About Richard Hodin, MD

Watch a video about my work

Clinical Interests:

Treats:

Locations

Massachusetts General Hospital
55 Fruit St.
Boston, MA 02114
Phone: 617-643-5166

Medical Education

  • MD, Tulane Univ. School of Medicine
  • Residency, Beth Israel Deaconess Hospital
  • Fellowship, Beth Israel Deaconess Hospital
  • Fellowship, Brigham and Women's Hospital

American Board Certifications

  • General Surgery, American Board of Surgery

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Research

The Laboratory of Gastrointestinal Epithelial Biology

Principal Investigator: Richard A. Hodin, MD

The Laboratory of Gastrointestinal Epithelial Biology works to unravel the molecular mechanisms that underlie the processes of growth and differentiation within intestinal epithelia, focusing on gut mucosal defense and how the host interacts with the intestinal microbiota..

The small intestine is lined by a simple columnar epithelium in which pluripotent, proliferating crypt cells (stem cells) give rise to four distinct lineages of differentiated cells, including enterocytes (95%), goblet, and enteroendocrine cells on the villi, and paneth cells at the crypt base. The various projects ongoing in the lab relate to understanding the differentiation process in the contexts of (1) normal development, (2) homeostasis within the adult, (3) pathological conditions such as starvation, cancer, and inflammatory bowel disease. Presently, we are focused on defining the mechanisms that govern gut mucosal defense and the interplay between the host and the intestinal microflora.

Publications