TsengLab
Duchenne Muscular Dystrophy (DMD) is the most common and severe progressive muscular dystrophy to affect children. Dr. Brian Tseng's laboratory investigates the mdx mouse, an animal homolog model of DMD, which lacks the same dystrophin protein but is able to stave off the severity of muscular dystrophy.
Although there are scores of labs working to describe the function(s) of this protein, there has been a paucity of information describing how the downstream effects of dystrophin protein absence can manifest into a severe muscular dystrophy phenotype in humans but not in the mdx mice. The long-term goal will be to elucidate the differential underpinnings in the mdx mouse skeletal muscle (from lab-bench) and exploit such knowledge to translate into better understanding and therapeutics for DMD (at the bedside).
Learn more about Brian Tseng's research.
