INTRODUCTION
Cardiovascular disease is a major cause of morbidity and mortality in the United
States. New treatments are being formulated based on a better understanding of
the signaling pathways involved in the pathogenesis of cardiovascular diseases.
Furthermore, cell replacement therapy has recently emerged as a novel strategy
of correcting contractile and vascular deficiencies in cardiovascular diseases.
The focus of this symposium will be on the use of somatic gene transfer and
cell therapy in cardiovascular diseases. Targeting genes to the heart through
somatic gene transfer or transplanting stem cells have the potential to alter
our approach to patients with cardiovascular diseases. Gene and cell therapy
allow us to test hypotheses about mechanisms of disease, and, it is hoped,
tailor therapy accordingly. In addition, there will be a strong emphasis on
myocardial regeneration by stem cell transplantation and by in situ cardiac
stem cell activation. Clinical trials in both gene and cell therapies will also
be presented. This symposium will bring together scientists from industry,
clinicians and basic scientists. Through this combination of investigators with
multidisciplinary backgrounds, diverse scientific perspectives will be brought
into focus on gene and cell therapy.
The convergence of investigators from different fields which are typically
separate will hopefully foster greater collaborative efforts in gene and cell
therapy and lead to a better understanding of treatment modalities for
cardiovascular diseases.
The Cardiovascular Cell and Gene Therapy Conference III
Cardiovascular Research Center, Massachusetts General Hospital, Bldg. 149 13th Street (149-4201), Charlestown, MA 02129, USA
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