Three-drug combination prolongs survival in men with metastatic, hormone-sensitive prostate cancer
A phase 3 trial demonstrates multiple benefits of adding the androgen-receptor inhibitor darolutamide to standard therapy.
About Matthew Smith, MD, PhD
Dr. Matthew R. Smith is Director of the Genitourinary Oncology Program at Massachusetts General Hospital Cancer Center and an Associate Professor of Medicine at Harvard Medical School. He graduated summa cum laude from Canisius College with a B.A. in biochemistry. He received his MD and PhD degrees from Duke University School of Medicine. He trained in Internal Medicine at Brigham and Women's Hospital. He completed a fellowship in Medical Oncology at Dana Farber Cancer Institute and a postdoctoral fellowship at Massachusetts Institute of Technology.
He is an internationally recognized expert in prostate cancer. He has published extensively on treatment and prevention of bone metastases and prostate cancer survivorship. He has authored more than 150 peer-reviewed articles including manuscripts in New England Journal of Medicine, Journal of Clinical Oncology, Cancer, Journal of Clinical Endocrinology and Metabolism, and Clinical Cancer Research. His research is supported by competitive grants and awards from the National Institutes of Health, Lance Armstrong Foundation Research Award, and the Prostate Cancer Foundation.
Departments, Centers, & Programs:
Clinical Interests:
- Prostate cancer
Treats:
- Adult
Locations
Mass General Cancer Center: Center for Genitourinary Cancers
55 Fruit St.
Boston, MA 02114
Phone: 617-724-4000
Mass General Cancer Center in Waltham
52 Second Ave.
Suite 1110
Waltham, MA 02451
Phone: 781-487-6100
Medical Education
- MD, Duke University School of Medicine
- Residency, Brigham and Women's Hospital
- Fellowship, Dana Farber Cancer Institute
Accepted Insurance Plans
- Aetna
- Beech Street
- Blue Cross Blue Shield
- Blue Cross Blue Shield Medicare
- Cigna
- Commonwealth Care Alliance
- Coventry
- Fallon Health
- Harvard Pilgrim Health Care
- Humana
- Maine Community Health Options
- Mass General Brigham Health Plan
- MassHealth
- Medicaid ME
- Medicaid NH
- Medicaid RI
- Medicare
- Medicare ACO
- Multiplan
- Railroad Medicare
- Senior Whole Health
- TriCare
- Tufts Health Plan
- United Health Care
- Wellpoint
- WellSense
- WellSense NH
Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.
Research
Dr. Smith leads a clinical research program in prostate cancer focused on cancer survivorship, treatment and prevention of bone metastases, and novel therapeutics. With a multidisciplinary research team, he identified previously unrecognized adverse effects of androgen deprivation therapy including osteoporosis, sarcopenia, obesity, lipid alterations, insulin resistance, and greater risks for fractures, diabetes, and cardiovascular disease. These novel observations have provided fundamental insights in the management of prostate cancer and informed the design of global clinical trials to prevent treatment-related morbidity in prostate cancer survivors. His research has contributed to the approval of new drugs to prevent skeletal morbidity in men with prostate cancer. He leads international studies to prevent and treat bone metastases. He leads an active clinical research program in novel therapy for prostate cancer. His research program is supported by principal investigator peer-reviewed research funding from federal, investigator-initiated industry, and foundation grants including an NIH K24 mid-career investigator award and a Prostate Cancer Foundation Transformational grant. He has authored more than 70 original research reports and more than 80 reviews and book chapters on prostate cancer.
Dr. Smith and his team were very thorough, very informative, and explained things in ways that I would understand and left time for follow-up questions. And because of their efforts, I think I'll be able to make a more informed and balanced decision.
The care and all aspects of care were magnificent. They were wonderful. [redacted]
Yeah, I received a diagnosis of prostate cancer. That in itself is a very sort of complicated road to navigate. And I felt that the people at Mass General provided me with a team. It was a team of three doctors, oncologists, radiologists, and a surgeon. And I felt like I was seen more comprehensively at Mass General than I was anywhere else. And ... Read More
Very professional and knowledgeable.
Dr. Smith is a great listener and he makes my experience very pleasant.
Dr. Smith is an outstanding physician who has taken care of me for the past eight years. I can always rely on him for expert care, empathy and support in my struggle with this disease. MGB and it's patients are very fortunate to have such a dedicated physician and researcher on staff.
Excellent experience
Excellent physician
In this time of my life and going through what I'm starting the care has been fantastic. Thanks to all the very warm and wonderful people I have meet.
Excellent care and experience is always given by this provider.