Director, Pain Medicine Fellowship, Massachusetts General Hospital
Associate Professor, Harvard Medical School
Gary J. Brenner currently sees patients at the Massachusetts General Hospital Pain Management Center where he is the Director of the Mass General Pain Medicine Fellowship. He is an Associate Professor in Anesthesia at Harvard Medical School. Dr. Brenner runs an NIH-funded lab focused on developing gene therapy for the often painful peripheral nervous system tumors associated with neurofibromatosis. He also conducts neuroscience research on the mechanism of action of opioids in the brain, and has authored more than 45 articles, reviews, chapters, and abstracts on gene therapy strategies for NF tumors, the pathophysiology of pain, basic pain mechanisms and immune function, and clinical approaches to chronic pain. Dr. Brenner currently has several national leadership positions related to pain medicine education/training. He completed his MD and PhD degrees at the University of Rochester School of Medicine and Dentistry, and completed an anesthesiology residency and a pain medicine fellowship at the Massachusetts General Hospital.
Clinical Interests:
Treats:
Mass General Anesthesia and Pain Medicine
55 Fruit St.
Gray Bigelow Building
Suite 444
Boston, MA 02114
Phone: 617-726-8810
Medical Education
American Board Certifications
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My laboratory currently focuses efforts on two projects. The first involves the development of novel therapeutic strategies for the treatment of Schwann-cell derived nerve sheath tumors. In particular, we are utilizing adenovirus associated vectors to deliver caspase-1 to tumor cells. Delivery of this apoptosis-generating transgene both directly kills tumor cells in which it is expressed and activates anti-tumor host responses. We are investigating the mechanisms through which our vector kills tumor and are developing the therapeutic strategy for translation into phase 0/1 clinical trials.
The second project utilizes optogenetic modulation of brain circuits to investigate nociceptive processing that occurs in the context of nociceptive sensitization associated with peripheral nerve injury. This approach may improve the positive predictive value for preclinical modeling of clinical pain.
Select Publications:
Dr. Brenner is absolutely wonderful. He is caring, he remembers his clients, or his patients, I'm sorry, and all of his fellows are well-informed, polite, they listen. It's one of the best experiences I've ever had in any doctor's office.
I've been a patient of Dr. Gary Brenner's for 15 years plus. I have always found Dr. Brenner to be extremely intelligent, very patient, caring, and extremely helpful in regards to my overall health maintenance. I would suggest Dr. Brenner for any pain-related issues. That the human body may experience. He is just a wonderful, wonderful doctor. ... Read More
it would have been nice if the front desk staff and the medical assistant introduced themselves by name, especially since i was a new patient to this practice.
I saw two doctors the day of my appointment, they were both respectful, kind and listened to my issues with my back pain. They began a regimen that I how will help and am having an MRI next week. It was a great experience
The Dr was extremely polite. He was also professional. knowledgeable and kind. So was the Dr working with him.
Very professional, nice office atmosphere, polite
Excellent doctor, I was treated with great care. Dr Brenner is an exceptional physician. Listens well and cares greatly about my health. I am very grateful for his support and advice. Always a pleasant and compassionate person.
Dr. Brenner is the best! He has recommended the treatment of spinal cord stimulation and it has been quite successful. His expert care has been very reassuring and calming.
Hopeful experience thanks
Dr. Brenner was terrific.