 0/1 clinical trials.

The second project utilizes optogenetic modulation of brain circuits to investigate nociceptive processing that occurs in the context of nociceptive sensitization associated with peripheral nerve injury.  This approach may improve the positive predictive value for preclinical modeling of clinical pain.

Publications

  • Select Publications:

    • Brenner GJ, Felten SY, Felten DL, Cohen N and Moynihan JA.  Chemical sympathectomy is associated with increased pulmonary metastases.  Journal of Neuroimmunology.  1992;37:191-202.
    • Brenner GJ, Cohen N and Moynihan JA.  Similar immune response to nonlethal infection with Herpes Simplex virus-1 in sensitive (BALB/c) and resistant (C57Bl/6) mice.  Cellular Immunology.  1994;157:510-24.
    • Ji RR, Baba H, Brenner GJ and Woolf CJ. Nociceptive specific activation of ERK in spinal neurons contributes to pain hypersensitivity.  Nature Neuroscience. 1999;2:1114-9.
    • Prabhakar S, Brenner GJ, Tannous BA, Sena-Esteves M and Breakefield XO.  Imaging and therapy of experimental schwannomas using HSV amplicon vector encoding apoptotic protein under control of a Schwann cell promoter.  Cancer Gene Therapy.  2010;17(4):266-74.
    • Saydam O, Ozdener GB, Senol O, Mizrak A, Prabhakar  P, Stemmer-Rachamimov AO, Breakefield XO and Brenner GJ.  A novel imaging-compatible sciatic nerve schwannoma model.  Journal of Neuroscience Methods. 2011:195(1)75-77.
    • Brenner GJ, Nemark JL and Raemer D. A Curriculum and Cases for Pain Medicine Crisis Resource Management Education.  Anesthesia and Analgesia. In press.
    • Prabhakar S, Taherian M, Gianni D, Conlon TJ, Fulci J, Brockmann J, Stemmer-Rachamimov A, Sena-Esteves M,  Breakefield XO and Brenner GJ. Regression of Schwannomas induced by AAV-Mediated Delivery of Caspase-1. Human Gene Therapy. In press.

     

Reviews: Comments and Ratings

4.9out of 5(65 Ratings, 26 Comments)

June 2025

Dr. Brenner is absolutely wonderful. He is caring, he remembers his clients, or his patients, I'm sorry, and all of his fellows are well-informed, polite, they listen. It's one of the best experiences I've ever had in any doctor's office.


June 2025

I've been a patient of Dr. Gary Brenner's for 15 years plus. I have always found Dr. Brenner to be extremely intelligent, very patient, caring, and extremely helpful in regards to my overall health maintenance. I would suggest Dr. Brenner for any pain-related issues. That the human body may experience. He is just a wonderful, wonderful doctor. ... Read More


June 2025

it would have been nice if the front desk staff and the medical assistant introduced themselves by name, especially since i was a new patient to this practice.


May 2025

I saw two doctors the day of my appointment, they were both respectful, kind and listened to my issues with my back pain. They began a regimen that I how will help and am having an MRI next week. It was a great experience


May 2025

The Dr was extremely polite. He was also professional. knowledgeable and kind. So was the Dr working with him.


May 2025

Very professional, nice office atmosphere, polite


May 2025

Excellent doctor, I was treated with great care. Dr Brenner is an exceptional physician. Listens well and cares greatly about my health. I am very grateful for his support and advice. Always a pleasant and compassionate person.


May 2025

Dr. Brenner is the best! He has recommended the treatment of spinal cord stimulation and it has been quite successful. His expert care has been very reassuring and calming.


April 2025

Hopeful experience thanks


April 2025

Dr. Brenner was terrific.

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