Request a Second Opinion with the SIC Team
Receiving an online second opinion can offer reassurance about a challenging diagnosis or help plan the most appropriate course of treatment. The Severe Immunotherapy Complications (SIC) program has a world-class team of specialists , comprising oncologists focusing on immunotherapy complications, alongside experts in neurology, gastrointestinal health, cardiology, hematology, rheumatology, nephrology, dermatology, pulmonary, renal, and ophthalmology. These experts are available to offer remote second opinions to patients and health care providers, eliminating the necessity for travel to Boston.
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Overview
We are in the midst of an exciting revolution in the treatment of cancer. By harnessing and enhancing the body’s immune system using novel therapies such as immune checkpoint inhibitors, we can reduce the amount of tumor burden in patients and, in a subset of patients and cancers, achieve long-lasting remission. However, these therapies are often limited by the unchecked activation of the immune system which can result in immune-related adverse events (irAEs). This toxicity can affect nearly every organ system, ranging from a minor rash to severe dermatological, gastrointestinal, pulmonary, or cardiac complications.
As more patients are treated with immunotherapy, there is a corresponding increase in the number of patients experiencing toxicity which highlights the urgent need to understand how and why immuno-toxicities occur and develop rigorous pathways for how to best manage them.
Researchers take aim at cancer drugs’ toxic side effects Science .
A First-of-its Kind Program
The Severe Immunotherapy Complications (SIC) Service and Clinical-Translational Research Effort, the first-of-its kind across the country, has been at the forefront of developing expertise in the recognition of complex irAE presentations and the management of toxicity. Since October 2017, this multidisciplinary group of clinicians and researchers have been involved in the care of every patient admitted with a suspected irAE after checkpoint blockade immunotherapy.
Each patient presenting to the Mass General Cancer Center with clinical signs or symptoms consistent with an irAE is seen by one of the Cancer Center’s 12 SIC service oncologists, all of whom have expertise in managing severe irAEs. The SIC team can be paged to see admissions 7 days a week, 24 hours a day. The oncologists round daily, review all data related to irAEs, examine and evaluate all patients being treated for irAEs and discuss patient care with the relevant SIC service subspecialists. There are SIC subspecialists from the oncology, allergy/immunology, cardiology, dermatology, endocrinology, hematology, nephrology, neurology, ophthalmology, pulmonology, gastroenterology, infectious disease, and rheumatology divisions.
Kerry Reynolds, MD, Director, Severe Immunotherapy Complications Program
Led by Kerry Reynolds, MD and Chloe-Alexandra Villani, PhD , this multidisciplinary team now comprises more than 50 individuals across 19 areas of the hospital and includes 6 postdoctoral clinical fellows that bridge between clinical and translational efforts, working in both the clinic and the laboratory of Dr. Villani.
Members of the SIC team also advise and educate the larger network community via case discussions and literature review in an educational lecture series every other week. The experts serve as the central referral source for complex cases of irAEs in the city, the state, and beyond. The guiding principle of the clinical SIC service is to develop expertise in recognition and management of irAEs and to extend that expertise to the larger network community and subspecialty arenas.
Our work to date shows that a highly subspecialized care team focused on irAEs can improve clinical outcomes for patients while also creating infrastructure needed to drive future research on irAEs. Importantly, the process of developing expertise in clinical care interfaces directly with development of well-defined clinical phenotypes that can be used to understand the spectrum of these events.
The Mass General Difference
What makes our approach so novel is that we have crossed traditional departmental boundaries at our institution and brought together expertise from each and every relevant clinical division, along with cutting edge scientists, to form a new hybrid community with a common goal. This was possible given that Massachusetts General Hospital is a “general” hospital with previous expertise in autoimmunity across disease states and, importantly, because there exists an undeterrable sense of community and dedication to our patients.
Understanding the Mechanisms Driving irAEs
The SIC service has also joined together to set up an infrastructure for specimen collection, under the leadership of Dr. Alexandra-Chloe Villani, with the hope of understanding the mechanisms driving irAEs. One of our goals is to develop better therapies for treating autoimmune toxicities, while maintaining anti-tumor immunity.
Villani Lab
This group of scientists and clinicians are working towards developing a better understanding of the biological players and underlying molecular and cellular mechanisms involved in driving irAEs by directly studying patient blood and matched affected tissue samples using a range of systems immunology, immunogenomics and single-cell ‘omics’ strategies.
Visit the Villani lab
Research Spotlight: A Better Understanding of Immune Checkpoint Inhibitor-Related Colitis Nature Medicine
Publications
2024
Reardon, R. M., Perlman, K. L., Asdourian, M. S., Shah, N., Jacoby, T. V., Thompson, L. L., Reynolds, K. L., Semenov, Y. R., & Chen, S. T. (2024). Associations between dermatologic immune-related adverse event morphologies and systemic immunomodulatory/immunosuppressive treatment: A large retrospective cohort study . Journal of the American Academy of Dermatology, S0190-9622(24)00309-8. Advance online publication.
Wan, G., Khattab, S., Leung, B. W., Zhang, S., Nguyen, N., Tran, M., Lin, C., Chang, C., Alexander, N., Jairath, R., Phillipps, J., Tang, K., Rajeh, A., Zubiri, L., Chen, S. T., Demehri, S., Yu, K. H., Gusev, A., Kwatra, S. G., LeBoeuf, N. R., … Semenov, Y. R. (2024). Cancer Type and Histology Influence Cutaneous Immunotherapy Toxicities: A Multi-Institutional Cohort Study . The British journal of dermatology, ljae053. Advance online publication.
Chen, S. T., Semenov, Y. R., Alloo, A., Bach, D. Q., Betof Warner, A., Bougrine, A., Burton, L., Cappelli, L. C., Castells, M., Cohen, J., Dewan, A. K., Fadden, R., Guggina, L., Hegde, A., Huang, V., Johnson, D. B., Kaffenberger, B., Kroshinsky, D., Kwatra, S., Kwong, B., … LeBoeuf, N. R. (2024). Defining D-irAEs: consensus-based disease definitions for the diagnosis of dermatologic adverse events from immune checkpoint inhibitor therapy . Journal for immunotherapy of cancer, 12(4), e007675.
Gergely, T. G., Drobni, Z. D., Kallikourdis, M., Zhu, H., Meijers, W. C., Neilan, T. G., Rassaf, T., Ferdinandy, P., & Varga, Z. V. (2024). Immune checkpoints in cardiac physiology and pathology: therapeutic targets for heart failure . Nature reviews. Cardiology, 10.1038/s41569-023-00986-9. Advance online publication.
Ertl, C., Ruf, T., Mentzer, D., Kong, M., Kramer, R., Bergwelt-Baildon, M. V., Subklewe, M., Tomsitz, D., Ascierto, P. A., Dummer, R., Gogas, H., Lebbé, C., Long, G. V., McArthur, G., Neilan, T. G., Ribas, A., Robert, C., Schadendorf, D., Zimmer, L., Eigentler, T., … Heinzerling, L. (2024). The side effect registry immuno-oncology (SERIO) - A tool for systematic analysis of immunotherapy-induced side effects . European journal of cancer (Oxford, England : 1990), 199, 113505.
Dougan, M., Nguyen, L. H., Buchbinder, E. I., & Lazarus, H. M. (2024). Sargramostim for Prophylactic Management of Gastrointestinal Immune-Related Adverse Events of Immune Checkpoint Inhibitor Therapy for Cancer . Cancers, 16(3), 501
Rashdan, H., Zhang, S., Wan, G., Nguyen, N., Roster, K., Rajeh, A., Tang, K., Chen, W., Moseley, C., Chen, S., LeBoeuf, N., & Semenov, Y. R. (2024). Timing of cutaneous immune-related adverse events impacts survival in patients with cancer treated with immune-checkpoint inhibitors: A multi-institutional cohort study . Journal of the American Academy of Dermatology, 90(5), 1080–1083.
Roster, K., Rajeh, A., Nguyen, N., Tang, K., Zhang, S., Rashdan, H., Wan, G., Leung, B. W., Khattab, S., Chen, S., LeBoeuf, N. R., & Semenov, Y. R. (2024). Checkpoint inhibitor antibody type influences the development of cutaneous immune-related adverse events: A multi-institutional study . Journal of the American Academy of Dermatology, 90(1), 189–192.
Reardon, R. M., Perlman, K. L., Asdourian, M. S., Shah, N., Jacoby, T. V., Thompson, L. L., Reynolds, K. L., Semenov, Y. R., & Chen, S. T. (2024). Associations between dermatologic immune-related adverse event morphologies and systemic immunomodulatory/immunosuppressive treatment: A large retrospective cohort study . Journal of the American Academy of Dermatology, S0190-9622(24)00309-8. Advance online publication. https://doi.org/10.1016/j.jaad.2024.01.070
Wan, G., Khattab, S., Leung, B. W., Zhang, S., Nguyen, N., Tran, M., Lin, C., Chang, C., Alexander, N., Jairath, R., Phillipps, J., Tang, K., Rajeh, A., Zubiri, L., Chen, S. T., Demehri, S., Yu, K. H., Gusev, A., Kwatra, S. G., LeBoeuf, N. R., … Semenov, Y. R. (2024). Cancer Type and Histology Influence Cutaneous Immunotherapy Toxicities: A Multi-Institutional Cohort Study . The British journal of dermatology, ljae053. Advance online publication. https://doi.org/10.1093/bjd/ljae053
Chen, S. T., Semenov, Y. R., Alloo, A., Bach, D. Q., Betof Warner, A., Bougrine, A., Burton, L., Cappelli, L. C., Castells, M., Cohen, J., Dewan, A. K., Fadden, R., Guggina, L., Hegde, A., Huang, V., Johnson, D. B., Kaffenberger, B., Kroshinsky, D., Kwatra, S., Kwong, B., … LeBoeuf, N. R. (2024). Defining D-irAEs: consensus-based disease definitions for the diagnosis of dermatologic adverse events from immune checkpoint inhibitor therapy . Journal for immunotherapy of cancer, 12(4), e007675. https://doi.org/10.1136/jitc-2023-007675
Gergely, T. G., Drobni, Z. D., Kallikourdis, M., Zhu, H., Meijers, W. C., Neilan, T. G., Rassaf, T., Ferdinandy, P., & Varga, Z. V. (2024). Immune checkpoints in cardiac physiology and pathology: therapeutic targets for heart failure . Nature reviews. Cardiology, 10.1038/s41569-023-00986-9. Advance online publication. https://doi.org/10.1038/s41569-023-00986-9
Ertl, C., Ruf, T., Mentzer, D., Kong, M., Kramer, R., Bergwelt-Baildon, M. V., Subklewe, M., Tomsitz, D., Ascierto, P. A., Dummer, R., Gogas, H., Lebbé, C., Long, G. V., McArthur, G., Neilan, T. G., Ribas, A., Robert, C., Schadendorf, D., Zimmer, L., Eigentler, T., … Heinzerling, L. (2024). The side effect registry immuno-oncology (SERIO) - A tool for systematic analysis of immunotherapy-induced side effects . European journal of cancer (Oxford, England : 1990), 199, 113505. https://doi.org/10.1016/j.ejca.2023.113505
Dougan, M., Nguyen, L. H., Buchbinder, E. I., & Lazarus, H. M. (2024). Sargramostim for Prophylactic Management of Gastrointestinal Immune-Related Adverse Events of Immune Checkpoint Inhibitor Therapy for Cancer . Cancers, 16(3), 501. https://doi.org/10.3390/cancers16030501
Rashdan, H., Zhang, S., Wan, G., Nguyen, N., Roster, K., Rajeh, A., Tang, K., Chen, W., Moseley, C., Chen, S., LeBoeuf, N., & Semenov, Y. R. (2024). Timing of cutaneous immune-related adverse events impacts survival in patients with cancer treated with immune-checkpoint inhibitors: A multi-institutional cohort study . Journal of the American Academy of Dermatology, 90(5), 1080–1083. https://doi.org/10.1016/j.jaad.2024.01.038
Roster, K., Rajeh, A., Nguyen, N., Tang, K., Zhang, S., Rashdan, H., Wan, G., Leung, B. W., Khattab, S., Chen, S., LeBoeuf, N. R., & Semenov, Y. R. (2024). Checkpoint inhibitor antibody type influences the development of cutaneous immune-related adverse events: A multi-institutional study. Journal of the American Academy of Dermatology, 90(1), 189–192. https://doi.org/10.1016/j.jaad.2023.09.031
Falade AS, Boulanger MC, Hsu K, et al. Learning About and Living With Toxicity: A Qualitative Study of Patients Receiving Immune Checkpoint Inhibitors For Melanoma or Lung Cancer and Their Caregivers . Preprint. Res Sq. 2024;rs.3.rs-4576328. Published 2024 Jul 4. doi:10.21203/rs.3.rs-4576328/v1
Thomas MF, Slowikowski K, Manakongtreecheep K, et al. Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis . Nat Med. 2024;30(5):1349-1362. doi:10.1038/s41591-024-02895-x
Sun VH, Heemelaar JC, Hadzic I, et al. Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease Codes in Patient Records . J Clin Oncol. Published online September 3, 2024. doi:10.1200/JCO.24.00326
Ruiz-Esteves KN, Shank KR, Deutsch AJ, et al. Identification of Immune Checkpoint Inhibitor-Induced Diabetes . JAMA Oncol. Published online August 29, 2024. doi:10.1001/jamaoncol.2024.3104
Gupta S, Green-Lingren O, Bhimaniya S, et al. F18-FDG PET imaging as a diagnostic tool for immune checkpoint inhibitor-associated acute kidney injury. J Clin Invest. Published online August 8, 2024. doi:10.1172/JCI182275
Falade A, Zubiri L, Wu CY, et al. Immune-related adverse events requiring hospitalization in patients with lung cancer: implications and insights . Oncologist. Published online July 26, 2024. doi:10.1093/oncolo/oyae189
Wan G, Chen W, Khattab S, et al. Multi-organ immune-related adverse events from immune checkpoint inhibitors and their downstream implications: a retrospective multicohort study . Lancet Oncol. 2024;25(8):1053-1069. doi:10.1016/S1470-2045(24)00278-X
Mooradian MJ, Fintelmann FJ, LaSalle TJ, et al. Cryoablation and post-progression immune checkpoint inhibition in metastatic melanoma: a phase II trial . Nat Commun. 2024;15(1):7357. Published 2024 Aug 27. doi:10.1038/s41467-024-51722-x
Varma S, Sullivan K, DiCarlo J, Coromilas A, Staller K, Dougan M. The Development of Persistent Gastrointestinal Symptoms in Patients With Melanoma Who Have Had an Immune Checkpoint Inhibitor-Related Gastrointestinal Toxicity . Clin Transl Gastroenterol. 2024;15(8):e00746. Published 2024 Aug 1. doi:10.14309/ctg.0000000000000746
Ma KS, Chiang CH, Chen ST, et al. Periodontitis is an immune-related adverse event associated with immune checkpoint inhibitors: A multi-center cohort study . Cancer Lett. 2024;598:217100. doi:10.1016/j.canlet.2024.217100
2023
Shi CR, Shaughnessy M, Sehgal K, et al. Successful rechallenge with pembrolizumab after case of progressive immunotherapy-related mucocutaneous eruption (PIRME), a Stevens-Johnson syndrome-like reaction [published online ahead of print, 2023 Jan 11]. Int J Dermatol. 2023;10.1111/ijd.16572. doi:10.1111/ijd.16572
Sise ME, Wang Q, Seethapathy H, et al. Soluble and cell-based markers of immune checkpoint inhibitor-associated nephritis . J Immunother Cancer. 2023;11(1):e006222. doi:10.1136/jitc-2022-006222
Asdourian MS, Shah N, Jacoby TV, et al. Evaluating patterns of co-occurrence between cutaneous and noncutaneous immune-related adverse events after immune checkpoint inhibitor therapy . J Am Acad Dermatol. 2023;88(1):246-249. doi:10.1016/j.jaad.2022.05.015
Asdourian MS, Jacoby TV, Shah N, et al. Non-cutaneous immune-related adverse events predict overall and progression-free survival in patients with cutaneous toxicities after immune checkpoint inhibitor therapy [published online ahead of print, 2023 Jan 31]. J Am Acad Dermatol. 2023;S0190-9622(23)00154-8. doi:10.1016/j.jaad.2022.12.049
Stephens MR, Asdourian MS, Jacoby TV, et al. Tumor-infiltrating lymphocytes as a predictive biomarker of cutaneous immune-related adverse events after immune checkpoint blockade in patients with advanced melanoma [published online ahead of print, 2023 Feb 15]. J Am Acad Dermatol. 2023;S0190-9622(23)00193-7. doi:10.1016/j.jaad.2023.01.040
Zhang S, Tang K, Wan G, et al. Cutaneous immune-related adverse events are associated with longer overall survival in advanced cancer patients on immune checkpoint inhibitors: a multi-institutional cohort study [published online ahead of print, 2023 Jan 31]. J Am Acad Dermatol. 2023;S0190-9622(23)00153-6. doi:10.1016/j.jaad.2022.12.048
Nguyen N, Wan G, Ugwu-Dike P, et al. Influence of melanoma type on incidence and downstream implications of cutaneous immune-related adverse events in the setting of immune checkpoint inhibitor therapy [published online ahead of print, 2023 Feb 22]. J Am Acad Dermatol. 2023;S0190-9622(23)00204-9. doi:10.1016/j.jaad.2023.02.014
Tiu BC, Strohbehn IA, Zhao S, et al. Safety of Immune Checkpoint Inhibitors in Patients With Advanced Chronic Kidney Disease: A Retrospective Cohort Study [published online ahead of print, 2023 Feb 23]. Oncologist. 2023;oyad001. doi:10.1093/oncolo/oyad001
Josan K, Neilan TG. Immune checkpoint inhibitors: acute and chronic cardiovascular complications . Nat Rev Cardiol. 2023;20(2):73-74. doi:10.1038/s41569-022-00827-1
Leung BW, Collier MR, Tiu BC, et al. Patterns in utilization of health care services and medications among patients with cutaneous immune-related adverse events: A population-level cohort study [published online ahead of print, 2023 Feb 9]. J Am Acad Dermatol. 2023;S0190-9622(23)00085-3. doi:10.1016/j.jaad.2022.12.042
Park BC, Narayanan S, Gavraldis A, et al. Rare immune-related adverse events in patients with melanoma: incidence, spectrum, and clinical presentations . Oncoimmunology. 2023;12(1):2188719. Published 2023 Mar 8. doi:10.1080/2162402X.2023.2188719
Jacoby TV, Asdourian MS, Shah N, et al. Low-grade cutaneous immune-related adverse events leading to immunotherapy discontinuation . Clin Exp Dermatol. 2023;48(9):1058-1060. doi:10.1093/ced/llad180
Krasnow NA, Chute DF, Falade AS, North CM, Reynolds KL, Dougan ML. Evaluation of appendectomy as a potential risk factor for immune checkpoint inhibitor-associated enterocolitis . Immunotherapy. 2023;15(12):913-920. doi:10.2217/imt-2022-0245
Wan G, Nguyen N, Leung BW, et al. Pre-Existing Inflammatory Disease Predicts Cutaneous Immunotherapy Toxicity Development: A Multi-Institutional Cohort Study. Preprint. medRxiv. 2023;2023.08.28.23294695. Published 2023 Aug 29. doi:10.1101/2023.08.28.23294695
Seethapathy H, Mistry K, Sise ME. Immunological mechanisms underlying clinical phenotypes and noninvasive diagnosis of immune checkpoint inhibitor-induced kidney disease [published online ahead of print, 2023 Jul 21]. Immunol Rev. 2023;10.1111/imr.13243. doi:10.1111/imr.13243
Dougan M. Gastrointestinal mucosal toxicities from immune checkpoint inhibitors: Current understanding and future directions [published online ahead of print, 2023 Jul 16]. Immunol Rev. 2023;10.1111/imr.13239. doi:10.1111/imr.13239
Dougan M. Weighing Antitumor Immunity against Life-threatening Myocarditis from Immune-Checkpoint Inhibitors . Cancer Discov. 2023;13(5):1040-1042. doi:10.1158/2159-8290.CD-23-0199 19.
Wang SJ, Dougan SK, Dougan M. Immune mechanisms of toxicity from checkpoint inhibitors . Trends Cancer. 2023;9(7):543-553. doi:10.1016/j.trecan.2023.04.002
Heemelaar JC, Antoni ML, Neilan TG. Review: Treatment of immune checkpoint inhibitor-associated myocarditis [published online ahead of print, 2023 Aug 1]. J Cardiovasc Pharmacol. 2023;10.1097/FJC.0000000000001456. doi:10.1097/FJC.0000000000001456
Drobni ZD, Gongora C, Taron J, et al. Impact of immune checkpoint inhibitors on atherosclerosis progression in patients with lung cancer . J Immunother Cancer. 2023;11(7):e007307. doi:10.1136/jitc-2023-007307
Mooradian MJ, Sullivan RJ. Immunotherapy in Melanoma: Recent Advancements and Future Directions. Cancers (Basel) . 2023;15(16):4176. Published 2023 Aug 19. doi:10.3390/cancers15164176
Blum SM, Rouhani SJ, Sullivan RJ. Effects of immune-related adverse events (irAEs) and their treatment on antitumor immune responses [published online ahead of print, 2023 Aug 14]. Immunol Rev. 2023;10.1111/imr.13262. doi:10.1111/imr.13262
Kluger HM, Tawbi H, Feltquate D, et al. Society for Immunotherapy of Cancer (SITC) checkpoint inhibitor resistance definitions: efforts to harmonize terminology and accelerate immuno-oncology drug development [published correction appears in J Immunother Cancer. 2023 Sep;11(9):]. J Immunother Cancer. 2023;11(7):e007309. doi:10.1136/jitc-2023-007309
Blum SM, Zlotoff DA, Smith NP, et al. Immune Responses in Checkpoint Myocarditis Across Heart, Blood, and Tumor . Preprint. bioRxiv. 2023;2023.09.15.557794. Published 2023 Sep 18.
Wan G, Nguyen N, Leung BW, et al. Pre-existing inflammatory disease predicts cutaneous immunotherapy toxicity development: A multi-institutional cohort study . J Am Acad Dermatol. Published online October 13, 2023. doi:10.1016/j.jaad.2023.09.082
Wang M, Reynolds K, Montazeri K, Schaefer EA, Sullivan RJ, Dougan M. Tofacitinib is Effective in Treating Refractory Immune Checkpoint Inhibitor Hepatitis . Clin Gastroenterol Hepatol. Published online December 22, 2023. doi:10.1016/j.cgh.2023.12.011
Carmès L, Bort G, Lux F, et al. AGuIX nanoparticle-nanobody bioconjugates to target immune checkpoint receptors . Nanoscale. Published online December 19, 2023. doi:10.1039/d3nr04777f
2022
Theodosakis N, Ugwu-Dike P, Pahalyants V, Reynolds K, Semenov Y. Title: Immune-checkpoint inhibitor therapy is underutilized in the US: A multi-institutional cohort analysis [published online ahead of print, 2021 Dec 30]. Immunol Lett. 2021;S0165-2478(21)00185-1. doi:10.1016/j.imlet.2021.12.005
Goldinger SM, Buder-Bakhaya K, Lo SN, et al. Chemotherapy after immune checkpoint inhibitor failure in metastatic melanoma: a retrospective multicentre analysis [published online ahead of print, 2021 Dec 21]. Eur J Cancer. 2021;162:22-33. doi:10.1016/j.ejca.2021.11.022
Seethapathy H, Herrmann SM, Sise ME. Immune Checkpoint Inhibitors and Kidney Toxicity: Advances in Diagnosis and Management . Kidney Med. 2021;3(6):1074-1081. Published 2021 Oct 8. doi:10.1016/j.xkme.2021.08.008
Chute DF, Zhao S, Strohbehn IA, et al. Incidence and Predictors of CKD and Estimated GFR Decline in Patients Receiving Immune Checkpoint Inhibitors . Am J Kidney Dis. 2022;79(1):134-137. doi:10.1053/j.ajkd.2021.05.012
Tang K, Seo J, Tiu BC, et al. Association of Cutaneous Immune-Related Adverse Events With Increased Survival in Patients Treated With Anti-Programmed Cell Death 1 and Anti-Programmed Cell Death Ligand 1 Therapy [published online ahead of print, 2022 Jan 12]. JAMA Dermatol. 2022;10.1001/jamadermatol.2021.5476. doi:10.1001/jamadermatol.2021.5476
Drobni ZD, Michielin O, Quinaglia T, et al. Renin-angiotensin-aldosterone system inhibitors and survival in patients with hypertension treated with immune checkpoint inhibitors [published online ahead of print, 2022 Jan 19]. Eur J Cancer. 2022;163:108-118. doi:10.1016/j.ejca.2021.12.024
Herrmann J, Lenihan D, Armenian S, et al. Defining cardiovascular toxicities of cancer therapies: an International Cardio-Oncology Society (IC-OS) consensus statement . Eur Heart J. 2022;43(4):280-299. doi:10.1093/eurheartj/ehab674
Walsh MJ, Dougan M. Checkpoint blockade toxicities: Insights into autoimmunity and treatment . Semin Immunol. 2021;52:101473. doi:10.1016/j.smim.2021.101473
Chang MS, Jacoby TV, Otto TS, et al. Evaluating the treatment of cutaneous adverse events and adherence to National Comprehensive Cancer Network guidelines in patients receiving immune checkpoint inhibitors [published online ahead of print, 2022 Mar 5]. Eur J Cancer. 2022;166:21-23. doi:10.1016/j.ejca.2022.01.032
Asdourian MS, Otto TS, Jacoby TV, et al. Association between serum LDH and cutaneous immune-related adverse events among patients on immune checkpoint inhibitors for advanced melanoma [published online ahead of print, 2022 Feb 19]. J Am Acad Dermatol. 2022;S0190-9622(22)00335-8. doi:10.1016/j.jaad.2022.02.024
Tang K, Tiu BC, Wan G, et al. Pre-Existing Autoimmune Disease and Mortality in Patients Treated With Anti-PD-1 and Anti-PD-L1 Therapy [published online ahead of print, 2022 Feb 21]. J Natl Cancer Inst. 2022;djac046. doi:10.1093/jnci/djac046
Vuong JT, Stein-Merlob AF, Nayeri A, Sallam T, Neilan TG, Yang EH. Immune Checkpoint Therapies and Atherosclerosis: Mechanisms and Clinical Implications: JACC State-of-the-Art Review . J Am Coll Cardiol. 2022;79(6):577-593. doi:10.1016/j.jacc.2021.11.048
Wintersperger BJ, Calvillo-Argüelles O, Lheureux S, et al. Immune checkpoint inhibitor-related myocarditis: an illustrative case series of applying the updated Cardiovascular Magnetic Resonance Lake Louise Criteria . Eur Heart J Case Rep. 2022;6(1):ytab478. Published 2022 Jan 21. doi:10.1093/ehjcr/ytab478
Jacoby TV, Otto TS, Asdourian MS, et al. Association of preexisting drug allergies with cutaneous immune related adverse events among patients on immune checkpoint inhibitor therapy [published online ahead of print, 2022 Mar 15]. Br J Dermatol. 2022;10.1111/bjd.21243. doi:10.1111/bjd.21243
Bello E, Dougan M. Elevated circulating memory T cells precede immunotherapy toxicities in melanoma . Trends Cancer. 2022;8(5):347-349. doi:10.1016/j.trecan.2022.02.008
Le TK, Brown I, Goldberg R, et al. Cutaneous Toxicities Associated with Immune Checkpoint Inhibitors: An Observational, Pharmacovigilance Study [published online ahead of print, 2022 May 20]. J Invest Dermatol. 2022;S0022-202X(22)00389-X. doi:10.1016/j.jid.2022.04.020
Falade AS, Reynolds KL, Zubiri L, et al. Case Report: Fulminant Celiac Disease With Combination Immune Checkpoint Therapy . Front Immunol. 2022;13:871452. Published 2022 Apr 14. doi:10.3389/fimmu.2022.871452
Asdourian MS, Shah N, Jacoby TV, Reynolds KL, Chen ST. Association of Bullous Pemphigoid With Immune Checkpoint Inhibitor Therapy in Patients With Cancer: A Systematic Review [published online ahead of print, 2022 May 25]. JAMA Dermatol. 2022;10.1001/jamadermatol.2022.1624. doi:10.1001/jamadermatol.2022.1624
Tiu BC, Zubiri L, Iheke J, et al. Real-world incidence and impact of pneumonitis in patients with lung cancer treated with immune checkpoint inhibitors: a multi-institutional cohort study . J Immunother Cancer. 2022;10(6):e004670. doi:10.1136/jitc-2022-004670
Asdourian MS, Jacoby TV, Shah N, et al. Morphologic characteristics of cutaneous immune-related adverse events in patients receiving immune checkpoint inhibitors combined with other anticancer therapies: A multicenter retrospective study [published online ahead of print , 2022 Jun 17]. J Am Acad Dermatol. 2022;S0190-9622(22)01018-0. doi:10.1016/j.jaad.2022.06.025
Asdourian MS, Shah N, Jacoby TV, et al. Development of multiple cutaneous immune-related adverse events among cancer patients after immune checkpoint blockade [published online ahead of print, 2022 Jun 20]. J Am Acad Dermatol. 2022;S0190-9622(22)01022-2. doi:10.1016/j.jaad.2022.06.030
Rhee JY, Torun N, Neilan TG, Guidon AC. Consider Myocarditis When Patients Treated with Immune Checkpoint Inhibitors Present with Ocular Symptoms . Oncologist. 2022;27(5):e402-e405. doi:10.1093/oncolo/oyac033
Said JT, Talia J, Wei E, et al. Impact of Biologic Therapy on Cancer Outcomes in Patients with Immune Checkpoint Inhibitor-Induced Bullous Pemphigoid [published online ahead of print, 2022 Jun 29]. J Am Acad Dermatol. 2022;S0190-9622(22)02235-6. doi:10.1016/j.jaad.2022.06.1186
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2020
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2019
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Badran YR, Cohen JV, Brastianos PK, Parikh AR, Hong TS, Dougan M. Concurrent therapy with immune checkpoint inhibitors and TNFα blockade in patients with gastrointestinal immune-related adverse events . J Immunother Cancer. Aug 2019;7(1):226. doi:10.1186/s40425-019-0711-0
Chen ST, Molina GE, Lo JA, et al. Dermatology Consultation Reduces Interruption of Oncologic Management Among Hospitalized Patients with Immune-related Adverse Events: A Retrospective Cohort Study . J Am Acad Dermatol. Sep 2019;doi:10.1016/j.jaad.2019.09.026
Criss SD, Mooradian MJ, Watson TR, Gainor JF, Reynolds KL, Kong CY. Cost-effectiveness of Atezolizumab Combination Therapy for First-Line Treatment of Metastatic Nonsquamous Non-Small Cell Lung Cancer in the United States . JAMA Netw Open. Sep 2019;2(9):e1911952. doi:10.1001/jamanetworkopen.2019.11952
Dubey D, David WS, Amato AA, et al. Varied phenotypes and management of immune checkpoint inhibitor-associated neuropathies . Neurology. Sep 2019;93(11):e1093-e1103. doi:10.1212/WNL.0000000000008091
Hughes MS, Zheng H, Zubiri L, et al. Colitis after checkpoint blockade: A retrospective cohort study of melanoma patients requiring admission for symptom control . Cancer Med. Sep 2019;8(11):4986-4999. doi:10.1002/cam4.2397
Rubin KM, Hoffner B, Bullock AC. Caring for Patients Treated With Checkpoint Inhibitors for the Treatment of Metastatic Merkel Cell Carcinoma . Semin Oncol Nurs. Sep 2019:150924. doi:10.1016/j.soncn.2019.08.003
Ganatra S, Parikh R, Neilan TG. Cardiotoxicity of Immune Therapy . Cardiol Clin. Nov 2019;37(4):385-397. doi:10.1016/j.ccl.2019.07.008
Hughes MS, Molina GE, Chen ST, et al. Budesonide treatment for microscopic colitis from immune checkpoint inhibitors . J Immunother Cancer. 11 2019;7(1):292. doi:10.1186/s40425-019-0756-0
Alvi RM, Frigault MJ, Fradley MG, et al. Cardiovascular Events Among Adults Treated With Chimeric Antigen Receptor T-Cells (CAR-T) . J Am Coll Cardiol. 12 2019;74(25):3099-3108. doi:10.1016/j.jacc.2019.10.038
Qualls D, Seethapathy H, Bates H, et al. Positron emission tomography as an adjuvant diagnostic test in the evaluation of checkpoint inhibitor-associated acute interstitial nephritis . J Immunother Cancer. 12 2019;7(1):356. doi:10.1186/s40425-019-0820-9
Seethapathy H, Zhao S, Chute DF, et al. The Incidence, Causes, and Risk Factors of Acute Kidney Injury in Patients Receiving Immune Checkpoint Inhibitors . Clin J Am Soc Nephrol. 12 2019;14(12):1692-1700. doi:10.2215/CJN.00990119
Agor J, Özaltın OY, Ivy JS, Capan M, Arnold R, Romero S. The value of missing information in severity of illness score development . J Biomed Inform. 2019;97:103255. doi:10.1016/j.jbi.2019.103255
Durbin SM, Zubiri L, Niemierko A, et al. Clinical Outcomes of Patients with Metastatic Cancer Receiving Immune Checkpoint Inhibitors in the Inpatient Setting . Oncologist. 2021;26(1):49-55. doi:10.1002/onco.13561
Karschnia P, Jordan JT, Forst DA, et al. Clinical presentation, management, and biomarkers of neurotoxicity after adoptive immunotherapy with CAR T cells . Blood. 2019;133(20):2212-2221. doi:10.1182/blood-2018-12-893396
Thompson JA, Schneider BJ, Brahmer J, et al. Management of Immunotherapy-Related Toxicities, Version 1.2019 . J Natl Compr Canc Netw. 2019;17(3):255-289. doi:10.6004/jnccn.2019.0013
Criss SD, Mooradian MJ, Watson TR, Gainor JF, Reynolds KL, Kong CY. Cost-effectiveness of Atezolizumab Combination Therapy for First-Line Treatment of Metastatic Nonsquamous Non-Small Cell Lung Cancer in the United States . JAMA Netw Open. 2019;2(9):e1911952. Published 2019 Sep 4. doi:10.1001/jamanetworkopen.2019.11952
2018
Mahmood SS, Fradley MG, Cohen JV, et al. Myocarditis in Patients Treated With Immune Checkpoint Inhibitors . J Am Coll Cardiol. 04 2018;71(16):1755-1764. doi:10.1016/j.jacc.2018.02.037
Ostvar S, Choi, J, Chu, J, Nipp, R, Dougan, M, Reynolds, K, Gainor, J, Kong, C, Hur, C. Cost effectiveness of single versus dual immune checkpoint blockade for chemotherapy-refractory esophageal, GE junction, and gastric cancers . American Society of Clinical Oncology Meeting June, 2018.
Reynolds K, Cohen, J, Ryan, D, Hochberg, E, Dougan, M, Thomas, M, Guidon, A, Channick, C, Chen, S, Schoenfeld, S, Sise, M, Leaf, R, Neilan, T, Chu, J, Hur, C, Murciano-Goroff, Y, Villani, A, Nasrallah, M, Sullivan, R, Bardia, A. Severe immune-related adverse effects (irAE) requiring hospital admission in patients treated with immune checkpoint inhibitors for advanced malignancy: temporal trends and clinical significance . American Society of Clinical Oncology Meeting June, 2018.
Ganatra S, Neilan TG. Immune Checkpoint Inhibitor-Associated Myocarditis . Oncologist. Aug 2018;23(8):879-886. doi:10.1634/theoncologist.2018-0130
Mahmood SS, Sullivan RJ, Reynolds KL, Neilan TG. Reply: Immunosuppression Does Not Reduce Antitumor Efficacy . J Am Coll Cardiol. 08 2018;72(6):702. doi:10.1016/j.jacc.2018.06.005
Neilan TG, Rothenberg ML, Amiri-Kordestani L, et al. Myocarditis Associated with Immune Checkpoint Inhibitors: An Expert Consensus on Data Gaps and a Call to Action . Oncologist. 08 2018;23(8):874-878. doi:10.1634/theoncologist.2018-0157
Awadalla M M, S, Reynolds, K, Cohen, J, Sullivan, R, Shah, S, Picard, M, Lawrence, D, et al, Neilan, T. Global Longitudinal Strain and Myocarditis with Immune Checkpoint Inhibitors . Global Cardio-Oncology Summit September 2018.
Faje AT, Lawrence D, Flaherty K, et al. High-dose glucocorticoids for the treatment of ipilimumab-induced hypophysitis is associated with reduced survival in patients with melanoma . Cancer. 09 2018;124(18):3706-3714. doi:10.1002/cncr.31629
Mooradian M, Gainor, J, Dagogo-Jack, I, Reynolds, K. Immune-related adverse events: The Growing Pains of Immunoncology. International Association for the Study of Lung Cancer World Conference September, 2018.
Schoenfeld S, Aronow, M, Karp, R, Dougan, M, Reynolds, K. Rare immune-related Adverse Events (irAEs): Diagnosis and Management. Oncologist 2018.
Reynolds K, Thomas M, Dougan M. Diagnosis and Management of Hepatitis in Patients on Checkpoint Blockade . Oncologist. 09 2018;23(9):991-997. doi:10.1634/theoncologist.2018-0174
Reynolds KL, Guidon AC. Diagnosis and Management of Immune Checkpoint Inhibitor Associated Neurologic Toxicity: Illustrative Case and Review of the Literature . Oncologist. Nov 2018;doi:10.1634/theoncologist.2018-0359
Criss SD, Mooradian MJ, Sheehan DF, et al. Cost-effectiveness and Budgetary Consequence Analysis of Durvalumab Consolidation Therapy vs No Consolidation Therapy After Chemoradiotherapy in Stage III Non-Small Cell Lung Cancer in the Context of the US Health Care System . JAMA Oncol. 2019;5(3):358-365. doi:10.1001/jamaoncol.2018.5449
2017
Mooradian MJ, Sullivan RJ. Immunomodulatory effects of current cancer treatment and the consequences for follow-up immunotherapeutics . Future Oncol. 2017;13(18):1649-1663. doi:10.2217/fon-2017-0117
Thebeau M, Rubin K, Hofmann M, Grimm J, Weinstein A, Choi JN. Management of skin adverse events associated with immune checkpoint inhibitors in patients with melanoma: A nursing perspective . J Am Assoc Nurse Pract. 2017;29(5):294-303. doi:10.1002/2327-6924.12458
Dougan M. Checkpoint Blockade Toxicity and Immune Homeostasis in the Gastrointestinal Tract . Front Immunol. 2017;8:1547. Published 2017 Nov 15. doi:10.3389/fimmu.2017.01547
Wang GX, Kurra V, Gainor JF, et al. Immune Checkpoint Inhibitor Cancer Therapy: Spectrum of Imaging Findings . Radiographics. 2017;37(7):2132-2144. doi:10.1148/rg.2017170085
Dougan M, Dougan SK. Targeting Immunotherapy to the Tumor Microenvironment . J Cell Biochem. 2017;118(10):3049-3054. doi:10.1002/jcb.26005
2015
2014
Team Interviews
In this interview series, Kerry Reynolds, MD, director of the SIC program, sits down with a SIC team member for a deeper-dive into their work.
Facing Immunotherapy: A Guide for Patients and Their Families
Facing Immunotherapy is for anyone whose life is affected by cancer and who is considering (or is receiving) immunotherapy. This book provides easily readable and trustworthy information, which is divided amongst twenty-six chapters that ask and answer pertinent questions about immunotherapy and its medical, surgical, and psychiatric/psychological components. Learn more .
Authored by Mass General physicians, Facing Immunotherapy is for anyone whose life is affected by cancer and who is considering (or is receiving) immunotherapy. This book provides easily readable and trustworthy information, which is divided amongst twenty-six chapters that ask and answer pertinent questions about immunotherapy and its medical, surgical, and psychiatric/psychological components. Learn more.
